NR605 ADVANCED
PSYCHOPHARMACOLOGY EXAM 3
QUESTIONS AND ANSWERS 2026/2027
UPDATE || 100% GUARANTEED PASS
1. Which of the following antidepressants is most likely to cause hypertensive crisis if taken
with foods high in tyramine?
A. Sertraline
B. Venlafaxine
C. Fluoxetine
D. Phenelzine
Answer: D
Conceptual Explanation: Phenelzine is a non-selective MAOI that inhibits the breakdown
of tyramine, leading to excessive norepinephrine release and potential hypertensive crisis.
2. A patient taking Clozapine must have their Absolute Neutrophil Count (ANC) monitored
regularly due to the risk of:
A. Agranulocytosis
B. Metabolic Syndrome
C. Neuroleptic Malignant Syndrome
,D. Tardive Dyskinesia
Answer: A
Conceptual Explanation: Clozapine carries a black box warning for agranulocytosis,
necessitating strict ANC monitoring per the REMS program.
3. Which mood stabilizer is associated with a risk of Stevens-Johnson Syndrome, particularly
in patients of Asian descent with the HLA-B*1502 allele?
A. Lithium
B. Valproate
C. Carbamazepine
D. Gabapentin
Answer: C
Conceptual Explanation: Carbamazepine is strongly linked to SJS/TEN in patients with
the HLA-B*1502 allele, and genetic testing is recommended for high-risk populations.
4. What is the primary mechanism of action of Donepezil in the treatment of Alzheimer’s
disease?
A. NMDA receptor antagonism
B. Reversible acetylcholinesterase inhibition
C. D2 receptor antagonism
D. GABA-A receptor modulation
, Answer: B
Conceptual Explanation: Donepezil increases acetylcholine levels in the synaptic cleft by
inhibiting the enzyme acetylcholinesterase.
5. Which of the following is a classic symptom of Lithium toxicity?
A. Bradycardia
B. Weight gain
C. Hypotension
D. Coarse hand tremors
Answer: D
Conceptual Explanation: While fine tremors are a common side effect, coarse hand
tremors, ataxia, and confusion are signs of lithium toxicity.
6. Bupropion is contraindicated in patients with a history of:
A. Major Depression
B. Obesity
C. Smoking
D. Anorexia or Bulimia
Answer: D
PSYCHOPHARMACOLOGY EXAM 3
QUESTIONS AND ANSWERS 2026/2027
UPDATE || 100% GUARANTEED PASS
1. Which of the following antidepressants is most likely to cause hypertensive crisis if taken
with foods high in tyramine?
A. Sertraline
B. Venlafaxine
C. Fluoxetine
D. Phenelzine
Answer: D
Conceptual Explanation: Phenelzine is a non-selective MAOI that inhibits the breakdown
of tyramine, leading to excessive norepinephrine release and potential hypertensive crisis.
2. A patient taking Clozapine must have their Absolute Neutrophil Count (ANC) monitored
regularly due to the risk of:
A. Agranulocytosis
B. Metabolic Syndrome
C. Neuroleptic Malignant Syndrome
,D. Tardive Dyskinesia
Answer: A
Conceptual Explanation: Clozapine carries a black box warning for agranulocytosis,
necessitating strict ANC monitoring per the REMS program.
3. Which mood stabilizer is associated with a risk of Stevens-Johnson Syndrome, particularly
in patients of Asian descent with the HLA-B*1502 allele?
A. Lithium
B. Valproate
C. Carbamazepine
D. Gabapentin
Answer: C
Conceptual Explanation: Carbamazepine is strongly linked to SJS/TEN in patients with
the HLA-B*1502 allele, and genetic testing is recommended for high-risk populations.
4. What is the primary mechanism of action of Donepezil in the treatment of Alzheimer’s
disease?
A. NMDA receptor antagonism
B. Reversible acetylcholinesterase inhibition
C. D2 receptor antagonism
D. GABA-A receptor modulation
, Answer: B
Conceptual Explanation: Donepezil increases acetylcholine levels in the synaptic cleft by
inhibiting the enzyme acetylcholinesterase.
5. Which of the following is a classic symptom of Lithium toxicity?
A. Bradycardia
B. Weight gain
C. Hypotension
D. Coarse hand tremors
Answer: D
Conceptual Explanation: While fine tremors are a common side effect, coarse hand
tremors, ataxia, and confusion are signs of lithium toxicity.
6. Bupropion is contraindicated in patients with a history of:
A. Major Depression
B. Obesity
C. Smoking
D. Anorexia or Bulimia
Answer: D
