Test Bank For Cellular and Molecular Immunology, 11th Edition by Abul K. Abbas| Verified Chapters 1-21|| Latest Edition 2025

,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules
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Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 11th Edition
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MULTIPLE CHOICE Xf




1. The principal function of the immune system is:
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a. Defense against cancer Xf Xf


b. Repair of injured tissues Xf Xf Xf


c. Defense against microbial infections Xf Xf Xf


d. Prevention of inflammatory diseases Xf Xf Xf


e. Protection against environmental toxins Xf Xf Xf




ANS: C X f


The immune system has evolved in the setting of selective pressures imposed by microbi
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al infections. Although immune responses to cancer may occur, the concept that ―immu
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nosurveillance‖ against cancer is a principal function of the immune system is controver
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sial. Repair of injured tissues may be a secondary consequence of the immune response
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s and inflammation. Although the immune system has regulatory features that are neede
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d to prevent excessive inflammation, prevention of inflammatory diseases is not a prima
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ry function. The immune system can protect against microbial toxins, but it generally doe
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s not offer protection against toxins of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successf
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ul vaccination?
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a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C X f


In 1798, Edward Jenner reported the first intentional successful vaccination, which was
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against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 19
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80, smallpox was reported to be eradicated worldwide by a vaccination program. Effecti
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ve vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20
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th century and are widely used. There is no effective vaccine against Mycobacterium tu
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berculosis.

3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens
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b. Self-nonself discrimination Xf


c. Recognition of microbial structures by both cell-associated and soluble receptors
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d. Protection against viral infections Xf Xf Xf


e. Responses that have the same kinetics and magnitude on repeated exposure to t
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he same microbe Xf Xf




ANS: X f A

, Highly diverse repertoires of specificities for antigens are found only in T and B lymph
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ocytes, which are the central cellular components of the adaptive immune system. Both
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the innate and the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same mi
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crobe, the adaptive immune response becomes more rapid and of greater magnitude; this
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is the manifestation of memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types
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of immunity?
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a. Innate and adaptive Xf Xf


b. Passive and active Xf Xf


c. Specific and nonspecific Xf Xf


d. Humoral and cell-mediated Xf Xf


e. Adult and neonatal Xf Xf




ANS: D X f


Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyt
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es produce antibodies, which are the recognition and effector molecules of humoral imm
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une responses to extracellular pathogens. T cells recognize and promote eradication of int
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racellular pathogens in cell- Xf Xf Xf


mediated immunity. Passive and active immunity both can be mediated by either B or T l
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ymphocytes. Specific immunity is another term for adaptive immunity. Both B and T lym
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phocytes participate in adult adaptive immunity but are still developing in the neonatal p
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eriod.

5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes
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b. Natural killer cells and cytoWtoWxW
ic.TTlB
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cyStes
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c. Memory T cells and effector T cells Xf Xf Xf Xf Xf Xf


d. Helper cells and antigen-presenting cells Xf Xf Xf Xf


e. Cytotoxic T lymphocytes and target cells Xf Xf Xf Xf Xf




ANS: A X f


T cells can be classified into effector subsets that perform different effector functions. M
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ost effector T cells are either helper T lymphocytes, which enhance the responses of oth
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er immune cells, including phagocytes and B cells, to infections, or cytotoxic T lympho
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cytes, which directly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. Xf Xf Xf Xf Xf Xf Xf Xf Xf Xf Xf Xf Xf Xf




6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells Xf Xf


b. Dendritic cells Xf


c. Cytolytic T lymphocytes Xf Xf


d. B lymphocytes Xf


e. Helper T lymphocytes Xf Xf




ANS: D X f


Humoral immune responses are antibody- Xf Xf Xf Xf


mediated immune responses, and all antibodies are made by B lymphocytes and no ot
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her cell type.
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