TABLE OF CONTENT
Chapter 1: Pharmacokinetics
Chapter 2: Drug–Receptor Interactions and Pharmacodynamics
Chapter 3: The Autonomic Nervous System
Chapter 4: Cholinergic Agonists
Chapter 5: Cholinergic Antagonists
Chapter 6: Adrenergic Agonists
Chapter 7: Adrenergic Antagonists
Chapter 8: Drugs for Neurodegenerative Diseases
Chapter 9: Anxiolytic and Hypnotic Drugs
Chapter 10: Antidepressants
Chapter 11: Antipsychotic Drugs
Chapter 12: Drugs for Epilepsy
Chapter 13: Anesthetics
Chapter 14: Opioids
Chapter 15: Drugs of Abuse
Chapter 16: CNS Stimulants
Chapter 17: Antihypertensives
Chapter 18: Diuretics
Chapter 19: Heart Failure
Chapter 20: Antiarrhythmics
Chapter 21: Antianginal Drugs
Chapter 22: Anticoagulants and Antiplatelet Agents
Chapter 23: Drugs for Hyperlipidemia
Chapter 24: Pituitary and Thyroid
Chapter 25: Drugs for Diabetes
Chapter 26: Estrogens and Androgens
Chapter 27: Adrenal Hormones
Chapter 28: Drugs for Obesity
Chapter 29: Drugs for Disorders of the Respiratory System
Chapter 30: Antihistamines
Chapter 31: Gastrointestinal and Antiemetic Drugs
Chapter 32: Drugs for Urologic Disorders
Chapter 33: Drugs for Anemia
Chapter 34: Drugs for Dermatologic Disorders
Chapter 35: Drugs for Bone Disorders
Chapter 36: Anti-inflammatory, Antipyretic, and Analgesic Agents
Chapter 37: Principles of Antimicrobial Therapy
Chapter 38: Cell Wall Inhibitors
Chapter 39: Protein Synthesis Inhibitors
Chapter 40: Quinolones, Folic Acid Antagonists, and Urinary Tract Antiseptics
Chapter 41: Antimycobacterial Drugs
Chapter 42: Antifungal Drugs
Chapter 43: Antiprotozoal Drugs
Chapter 44: Anthelmintic Drugs
Chapter 45: Antiviral Drugs
Chapter 46: Anticancer Drugs
Chapter 47: Immunosuppressants
Chapter 48: Clinical Toxicology
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,3. The nurse is teaching a patient who will be discharged home with a prescription for an enteric-
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coated tablet. Which statement by the patient indicates understanding of the teaching?
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a. I may crush the tablet and put it in applesauce to improve absorption.
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b. I should consume acidic foods to enhance absorption of this medication.
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c. I should expect a delay in onset of the drugs effects after taking the tablet.
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d. I should take this medication with high-fat foods to improve its action.
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ANS: C
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Enteric-coated tablets resist disintegration in the acidic environment of the stomach and
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disintegrate when they reach the small intestine. There is usually some delay in onset of actions after
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taking these medications. Enteric-coated tablets should not be crushed or chewed, which would
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alter the time and location of absorption. Acidic foods will not enhance the absorption of the
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medication. The patient should not to eat high-fat food before ingesting an enteric-coated tablet,
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because high-fat foods decrease the absorption rate.
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DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 3
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TOP: NURSING PROCESS: Nursing Intervention
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MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
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4. A patient who is newly diagnosed with type 1 diabetes mellitus asks why insulin must be given
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by subcutaneous injection instead of by mouth. The nurse will explain that this is because
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a. absorption is diminished by the first-pass effects in the liver. V V V V V V V V V
b. absorption is faster when insulin is given subcutaneously. V V V V V V V
c. digestive enzymes in the gastrointestinal tract prevent absorption.
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d. the oral formis less predictable with more adverse effects.
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ANS: C
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Insulin, growth hormones, and other protein-based drugs are destroyed in the small intestine by
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digestive enzymes and must be given parenterally. Because insulin is destroyed by digestive
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enzymes, it would not make it to the liver for metabolism with a first-pass effect. Subcutaneous
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tissue has fewer blood vessels, so absorption is slower in such tissue. Insulin is given
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subcutaneously because it is desirable to have it absorb slowly.
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DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
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TOP: NURSING PROCESS: Nursing Intervention: Patient Teaching
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MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
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, 5. The nurse is preparing to administer an oral medication that is water-soluble. The nurse
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understands that this drug
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a. must be taken on an empty stomach.
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b. requires active transport for absorption. V V V V
c. should be taken with fatty foods. V V V V V
d. will readily diffuse into the gastrointestinal tract.
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ANS: B
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Water-soluble drugs require a carrier enzyme or protein to pass through the GI membrane.
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DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 4
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TOP: NURSING PROCESS: Nursing Intervention
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MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
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6. A nurse is preparing to administer an oral drug that is best absorbed in an acidic environment.
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How will the nurse give the drug?
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a. On an empty stomach
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b. With a full glass of water V V V V V
c. With food V
d. With high-fat food V V
ANS: C
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Food can stimulate the production of gastric acid so medications requiring an acidic environment
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should be given with a meal. High-fat foods are useful for drugs that are lipid soluble.
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DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 4
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TOP: NURSING PROCESS: Nursing Intervention
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MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
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7. The nurse is preparing an injectable drug and wants to administer it for rapid absorption. How will
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the nurse give this medication?
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a. IM into the deltoid muscle
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b. IM into the gluteal muscle
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c. SubQ into abdominal tissue V V V
d. SubQ into the upper arm V V V V
ANS: A
V V
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