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Summary

Summary Anti-Malarials Pharmacology

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47 pages
2025/2026 Written for academic year
Institution University Of KwaZulu-Natal (UKZN)
Course Pharmacology (PHRM362)
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This document contains concise, exam-focused summary notes on Anti-Malarial Drugs for undergraduate pharmacy and health-science students. The notes cover all core antimalarial agents, including chloroquine, quinine, artemisinin derivatives, mefloquine, primaquine, and atovaquone–proguanil, presented in a clear and structured manner. Each drug is discussed with emphasis on mechanism of action, pharmacokinetics, clinical uses, adverse effects, contraindications, resistance, and special considerations such as pregnancy and G6PD deficiency. The document also includes summary tables and self-test questions to support revision and exam preparation. These student-made notes are ideal for quick review, concept clarification, and high-yield exam study.

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PHARMACOLOGY
ANTI-MALARIALS
COMPILED BY SOHIL SIDHLALL

, DISCLAIMER
These notes are independently prepared, student-made
study summaries created for educational purposes.
The content is based on standard pharmacology
references, including Katzung’s Basic and Clinical
Pharmacology (12th Edition), but is written entirely in
the author’s own words.
These notes are not copied from, endorsed by, or
affiliated with any textbook, author, publisher, or
institution.

,MEDICATION
Quinine
Chloroquine
Artemisinin and Its Derivatives
Mefloquine
Primaquine
Halofantrine

, QUININE
The first antimalarial drug was discovered in the early 1820s, originally
used to treat fevers.
It’s a natural alkaloid extracted from the bark of the Cinchona tree.
Quinidine is the dextrorotatory isomer of quinine and shares similar
pharmacologic actions.

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