COMSAE Phase 1 Form 113 Exam
Practice Questions And Correct Answers
(Verified Answers) Plus Rationales 2026
Q&A | Instant Download Pdf
1. A 24-year-old woman presents with fatigue and pallor. Laboratory
studies reveal microcytic hypochromic anemia with low ferritin levels.
Which of the following is the most likely mechanism responsible for
her anemia?
A. Impaired DNA synthesis due to folate deficiency
B. Reduced iron availability for hemoglobin synthesis
C. Increased destruction of erythrocytes by complement
D. Decreased erythropoietin production
B. Reduced iron availability for hemoglobin synthesis
Iron deficiency anemia results from inadequate iron stores, leading to
impaired hemoglobin production and microcytic hypochromic red blood
cells.
, 2. A patient develops severe hypotension immediately after a bee sting.
Which immunoglobulin mediates this reaction?
A. IgA
B. IgG
C. IgM
D. IgE
D. IgE
Type I hypersensitivity reactions occur when allergens cross-link IgE bound
to mast cells, causing degranulation and release of vasoactive mediators.
3. A researcher inhibits RNA polymerase II in a eukaryotic cell. Which
process will be directly affected?
A. rRNA synthesis
B. tRNA synthesis
C. mRNA synthesis
D. DNA replication
C. mRNA synthesis
RNA polymerase II synthesizes messenger RNA in eukaryotic cells, making
it essential for protein-coding gene transcription.
, 4. A 60-year-old man has chest pain radiating to the left arm. Occlusion
of which coronary artery most commonly causes myocardial
infarction?
A. Left anterior descending artery
B. Right marginal artery
C. Posterior descending artery
D. Circumflex artery
A. Left anterior descending artery
The left anterior descending artery is the most commonly occluded
coronary vessel and supplies much of the anterior wall and interventricular
septum.
5. Which neurotransmitter is primarily deficient in Parkinson disease?
A. Dopamine
B. Serotonin
C. Acetylcholine
D. GABA
A. Dopamine
Degeneration of dopaminergic neurons in the substantia nigra leads to
decreased dopamine levels in the basal ganglia.
, 6. A patient with chronic alcoholism develops confusion,
ophthalmoplegia, and ataxia. Deficiency of which vitamin is most
likely?
A. Vitamin B12
B. Vitamin C
C. Thiamine
D. Riboflavin
C. Thiamine
Thiamine deficiency causes Wernicke encephalopathy, characterized by
confusion, ophthalmoplegia, and ataxia.
7. A child has recurrent infections with catalase-positive organisms.
Defective NADPH oxidase activity is present. What is the diagnosis?
A. Chediak-Higashi syndrome
B. Chronic granulomatous disease
C. DiGeorge syndrome
D. Severe combined immunodeficiency
B. Chronic granulomatous disease
Chronic granulomatous disease results from defective respiratory burst
activity due to NADPH oxidase deficiency.
Practice Questions And Correct Answers
(Verified Answers) Plus Rationales 2026
Q&A | Instant Download Pdf
1. A 24-year-old woman presents with fatigue and pallor. Laboratory
studies reveal microcytic hypochromic anemia with low ferritin levels.
Which of the following is the most likely mechanism responsible for
her anemia?
A. Impaired DNA synthesis due to folate deficiency
B. Reduced iron availability for hemoglobin synthesis
C. Increased destruction of erythrocytes by complement
D. Decreased erythropoietin production
B. Reduced iron availability for hemoglobin synthesis
Iron deficiency anemia results from inadequate iron stores, leading to
impaired hemoglobin production and microcytic hypochromic red blood
cells.
, 2. A patient develops severe hypotension immediately after a bee sting.
Which immunoglobulin mediates this reaction?
A. IgA
B. IgG
C. IgM
D. IgE
D. IgE
Type I hypersensitivity reactions occur when allergens cross-link IgE bound
to mast cells, causing degranulation and release of vasoactive mediators.
3. A researcher inhibits RNA polymerase II in a eukaryotic cell. Which
process will be directly affected?
A. rRNA synthesis
B. tRNA synthesis
C. mRNA synthesis
D. DNA replication
C. mRNA synthesis
RNA polymerase II synthesizes messenger RNA in eukaryotic cells, making
it essential for protein-coding gene transcription.
, 4. A 60-year-old man has chest pain radiating to the left arm. Occlusion
of which coronary artery most commonly causes myocardial
infarction?
A. Left anterior descending artery
B. Right marginal artery
C. Posterior descending artery
D. Circumflex artery
A. Left anterior descending artery
The left anterior descending artery is the most commonly occluded
coronary vessel and supplies much of the anterior wall and interventricular
septum.
5. Which neurotransmitter is primarily deficient in Parkinson disease?
A. Dopamine
B. Serotonin
C. Acetylcholine
D. GABA
A. Dopamine
Degeneration of dopaminergic neurons in the substantia nigra leads to
decreased dopamine levels in the basal ganglia.
, 6. A patient with chronic alcoholism develops confusion,
ophthalmoplegia, and ataxia. Deficiency of which vitamin is most
likely?
A. Vitamin B12
B. Vitamin C
C. Thiamine
D. Riboflavin
C. Thiamine
Thiamine deficiency causes Wernicke encephalopathy, characterized by
confusion, ophthalmoplegia, and ataxia.
7. A child has recurrent infections with catalase-positive organisms.
Defective NADPH oxidase activity is present. What is the diagnosis?
A. Chediak-Higashi syndrome
B. Chronic granulomatous disease
C. DiGeorge syndrome
D. Severe combined immunodeficiency
B. Chronic granulomatous disease
Chronic granulomatous disease results from defective respiratory burst
activity due to NADPH oxidase deficiency.
