CEN TOXICOLOGY LATEST
STUDY GUIDE
Anticholinergics [not producing fluids/blood to heart, lungs and brain]
syndrome
(antihistamines, bronchodilators, cyclic antidepressants, SLEEP AIDS) -
ANSWERS-Hot as a hare (hyperthermia)
Red as a beet (flushed)
Dry as a bone [ANHYDROSIS (dry skin, urinary retention)
Blind as a bat (mydriasis)
Mad as a hatter (hallucinations, delirium, myoclonic jerking)
The antidote for anticholinergic toxicity is physostigmine salicylate.
Physostigmine is the only reversible acetylcholinesterase inhibitor
capable of directly antagonizing the CNS manifestations of
anticholinergic toxicity; it is an uncharged tertiary amine that efficiently
crosses the blood-brain barrier
What does muscular rigidity cause - ANSWERS-rhabdomylosis
syndrome due to a direct or indirect muscle injury. It results from the
death of muscle fibers and release of their contents into the bloodstream
(myoglobin). This can lead to renal (kidney) failure.
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, CEN TOXICOLOGY LATEST
STUDY GUIDE
sympathomimetic [fight or flight/shunt blood going to heart/brain/lungs]
- ANSWERS-MIMIC SYMPATHETIC
a drug that stimulates the sympathetic branch of the autonomic nervous
system
Epinephrine, adrenaline
Organophosphate poisoning
Cholinergics {see, spit, pee, shit] used in pesticides b/c - ANSWERS-
BUGS DROWN with Cholinergic [producing fluids: saliva, urine,
digestive enzymes]
Organophosphates are used as insecticides, medications, and nerve
agents. Symptoms include increased saliva and tear production, diarrhea,
vomiting, small pupils, sweating, muscle tremors, and confusion.
Cholinergics {see, spit, pee, shit] pathway - ANSWERS-muscuric and
nicotinic receptors that use acetylcholine neurotransmitters
cholinergic cells that use which neurotransmitter - ANSWERS-Referring
to cells that use acetylcholine as their synaptic transmitter.
SLUDGE-bbb - ANSWERS-Muscarinic Cholinergic syndrome
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, CEN TOXICOLOGY LATEST
STUDY GUIDE
Salvation
lacrimination
urination
defecation
gastric emesis
bronchoria
bronchospasm
bradycardia
miosis
increased bowel sounds
Cholinergic Drug toxicity
antidote - ANSWERS-2-PAM
Atropine
anticholinergic over dose examples - ANSWERS-Atropine
antihistamines [benadryl]
TCAs Tricyclic antidepressants (Amitriptyline)
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PAGE
3
STUDY GUIDE
Anticholinergics [not producing fluids/blood to heart, lungs and brain]
syndrome
(antihistamines, bronchodilators, cyclic antidepressants, SLEEP AIDS) -
ANSWERS-Hot as a hare (hyperthermia)
Red as a beet (flushed)
Dry as a bone [ANHYDROSIS (dry skin, urinary retention)
Blind as a bat (mydriasis)
Mad as a hatter (hallucinations, delirium, myoclonic jerking)
The antidote for anticholinergic toxicity is physostigmine salicylate.
Physostigmine is the only reversible acetylcholinesterase inhibitor
capable of directly antagonizing the CNS manifestations of
anticholinergic toxicity; it is an uncharged tertiary amine that efficiently
crosses the blood-brain barrier
What does muscular rigidity cause - ANSWERS-rhabdomylosis
syndrome due to a direct or indirect muscle injury. It results from the
death of muscle fibers and release of their contents into the bloodstream
(myoglobin). This can lead to renal (kidney) failure.
END OF
PAGE
1
, CEN TOXICOLOGY LATEST
STUDY GUIDE
sympathomimetic [fight or flight/shunt blood going to heart/brain/lungs]
- ANSWERS-MIMIC SYMPATHETIC
a drug that stimulates the sympathetic branch of the autonomic nervous
system
Epinephrine, adrenaline
Organophosphate poisoning
Cholinergics {see, spit, pee, shit] used in pesticides b/c - ANSWERS-
BUGS DROWN with Cholinergic [producing fluids: saliva, urine,
digestive enzymes]
Organophosphates are used as insecticides, medications, and nerve
agents. Symptoms include increased saliva and tear production, diarrhea,
vomiting, small pupils, sweating, muscle tremors, and confusion.
Cholinergics {see, spit, pee, shit] pathway - ANSWERS-muscuric and
nicotinic receptors that use acetylcholine neurotransmitters
cholinergic cells that use which neurotransmitter - ANSWERS-Referring
to cells that use acetylcholine as their synaptic transmitter.
SLUDGE-bbb - ANSWERS-Muscarinic Cholinergic syndrome
END OF
PAGE
2
, CEN TOXICOLOGY LATEST
STUDY GUIDE
Salvation
lacrimination
urination
defecation
gastric emesis
bronchoria
bronchospasm
bradycardia
miosis
increased bowel sounds
Cholinergic Drug toxicity
antidote - ANSWERS-2-PAM
Atropine
anticholinergic over dose examples - ANSWERS-Atropine
antihistamines [benadryl]
TCAs Tricyclic antidepressants (Amitriptyline)
END OF
PAGE
3
