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, Koeppen: Berne and Levy Physiology, 7th Edition h1 h1 h1 h1 h1 h1
Chapter 01: Principles of Cell h1 h1 h1 h1
FunctionTest Bank
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Multiple Choice h1
1. The subcellular structure that degrades proteins is called the:
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A. Tight junction h1
B. Mitochondria
C. Lysosome
D. Plasma membrane h1
E. Ribosome
ANS: C
2. An experiment is done to measure the uptake of an amino acid into a cell. The
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following data are obtained:
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N
If Na+ is removed from the extracellular bathing solution, or if a drug is added that prevents
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the cell from making adenosine triphosphate (ATP), the uptake of amino acid into the
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cell is markedly reduced. According to this information, which of the
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followingmechanisms is probably responsible for the transport of the amino acid into
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the cell?
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A. Passive diffusion through the lipid bilayer h1 h1 h1 h1 h1
B. Uniporter
C. Transport ATPase h1
D. Na+ symporter h1
E. Na+antiporter
ANS: D
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3. Amembrane permeable byonly Na+ separatestwo compartments
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containing Na2SO4,shown as follows:
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,Electrodes are placed in both compartments, and a voltage is applied (that of
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compartment A is held at 0 mV). What voltage applied to compartment B would
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resultin no net movement of Na+ across the membrane separating the compartments?
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–60 mV
A. h1
–30 mV
B. h1
C.
0 mV h1
D. +30 mV h1
E. +60mV
ANS: E h 1 h 1
4. The restingmembrane potentNial oRf a Ic ellGis –B
h1 85.mCV. The intracellular and h1 h1 h1 h1 h 1 h 1 h1 h1
extracellular concentrations ofUseveral
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SN ions are indicated in the following table,
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1
h 1
h
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as is the calculated
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Nernst equilibrium potential (Ei) for each of these ions:
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Ion Concentration Concentration Ei
Inside Cell h1 Outside Cell h1
+
Na 12 mEq/L h1 145 mEq/L h1 66 mV h1
K+ 150 mEq/L h1 4 mEq/L h1 –96 mV h1
Cl– 30 mEq/L h1 105 mEq/L h1 –33 mV h1
Ca++ 0.0001 mmol/dL h1 1 mmol/dLh1 122 mV h1
The membrane has channels for Na+, K+, Cl–, and Ca++. The conductance of the
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membrane is the greatest for which ion?
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A. Na+
B. K+
C. Cl–
D. Ca++
AN h 1
S:
B
5. A cell contains the following membrane transporters:
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Na+channelK+channel
1
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Na+,K+-ATPase
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The resting membrane voltage of the cell is –80 mV, and the intracellular and
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, extracellular ion concentrations are as follows:
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Ion Intracellular Extracellular
Concentration Concentration
Na+ 10 mEq/L h1 145 mEq/L h1
K+ 120 mEq/L h1 4 mEq/L h1
The cell is treated with a drug to inhibit the Na+,K+-ATPase. What would be the effect ofthis drug on
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the following parameters?
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Intracellular [Na+] h1 Intracellular [K+] h1 Cell Volumeh1 Membrane Voltage h1
A. Decrease Decrease Decrease Depolarize
B. Increase Decrease Increase Depolarize
C. Increase Increase Increase No change
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D. Decrease Increase Decrease Hyperpolarize
E. Increase Increase Decrease Hyperpolarize
ANS: B
6. Which of the labeled proteins (shaded) is attached to the membrane by
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a glycosylphosphatidylinositol (GPI) anchor?
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ANS: E
7. A cell has channels for Na+, K+, and Cl– in its plasma membrane. The resting
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h 1
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membrane potential is –60 mV (cell interior negative). The intracellular and
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extracellular concentrations for these ions, as well as the calculated Nernst
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potentials, are listed as follows:
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