NR 546 Psychopharmacology Final Exam Version 1 & Version 2: (Latest 2025
Actual Exam) Complete Q&A | 100% Correct | Verified | Grade A+
Subject: Psychopharmacology (NR 546) – Final Exam: Bipolar Disorder, Major Depressive Disorder,
Antidepressants, Mood Stabilizers, ADHD, Substance Use Disorders, Alzheimer's Disease, Insomnia,
Anxiety Disorders
Source: Actual Exam Blueprint – Lithium, Anticonvulsants, SGAs, SSRIs/SNRIs, MAOIs, MAT for
OUD/AUD, Stimulants, Non-Stimulants, Sleep Medications, Dementia Treatments
Format: Q&A Study Guide with Rationale – 100% Verified Answers
Verified: Latest 2025 Actual Exam | Grade A+ Guaranteed
1: What are the pharmacologic treatments for Bipolar Disorder?
Correct Answer: Lithium, anticonvulsants (valproate, lamotrigine, carbamazepine), and second-
generation antipsychotics (aripiprazole, cariprazine, lurasidone, quetiapine, asenapine, risperidone,
olanzapine, ziprasidone).
1. Lithium is first-line for acute mania and maintenance; reduces suicide risk.
2. Valproate for acute mania/mixed episodes; lamotrigine for bipolar depression maintenance.
3. SGAs indicated for acute mania, mixed episodes, bipolar depression, or maintenance.
2: What are the required laboratory tests for lithium therapy?
Correct Answer: Serum lithium level (therapeutic: acute 1.0-1.5 mEq/L; maintenance 0.6-1.2 mEq/L),
renal function (BUN, Cr), thyroid function (TSH, free T4).
1. Lithium has narrow therapeutic index; monitor levels 5 days after dose change, then q6-12
months.
Renal toxicity; monitor annually.
3. Thyroid dysfunction common; monitor TSH annually.
3: First-line combination therapy for bipolar I disorder with manic and depressive features?
Correct Answer: Lithium OR Valproic Acid + Lamotrigine OR Aripiprazole OR Risperidone.
1. Combination therapy for mixed episodes or rapid cycling.
2. Lamotrigine effective for bipolar depression maintenance.
3. Aripiprazole and risperidone effective for acute mania and maintenance.
4: Which medication would require genetic testing in an Asian client with bipolar disorder?
Carbamazepine
Correct Answer: Carbamazepine (screen for HLA-B*1502 allele – increased risk of Stevens-Johnson
syndrome)
1. HLA-B*1502 allele present in 10-15% of Asian population.
2. Positive allele contraindicates carbamazepine.
3. Alternative mood stabilizers (lithium, valproate, lamotrigine) without this risk.
Actual Exam) Complete Q&A | 100% Correct | Verified | Grade A+
Subject: Psychopharmacology (NR 546) – Final Exam: Bipolar Disorder, Major Depressive Disorder,
Antidepressants, Mood Stabilizers, ADHD, Substance Use Disorders, Alzheimer's Disease, Insomnia,
Anxiety Disorders
Source: Actual Exam Blueprint – Lithium, Anticonvulsants, SGAs, SSRIs/SNRIs, MAOIs, MAT for
OUD/AUD, Stimulants, Non-Stimulants, Sleep Medications, Dementia Treatments
Format: Q&A Study Guide with Rationale – 100% Verified Answers
Verified: Latest 2025 Actual Exam | Grade A+ Guaranteed
1: What are the pharmacologic treatments for Bipolar Disorder?
Correct Answer: Lithium, anticonvulsants (valproate, lamotrigine, carbamazepine), and second-
generation antipsychotics (aripiprazole, cariprazine, lurasidone, quetiapine, asenapine, risperidone,
olanzapine, ziprasidone).
1. Lithium is first-line for acute mania and maintenance; reduces suicide risk.
2. Valproate for acute mania/mixed episodes; lamotrigine for bipolar depression maintenance.
3. SGAs indicated for acute mania, mixed episodes, bipolar depression, or maintenance.
2: What are the required laboratory tests for lithium therapy?
Correct Answer: Serum lithium level (therapeutic: acute 1.0-1.5 mEq/L; maintenance 0.6-1.2 mEq/L),
renal function (BUN, Cr), thyroid function (TSH, free T4).
1. Lithium has narrow therapeutic index; monitor levels 5 days after dose change, then q6-12
months.
Renal toxicity; monitor annually.
3. Thyroid dysfunction common; monitor TSH annually.
3: First-line combination therapy for bipolar I disorder with manic and depressive features?
Correct Answer: Lithium OR Valproic Acid + Lamotrigine OR Aripiprazole OR Risperidone.
1. Combination therapy for mixed episodes or rapid cycling.
2. Lamotrigine effective for bipolar depression maintenance.
3. Aripiprazole and risperidone effective for acute mania and maintenance.
4: Which medication would require genetic testing in an Asian client with bipolar disorder?
Carbamazepine
Correct Answer: Carbamazepine (screen for HLA-B*1502 allele – increased risk of Stevens-Johnson
syndrome)
1. HLA-B*1502 allele present in 10-15% of Asian population.
2. Positive allele contraindicates carbamazepine.
3. Alternative mood stabilizers (lithium, valproate, lamotrigine) without this risk.
