Summary Receptor Potential

Ce membranes


Se ion 2




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, Role of receptors & receptor potential in Intrace ular co unication

Physiological ligand anyphysiological substancethatbinds sensory receptor
orinteractswith a receptor neurotransmitter hormonelocalmediatorantibody

f.info
i mean
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receptors
Generaldefenitionacellproteinmembraneintracellularthata ligandbinds iii
modifiedsensoryneuron apartof modified
sensoryreceptor
sensoryneuron 3anyotherspecializedcellthatconverts a stimulus membraneboundreceptor
intoreceptorpotentialwhich if it reaches surpasses the
thresholdpotential it initiates impulsein associatednerve


cell specialization
cellsmustcommunicate inmannerthat intracellularreceptors
1 similarcellscanperform acertainfunction
aclassofcellscancommunicate toanotherclasswhentheirneedschange
matron in
sensoryreceptor clinical importance cellmembrane
individualadaptation homeostaticresponse
somatic vs autonomicreflexfunction
3 neurologicalphysicalexamination
byDoctor
note eachsensoryreceptorismostsensative to a specifictype of
stimulation which it convertsintosensoryinformation
actionPotentiale threshold receptorPotential Receptors
C
É
Taing afferentneuro
signaltransduction process of converting a of
neural sensory ligandmediatedmessage stimulus g separatereceptorcell
associatedwith
into a actionpotentialin
peripheralendingof
ng panway
ii a in p c for to initiate biochemicalresponse




structure i a transmembranedomain no a proteinneeded
effectorsystemis intrinsic partof receptor s cytokinereceptors e g Growthhormones prolactin cytokin
mechanism ofaction aligandbind autophosphorination a cause aligandbindstoreceptor athatinducesreceptor tobindto Ic
otherproteinstobephosphoritized3phosphorinationcascadestarts kinasesthatcatalyzesphosphorylation
i Isa 3,4
causes e causes Types of IC receptors
i causes

nuclearreceptors bindtothyroidhormones gene
no 3 Gproteincoupledprotein a subunitactivated a initiates a message transcription hormonereceptor
c omplex bindto HREmmolto
to betransducedviaenzymes e.gadenylatecyclase phospholipase c 2 cytoplasmicreceptors steroidhormones bindto cytoplasmic
3whenmembraneproteinactivated inducereleaseof andmessenger receptors normonreceptorc omplexfreed
frominnistorproteinkeeping
orotherintracellularevents viaatpbindingprotein itincytoplasmmoves tonucleus bindsto re initiate
transcription

Factorsdeterming cell response
receptors Ic location receptormodifications egsteroidreceptors ligandreceptorreactionrate ligandreceptorequilibrium
nowquicklyligand ligandbinds dissociate
ligand influencereceptor
affinity affinityreceptorsneeda
low because and fromreceptor
dissociate samerate
rate d issociateis
ligand onlyquickactionstriggers eg neurotransmision receptorfieldstimulusmaybe receptoraffinity
viseversa highaffinity egsecondmessengercascades inoverlappingreceptorfields
ll mm