NSG 552 Psychopharmacology Exam
1 – Wilkes University | 2026/2027
Complete Q&A with Rationales |
Grade A+ Guaranteed Pass
,Domain 1: Pharmacokinetics and Pharmacodynamics
1. Which term describes what the body does to a drug?
A. Pharmacodynamics
B. Pharmacokinetics
C. Pharmacogenomics
D. Pharmacotherapeutics
B. Pharmacokinetics
Rationale: Pharmacokinetics involves absorption, distribution, metabolism,
and excretion.
2. Which term describes what a drug does to the body?
A. Pharmacokinetics
B. Pharmacodynamics
C. Pharmacognosy
D. Pharmacoeconomics
B. Pharmacodynamics
Rationale: Pharmacodynamics explains drug-receptor interactions and
physiologic effects.
3. What is the movement of a drug from its administration site into the
bloodstream called?
A. Distribution
B. Metabolism
C. Absorption
D. Excretion
C. Absorption
, Rationale: Absorption determines how quickly and how much drug enters
systemic circulation.
4. What is the fraction of an administered drug that reaches systemic
circulation unchanged?
A. Half-life
B. Bioavailability
C. Clearance
D. Volume of distribution
B. Bioavailability
Rationale: Bioavailability reflects the amount of active drug available to
produce effects.
5. First-pass metabolism primarily occurs in which organ?
A. Kidney
B. Lung
C. Liver
D. Spleen
C. Liver
Rationale: Orally administered drugs are often metabolized by the liver
before reaching systemic circulation.
6. What does a drug half-life measure?
A. Time to reach peak effect
B. Time to eliminate 50% of the drug from plasma
C. Time to develop tolerance
D. Time to reach steady state
, B. Time to eliminate 50% of the drug from plasma
Rationale: Half-life helps estimate dosing intervals and time to steady state.
7. What effect does a cytochrome P450 enzyme inhibitor have on a substrate
drug?
A. Decreases its serum level
B. Increases its serum level
C. Has no effect
D. Increases renal excretion
B. Increases its serum level
Rationale: Enzyme inhibitors slow metabolism, raising substrate drug
concentrations and toxicity risk.
8. What effect does a cytochrome P450 enzyme inducer have on a substrate
drug?
A. Increases its serum level
B. Decreases its serum level
C. Prevents absorption
D. Blocks renal excretion
B. Decreases its serum level
Rationale: Enzyme inducers speed metabolism, reducing substrate drug
levels and therapeutic effect.
9. Which CYP450 enzyme metabolizes approximately 25% of psychiatric
medications?
A. CYP1A2
B. CYP2D6
1 – Wilkes University | 2026/2027
Complete Q&A with Rationales |
Grade A+ Guaranteed Pass
,Domain 1: Pharmacokinetics and Pharmacodynamics
1. Which term describes what the body does to a drug?
A. Pharmacodynamics
B. Pharmacokinetics
C. Pharmacogenomics
D. Pharmacotherapeutics
B. Pharmacokinetics
Rationale: Pharmacokinetics involves absorption, distribution, metabolism,
and excretion.
2. Which term describes what a drug does to the body?
A. Pharmacokinetics
B. Pharmacodynamics
C. Pharmacognosy
D. Pharmacoeconomics
B. Pharmacodynamics
Rationale: Pharmacodynamics explains drug-receptor interactions and
physiologic effects.
3. What is the movement of a drug from its administration site into the
bloodstream called?
A. Distribution
B. Metabolism
C. Absorption
D. Excretion
C. Absorption
, Rationale: Absorption determines how quickly and how much drug enters
systemic circulation.
4. What is the fraction of an administered drug that reaches systemic
circulation unchanged?
A. Half-life
B. Bioavailability
C. Clearance
D. Volume of distribution
B. Bioavailability
Rationale: Bioavailability reflects the amount of active drug available to
produce effects.
5. First-pass metabolism primarily occurs in which organ?
A. Kidney
B. Lung
C. Liver
D. Spleen
C. Liver
Rationale: Orally administered drugs are often metabolized by the liver
before reaching systemic circulation.
6. What does a drug half-life measure?
A. Time to reach peak effect
B. Time to eliminate 50% of the drug from plasma
C. Time to develop tolerance
D. Time to reach steady state
, B. Time to eliminate 50% of the drug from plasma
Rationale: Half-life helps estimate dosing intervals and time to steady state.
7. What effect does a cytochrome P450 enzyme inhibitor have on a substrate
drug?
A. Decreases its serum level
B. Increases its serum level
C. Has no effect
D. Increases renal excretion
B. Increases its serum level
Rationale: Enzyme inhibitors slow metabolism, raising substrate drug
concentrations and toxicity risk.
8. What effect does a cytochrome P450 enzyme inducer have on a substrate
drug?
A. Increases its serum level
B. Decreases its serum level
C. Prevents absorption
D. Blocks renal excretion
B. Decreases its serum level
Rationale: Enzyme inducers speed metabolism, reducing substrate drug
levels and therapeutic effect.
9. Which CYP450 enzyme metabolizes approximately 25% of psychiatric
medications?
A. CYP1A2
B. CYP2D6
