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HESI Pathophysiology Practice Exam 2026–2027 – Comprehensive Study Guide, Exam Review, Practice Questions & Nursing Preparation

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Prepare for the HESI Pathophysiology Practice Exam with a comprehensive review resource covering essential disease processes, physiological changes, signs and symptoms, risk factors, complications, and core nursing concepts. This HESI Pathophysiology exam study guide is designed to support nursing students through focused practice questions, concept review, and structured preparation for HESI-style assessments and pathophysiology coursework.

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HESI PATHOPHYSIOLOGY PRACTICE
EXAM


As the prostate gland enlarges, its cells contribute more PSA in the circulating blood



PSA is a glycoprotein found in prostatic epithelial cells, and elevations are used as a specific tumor
markers. Elevations in PSA are r/t gland volume, ie. benign BPH, prostatitis, and cancer of the prostate,
indicating tumor cell load. PSA levels are also used to monitor response to therapy

After talking w/ the HCP, a male pt continues to have questions about the results of a prostatic surface
antigen (PSA) screening test and asks the nurse how the PSA levels become elevated. The nurse should
explain which pathophysiological mechanism?




Permanent sterility occurs in the male client who receive radiation



Low sperm count and loss of motility are seen in males w/ Hodgkin's disease b/f any therapy.
Radiotherapy often results in permanent aspermia, or sterility

A 26 yr old male client w/ Hodgkin's disease is scheduled to undergo radiation therapy. The clinet
expresses concern about the effect of radiation on his ability to have children. What info should the
nurse provide?




Crackles in the right and left lower lobes



Fine crackles - short, high-pitched sounds heard just b/f the end of inspiration that are the result of rapid
equalization of pressure when collaped alveoli or terminal bronchioles suddenly snap open




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Wheezing is a continuous high-pitched squeaking or musical sound caused by rapid vibration of
bronchial walls that are 1st evident on expiration and may be audible

The nurse hears short, high-pitched sounds just b/f the end of inspiration in the right and left lower
lobes when auscultating a client's lungs. How should this finding be recorded?




A deviation of the trachea toward the side opposite of the pneumothorax



Tension pneumothorax is caused by rapid accumulation of air in the pleural space, causing severely high
intrapleural pressure. This results in collapse of the lung, and the mediastinum shifts toward the
unaffected side, which is subsequently compressed

A client is admitted to the ER w/ a tension pneumothorax. Which assessment should the nurse expect to
ID?




A febrile transfusion reaction



Sx of a febrile reaction include sudden chills, fever, HA, flushing, and muscle pain.



An allergic rxn is the response of histamine release which is characterized by flushing, itching, and
urticaria. It exhibits an exaggerated allergic response that progresses to shock and possible cardiac
arrest



an acute hemolytic reaction presents w/ fever, chills, but is hallmarked by the onset of low back pain,
tachycardia, tachypnea, vascular collapse, hemoglobinuria, dark urine, ARF, shock, cardiac arrest, and
even death

A client who is receiving a whole blood transfusion dv's chills, fever, and a HA 30 min after the
transfusion is started. The nurse shold recognize these sx as characteristic of what rxn?




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Uploaded on
September 30, 2026
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