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Summary

Summary Gastrointestinal tract drugs summarised in a table

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2 pages
2014/2015 Written for academic year
Institution University Of Pretoria (UP)
Course Pharmacology (FAR382)
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I will soon have my Masters in Genetics and I completed my honours in Clinical Pharmacology. The pharmacology was course work on it's own, so the summaries are very well written and easy to learn. If you have Pharmacology, you will know that it is a lot of work to get in your mind in a short amount of time. I want to help you get through all the drug classes.

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Ionisation
IONISED
 POLAR
 Water-soluble
 Lipophobic
 Hydrophilic
 Do not cross membranes readily

 ACIDIC drugs bind to ALBUMIN
 ACIDS are ionised in BASIC media

 BASIC drugs bind to α1-GLYCOPROTEIN
 BASES are ionised in acidic media

UNIONISED
 NON-polar
 Fat soluble
 Hydrophobic
 Lipophilic
 Diffuse more readily across a membrane
 Very HIGH L-WDC
 Distributes widely through the body
 Acts in the CNS (crosses the bbb by PASSIVE DIFFUSION)

Weak ACIDS
HA  A- + H+
¿ IONISED
 pH= pKa + log10 A− HA ¿ Ratio = UNIONISED
With a dissociation constant K
a



Weak BASES
BH+  B + H+
Connected book
image
Humphrey Rang, James M. Ritter Rang & Dale\'s Pharmacology
Publisher: januari 2015 ISBN: 9780702053627 Edition: 1

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2014/2015
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