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HESI Dosage Calculations Practice Test 2026–2027 – Medication Math Questions, Nursing Calculation Study Guide & Exam Review

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Prepare for the HESI Dosage Calculations Practice Test with a focused nursing math study resource covering dosage formulas, unit conversions, medication calculations, IV flow rates, and safe medication administration calculations. This HESI Dosage Calculation study guide and exam review is designed to support structured practice, reinforce calculation skills, and help nursing students prepare for HESI-style dosage assessments.

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HESI Dosage Calculations Practice Test
A male client receives a prescription for ondansetron hydrochloride (Zofran) 4 mg IV to prevent
postoperative nausea after an inguinal hernia repair. The medication is available in 2 mg/ml.
How many ml should the nurse administer? (Enter numeric value only.)

Use ratio and proportion, 4 mg : X ml = 2 mg : 1 ml 2X = 4 X = 2
Use ratio and proportion, 4 mg : X ml = 2 mg : 1 ml 2X = 4 X = 2




The nurse is preparing to administer Hepatitis B Vaccine, Recombinant (Energix-B) 5 mcg IM to
a school-aged child. The vaccine is labeled, 10 mcg/ml. How many ml should the nurse
administer? (Enter numeric value only. If rounding is required, round to the nearest tenth).
Use ratio and proportion, 5 mcg : X ml :: 10 mcg : 1ml 10X = 5 X = 0.5 ml




At the end of the shift, the nurse is recording the fluid balance for a client receiving a
continuous gastrostomy tube (GT) feeding. Based on the client's records, how many ml should
the nurse record for the total fluid balance (intake - output) for the shift that started at 0700
and ended at 1900? (Enter numeric value only.) (Click on each image asset for additional
information.)
695
The tube feeding is administered at 75 ml/hour for 11 hours (0700 - 1800) and then turned off
for one hour because the residual is greater than 200 ml. 11 hours x 75 ml/hr = 825 ml. Three
doses of 20 ml of medication are administered, with 10 ml of water used to flush the GT before
and after each dose. 20 ml x 3 doses = 60 ml; 10 ml (flush) x 2 x 3 doses = 60 ml; so 825 ml + 60
ml + 60 ml = 945 ml. 250 ml of residual is removed and not replaced. 945 ml - 250 ml = 695 ml
total fluid balance (Intake - output).
A 180-pound adult male is admitted to the Emergency Center after receiving thermal burns to
60 percent of his body. Using the Parkland formula of 4 ml/kg/24 hours, the client should




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receive how many ml of fluid during the first 24 hours? (Enter the numeric value only. If
rounding is required, round to the nearest whole number.)
19632
Using the Parkland formula, the client's fluid requirements for the first 24 hours after injury: 4
ml lactated Ringer's solution x Body weight (in kilograms) x Percent burn. Convert 180 pounds
to kg = .2 = 81.8 kg 4 ml x 81.8 kg x 60 = 19632 ml over the first 24 hours.
The healthcare provider prescribes acetazolamide (Diamox) 600 mg/m2/day divided into 3
doses. The nurse calculates the child's body surface area (BSA) as 0.7 m2. How many mg should
the child receive per dose? (Enter the numeric value only.)
Using the child's BSA, 0.7 m2, calculate the mg/dose, 600 mg x 0.7 m2 = 420 mg/day/3 doses =
140 mg/dose
A loading dose of acetylcysteine (Mucomyst) 8 grams, which is available as a 20% solution (200
mg acetylcysteine per ml) is prescribed by nasogastric tube for a client with acetaminophen
toxicity. How many ml of diluent should be added to the medication to obtain a 1:4
concentration? (Enter the numerical value only. If rounding is required, round to the whole
number.)
8 grams = 8,000 mg prescribed dose. Using the formula, D/H x Q, 8,000 mg / 200 mg x 1 ml = 40
ml of the 20% solution. Dilute the 40 ml to a 1:4 concentration for administration using ratio
and proportion, 1 : 4 solution :: 40 ml : X X= 160 ml total volume to administer. Subtract total
volume of 160 ml - 40 ml of 20% concentration = 120 ml diluent is added to obtain a 1:4
concentration.
A child who weighs 55 pounds receives a prescription for atovaquone with proguanil (Malarone
Pediatric) 125 mg/50 mg PO daily. A drug reference states that children 11 to 20 kg should
receive 1 pediatric tablet daily; 21 to 30 kg should receive 2 pediatric tablets daily; 31 to 40 kg
should receive 3 pediatric tablets daily; and greater than 40 kg should receive 1 adult tablet
daily with food. The drug is available as atovaquone 62.5 mg/proguanil 25 mg pediatric tablets.
How many tablets should the nurse administer?
Calculate each drug component dose, using the formula, D/H 125 mg / 62.5 mg (atovaquone) =
2 combined with 50 mg / 25 mg (proguanil) = 2. The child should receive 2 tablets.
A child who is scheduled for a kidney transplant receives a prescription for basiliximab
(Simulect) 20 mg IV 2 hours prior to surgery. The medication is available in a 20 mg vial that is
reconstituted by adding 5 ml sterile water for injection, and administered in a 50 ml bag of
normal saline over 30 minutes. The nurse should program the infusion pump to deliver how
many ml/hour? (Enter the numeric value only.)




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