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HESI Pharmacology Practice Exam – Questions, Answers & Study Guide

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Prepare for the HESI Pharmacology Practice Exam with a comprehensive study resource designed to help nursing students review essential pharmacology concepts and practice exam-style questions. This HESI Pharmacology practice resource includes questions and answers covering medication knowledge, pharmacologic principles, safe medication administration, and nursing responsibilities related to patient care. Review important topics such as medication classifications, mechanisms of action, therapeutic effects, adverse reactions, common side effects, contraindications, drug interactions, precautions, dosage considerations, routes of administration, medication monitoring, nursing interventions, and patient education. The practice questions can help reinforce understanding of commonly studied medications and the clinical considerations nurses should recognize when administering and evaluating medications. The HESI Pharmacology Practice Exam can be used as a supplementary study guide alongside nursing textbooks, course materials, instructor guidance, drug references, and approved HESI preparation resources. Reviewing answers and rationales can help students identify knowledge gaps, strengthen clinical reasoning, and better understand the relationship between medications, patient conditions, and nursing interventions. Whether you are preparing for a pharmacology course exam, HESI assessment, or comprehensive nursing review, this practice resource provides structured opportunities to test your knowledge and reinforce key concepts. Use the HESI Pharmacology practice questions and answers to support consistent review, improve familiarity with exam-style questions, and build confidence with medication-related nursing concepts.

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HESI Pharmacology Practice Exam




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A client is receiving metoprolol (Lopressor SR). What assessment is most important for
the nurse to obtain?
A) Temperature.
B) Lung sounds.
C) Blood pressure.
D) Urinary output.


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C.
It is most important to monitor the blood pressure (C) of clients taking this
medication because Lopressor is an antianginal, antiarrhythmic,
antihypertensive agent. While (A and B) are important data to obtain on any
client, they are not as important for a client receiving Lopressor as (C).
Intake and output ratios and daily weights should be monitored while
taking Lopressor to assess for signs and symptoms of congestive heart
failure, but (D) alone does not have the importance of (C).




A client with Parkinson's disease is taking carbidopa-levodopa (Sinemet). Which
observation by the nurse should indicate that the desired outcome of the medication
is being achieved?
A) Decreased blood pressure.
B) Lessening of tremors.
C) Increased salivation.
D) Increased attention span.


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B.
Sinemet increases the amount of levodopa to the CNS (dopamine to the
brain). Increased amounts of dopamine improve the symptoms of
Parkinson's, such as involuntary movements, resting tremors (B), shuffling
gait, etc. (A) is a side effect of Sinemet. Decreased drooling would be a
desired effect, not (C). Sinemet does not affect (D).




The nitrate isosorbide dinitrate (Isordil) is prescribed for a client with angina. Which
instruction should the nurse include in this client's discharge teaching plan?
A) Quit taking the medication if dizziness occurs.
B) Do not get up quickly. Always rise slowly.
C) Take the medication with food only.
D) Increase your intake of potassium-rich foods.


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B.
An expected side effect of nitrates is orthostatic hypotension and the nurse
should address how to prevent it--by rising slowly (B). Dizziness is
expected, and the client should not quit taking the medication without
notifying the healthcare provider (A). (C and D) are not indicated when
taking this medication.




The healthcare provider prescribes naloxone (Narcan) for a client in the emergency
room. Which assessment data would indicate that the naloxone has been effective?
The client's
A) statement that the chest pain is better.
B) respiratory rate is 16 breaths/minute.
C) seizure activity has stopped temporarily.
D) pupils are constricted bilaterally.


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B.
Naloxone (Narcan) is a narcotic antagonist that reverses the respiratory
depression effects of opiate overdose, so assessment of a normal
respiratory rate (B) would indicate that the respiratory depression has been
halted. (A, C, and D) are not related to naloxone (Narcan) administration.




A postoperative client has been recieving a continuous IV infusion of meperidine
(demerol) 35mg/hr for four days. The client has a PRN prescription for Demorol
100mg PO Q3H. The nurse notes that the client has become increasingly restless,
irritable and confused, stating that there are bugs all over the walls. What action
should the nurse take FIRST?
A. Administer a PRN dose of the PO meperidine (demorol)
B. Administer naloxone (narcan) IV per PRN protocol
C. Decrease the IV infusion rate of the demerol per protocol
D. notify the healthcare provider of the clients confusion and hallucinations



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