NR 507 Advanced Patho Midterm Study Guide Questions with
Verified Answers (Correct Update)
Question 1: Infectivity
Answer: The ability of a pathogen to invade and multiply in the host.
Question 2: Anemia
Answer: Most common blood disorder in children
Question 3: Hemolytic Anemia's of Newborns
Answer: Are Inherited, Congenital, or Both
Question 4: Hemolytic Disease of the Newborn (HDN)
Answer: Also called Erythroblastosis fetalis
Question 5: HDN
Answer: Alloimmune disorder in which maternal blood and fetal blood are antigenically incompatible
causing the mother's immune system to produce antibodies against fetal erythrocytes.
Question 6: Iron Deficiency Anemia
Answer: most common blood disorder of infancy and childhood with highest incidence between 6
months and 2 years old
Question 7: Inactive MLH1 and Inherited Colon Cancer
Answer: A major cause of one form of inherited colon cancer (hereditary nonpolyposis colorectal cancer
[HNPCC]) is the methylation of the promoter region of a gene, MLH1, whose protein product repairs
damaged DNA. When MLH1 becomes inactive, damaged DNA accumulates, eventually resulting in
colon tumors.
Question 8: Conditions where inflammation is etiology of Cancer
Answer: INFLAMMATORY CONDITION ASSOCIATED NEOPLASM(S) Asbestosis,
silicosis-Mesothelioma, lung carcinoma Bronchitis-Lung carcinoma Cystitis, bladder
inflammation-Bladder carcinoma Gingivitis, lichen planus-Oral squamous cell carcinoma Inflammatory
bowel disease, Crohn disease, chronic ulcerative colitis-Colorectal carcinoma Lichen sclerosus-Vulvar
squamous cell carcinoma Chronic pancreatitis, hereditary pancreatitis- Pancreatic carcinoma Reflux
esophagitis, Barrett esophagus-Esophageal carcinoma Sialadenitis-Salivary gland carcinoma Sjögren
syndrome, Hashimoto thyroiditis-MALT lymphoma Skin inflammation-Melanoma
Page 1
, Question 9: Chronic inflammation predisposes one to ______________.
Answer: Cancer
Question 10: Organs susceptible to Oncogenic effects of chronic inflammation
Answer: the gastrointestinal (GI) tract, prostate, thyroid gland, pancreas, urinary bladder, pleura, and
skin.
Question 11: Factors that contribute to development of cancer
Answer: •Lifestyle choices, such as nutritional intake, smoking, or alcohol use
•Environmental conditions, including exposure to sunlight, natural and medical radiation, workplace
exposures, and involuntary or unknown exposures
•Lack of physical exercise and overweight/obesity
•Sexual practices
•Prescribed and illicit medications
•Socioeconomic factors that affect exposures and susceptibility
•Carcinogenic substances present in air, water, and soil
Question 12: What is leading cause of cancer?
Answer: Cigarette smoking
Question 13: Most Effective HIV Treatment
Answer: Anti-retroviral therapy - a combination of drugs Combination of therapy includes at least 3
drugs, #2 NRTI's (nucleoside reverse transciptase inhibitors) and #1 drug from another class.
Question 14: Defected cells of HIV
Answer: The primary surface receptor on HIV is the envelope glycoprotein gp120, which binds to the
CD4 molecule found mostly on the surface of Thelper cells. The major immunologic finding in AIDS is
the striking decrease in the number of CD4 Th cells
Question 15: Prader-Willi Syndrome
Answer: a rare genetic disorder caused by gene deletions on paternal chromosome 15 that result in short
stature, hypotonia, small hands and feet, obesity, mild to moderate mental retardation, and
hypogonadism.
Question 16: Angelman Syndrome (happy puppet syndrome)
Answer: an inherited syndrome of jerky puppetlike movements, frequent laughter, mental and motor
retardation, peculiar open-mouthed facies, and seizures.
Page 2
Verified Answers (Correct Update)
Question 1: Infectivity
Answer: The ability of a pathogen to invade and multiply in the host.
Question 2: Anemia
Answer: Most common blood disorder in children
Question 3: Hemolytic Anemia's of Newborns
Answer: Are Inherited, Congenital, or Both
Question 4: Hemolytic Disease of the Newborn (HDN)
Answer: Also called Erythroblastosis fetalis
Question 5: HDN
Answer: Alloimmune disorder in which maternal blood and fetal blood are antigenically incompatible
causing the mother's immune system to produce antibodies against fetal erythrocytes.
Question 6: Iron Deficiency Anemia
Answer: most common blood disorder of infancy and childhood with highest incidence between 6
months and 2 years old
Question 7: Inactive MLH1 and Inherited Colon Cancer
Answer: A major cause of one form of inherited colon cancer (hereditary nonpolyposis colorectal cancer
[HNPCC]) is the methylation of the promoter region of a gene, MLH1, whose protein product repairs
damaged DNA. When MLH1 becomes inactive, damaged DNA accumulates, eventually resulting in
colon tumors.
Question 8: Conditions where inflammation is etiology of Cancer
Answer: INFLAMMATORY CONDITION ASSOCIATED NEOPLASM(S) Asbestosis,
silicosis-Mesothelioma, lung carcinoma Bronchitis-Lung carcinoma Cystitis, bladder
inflammation-Bladder carcinoma Gingivitis, lichen planus-Oral squamous cell carcinoma Inflammatory
bowel disease, Crohn disease, chronic ulcerative colitis-Colorectal carcinoma Lichen sclerosus-Vulvar
squamous cell carcinoma Chronic pancreatitis, hereditary pancreatitis- Pancreatic carcinoma Reflux
esophagitis, Barrett esophagus-Esophageal carcinoma Sialadenitis-Salivary gland carcinoma Sjögren
syndrome, Hashimoto thyroiditis-MALT lymphoma Skin inflammation-Melanoma
Page 1
, Question 9: Chronic inflammation predisposes one to ______________.
Answer: Cancer
Question 10: Organs susceptible to Oncogenic effects of chronic inflammation
Answer: the gastrointestinal (GI) tract, prostate, thyroid gland, pancreas, urinary bladder, pleura, and
skin.
Question 11: Factors that contribute to development of cancer
Answer: •Lifestyle choices, such as nutritional intake, smoking, or alcohol use
•Environmental conditions, including exposure to sunlight, natural and medical radiation, workplace
exposures, and involuntary or unknown exposures
•Lack of physical exercise and overweight/obesity
•Sexual practices
•Prescribed and illicit medications
•Socioeconomic factors that affect exposures and susceptibility
•Carcinogenic substances present in air, water, and soil
Question 12: What is leading cause of cancer?
Answer: Cigarette smoking
Question 13: Most Effective HIV Treatment
Answer: Anti-retroviral therapy - a combination of drugs Combination of therapy includes at least 3
drugs, #2 NRTI's (nucleoside reverse transciptase inhibitors) and #1 drug from another class.
Question 14: Defected cells of HIV
Answer: The primary surface receptor on HIV is the envelope glycoprotein gp120, which binds to the
CD4 molecule found mostly on the surface of Thelper cells. The major immunologic finding in AIDS is
the striking decrease in the number of CD4 Th cells
Question 15: Prader-Willi Syndrome
Answer: a rare genetic disorder caused by gene deletions on paternal chromosome 15 that result in short
stature, hypotonia, small hands and feet, obesity, mild to moderate mental retardation, and
hypogonadism.
Question 16: Angelman Syndrome (happy puppet syndrome)
Answer: an inherited syndrome of jerky puppetlike movements, frequent laughter, mental and motor
retardation, peculiar open-mouthed facies, and seizures.
Page 2
