COMSAE Phase 1 Form 113 Practice Exam With
Actual Questions & Verified Answers, Plus
Explained Rationales/Expert Verified For
Guaranteed 100% Pass 2026/Latest
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1. A 65-year-old man presents with resting tremor, bradykinesia,
and rigidity. Which neurotransmitter deficiency is primarily
responsible for his symptoms?
A. Acetylcholine
B. Dopamine
C. Serotonin
D. GABA
B. Dopamine
Rationale: Parkinson disease is caused by degeneration of
dopaminergic neurons in the substantia nigra, leading to
decreased dopamine levels.
2. A 23-year-old woman presents with fever, malar rash, and joint
pain. Which antibody is most specific for her condition?
A. Anti-dsDNA
B. Anti-Smith
C. ANA
D. Anti-histone
B. Anti-Smith
Rationale: Anti-Smith antibodies are highly specific for systemic
lupus erythematosus, although less sensitive.
3. A patient with chronic alcohol use develops confusion, ataxia, and
ophthalmoplegia. What is the most likely diagnosis?
, A. Korsakoff syndrome
B. Wernicke encephalopathy
C. Delirium tremens
D. Hepatic encephalopathy
B. Wernicke encephalopathy
Rationale: Wernicke encephalopathy results from thiamine
deficiency and presents with the classic triad.
4. Which structure is responsible for producing surfactant in the
lungs?
A. Type I pneumocytes
B. Type II pneumocytes
C. Alveolar macrophages
D. Bronchial epithelial cells
B. Type II pneumocytes
Rationale: Type II pneumocytes produce surfactant, which
reduces alveolar surface tension.
5. A newborn presents with projectile vomiting and an olive-shaped
mass. What is the diagnosis?
A. Intussusception
B. Pyloric stenosis
C. Hirschsprung disease
D. Malrotation
B. Pyloric stenosis
Rationale: Hypertrophic pyloric stenosis presents with projectile
vomiting and palpable mass.
6. Which electrolyte abnormality is most associated with peaked T
waves on ECG?
A. Hypokalemia
B. Hyperkalemia
, C. Hypocalcemia
D. Hypernatremia
B. Hyperkalemia
Rationale: Hyperkalemia causes peaked T waves due to altered
cardiac conduction.
7. A patient with COPD has chronic CO2 retention. What
compensatory mechanism occurs?
A. Decreased bicarbonate
B. Increased bicarbonate
C. Respiratory alkalosis
D. Metabolic alkalosis
B. Increased bicarbonate
Rationale: Kidneys retain bicarbonate to compensate for chronic
respiratory acidosis.
8. Which vitamin deficiency causes scurvy?
A. Vitamin A
B. Vitamin B12
C. Vitamin C
D. Vitamin D
C. Vitamin C
Rationale: Vitamin C deficiency impairs collagen synthesis,
leading to scurvy.
9. A patient presents with hyperpigmentation and hypotension.
Which hormone is deficient?
A. Cortisol
B. Aldosterone
C. ACTH
D. Insulin
A. Cortisol
Actual Questions & Verified Answers, Plus
Explained Rationales/Expert Verified For
Guaranteed 100% Pass 2026/Latest
Update/Instant Download Pdf
1. A 65-year-old man presents with resting tremor, bradykinesia,
and rigidity. Which neurotransmitter deficiency is primarily
responsible for his symptoms?
A. Acetylcholine
B. Dopamine
C. Serotonin
D. GABA
B. Dopamine
Rationale: Parkinson disease is caused by degeneration of
dopaminergic neurons in the substantia nigra, leading to
decreased dopamine levels.
2. A 23-year-old woman presents with fever, malar rash, and joint
pain. Which antibody is most specific for her condition?
A. Anti-dsDNA
B. Anti-Smith
C. ANA
D. Anti-histone
B. Anti-Smith
Rationale: Anti-Smith antibodies are highly specific for systemic
lupus erythematosus, although less sensitive.
3. A patient with chronic alcohol use develops confusion, ataxia, and
ophthalmoplegia. What is the most likely diagnosis?
, A. Korsakoff syndrome
B. Wernicke encephalopathy
C. Delirium tremens
D. Hepatic encephalopathy
B. Wernicke encephalopathy
Rationale: Wernicke encephalopathy results from thiamine
deficiency and presents with the classic triad.
4. Which structure is responsible for producing surfactant in the
lungs?
A. Type I pneumocytes
B. Type II pneumocytes
C. Alveolar macrophages
D. Bronchial epithelial cells
B. Type II pneumocytes
Rationale: Type II pneumocytes produce surfactant, which
reduces alveolar surface tension.
5. A newborn presents with projectile vomiting and an olive-shaped
mass. What is the diagnosis?
A. Intussusception
B. Pyloric stenosis
C. Hirschsprung disease
D. Malrotation
B. Pyloric stenosis
Rationale: Hypertrophic pyloric stenosis presents with projectile
vomiting and palpable mass.
6. Which electrolyte abnormality is most associated with peaked T
waves on ECG?
A. Hypokalemia
B. Hyperkalemia
, C. Hypocalcemia
D. Hypernatremia
B. Hyperkalemia
Rationale: Hyperkalemia causes peaked T waves due to altered
cardiac conduction.
7. A patient with COPD has chronic CO2 retention. What
compensatory mechanism occurs?
A. Decreased bicarbonate
B. Increased bicarbonate
C. Respiratory alkalosis
D. Metabolic alkalosis
B. Increased bicarbonate
Rationale: Kidneys retain bicarbonate to compensate for chronic
respiratory acidosis.
8. Which vitamin deficiency causes scurvy?
A. Vitamin A
B. Vitamin B12
C. Vitamin C
D. Vitamin D
C. Vitamin C
Rationale: Vitamin C deficiency impairs collagen synthesis,
leading to scurvy.
9. A patient presents with hyperpigmentation and hypotension.
Which hormone is deficient?
A. Cortisol
B. Aldosterone
C. ACTH
D. Insulin
A. Cortisol
