TEST BANK
Cellular and Molecular Immunology 11th
Edition
by Abul K. Abbas MBBS (Author), Andrew H. Lichtman MD PhD (Author), & 2 more
,TABLE OF CONTENTS
1 Overview of the Immune System
2 Cells and Tissues of the Immune System
3 Leukocyte Circulation and Migration Into Tissues
4 Innate Immunity
5 Antibodies and Antigens
6 Antigen Presentation to T Lymphocytes and the Role of Major
Histocompatibility Complex Molecules
7 Immune Receptors and Signal Transduction
8 Lymphocyte Development and Antigen Receptor Gene Rearrangement
9 Activation and Regulation of T Lymphocytes
10 Differentiation and Functions of CD4 + Effector T Cells
11 Differentiation and Functions of CD8 + Effector T Cells
12 B-Cell Activation and Antibody Production
13 Effector Mechanisms of Humoral Immunity
14 Specialized Immunity at Epithelial Barriers and in Immune-Privileged Tissues
15 Immunologic Tolerance and Autoimmunity
16 Immunity to Microbes
17 Transplantation Immunology
18 Tumor Immunology
19 Hypersensitivity Disorders
20 Allergy
21 Congenital and Acquired Immunodeficiencies
,Chapter 01: Properties And Overview Of Immune Responses
Abbas, Lichtman, And Pillai: Cellular And Molecular Immunology, 11th Edition
MULTIPLE CHOICE
1. The Principal Function Of The Immune System Is:
A. Defense Against Cancer
B. Repair Of Injured Tissues
C. Defense Against Microbial Infections
D. Prevention Of Inflammatory Diseases
E. Protection Against Environmental Toxins
ANSWER; C
The Immune System Has Evolved In The Setting Of Selective Pressures Imposed By Microbial Infections.
Although Immune Responses To Cancer May Occur, The Concept That “Immunosurveillance” Against
Cancer Is A Principal Function Of The Immune System Is Controversial. Repair Of Injured Tissues May Be
A Secondary Consequence Of The Immune Responses And Inflammation. Although The Immune System
Has Regulatory Features That Are Needed To Prevent Excessive Inflammation, Prevention Of
Inflammatory Diseases Is Not A Primary Function. The Immune System Can Protect Against Microbial
Toxins, But It Generally Does Not Offer Protection Against Toxins Of Nonbiologic Origin.
2. Which Of The Following Infectious Diseases Was Prevented By The First Successful Vaccination?
A. Polio
B. Tuberculosis
C. Smallpox
D. Tetanus
E. Rubella
ANSWER; C
In 1798, Edward Jenner Reported The First Intentional Successful Vaccination, Which Was Against
Smallpox In A Boy, Using Material From The Cowpox Pustules Of A Milkmaid. In 1980, Smallpox Was
Reported To Be Eradicated Worldwide By A Vaccination Program. Effective Vaccines Against Tetanus
, Toxin, Rubella Virus, And Poliovirus Were Developed In The 20th Century And Are Widely Used. There Is
No Effective Vaccine Against Mycobacterium Tuberculosis.
3. Which Of The Following Is A Unique Property Of The Adaptive Immune System?
A. Highly Diverse Repertoire Of Specificities For Antigens
B. Self-Nonself Discrimination
C. Recognition Of Microbial Structures By Both Cell-Associated And Soluble Receptors
D. Protection Against Viral Infections
E. Responses That Have The Same Kinetics And Magnitude On Repeated Exposure To The Same
Microbe
ANSWER; A
Highly Diverse Repertoires Of Specificities For Antigens Are Found Only In T And B Lymphocytes, Which
Are The Central Cellular Components Of The Adaptive Immune System. Both The Innate And The
Adaptive Immune Systems Use Cell-Associated And Soluble Receptors To Recognize Microbes, Display
Some Degree Of Self-Nonself Discrimination, And Protect Against Viruses. On Repeated Exposure To The
Same Microbe, The Adaptive Immune Response Becomes More Rapid And Of Greater Magnitude; This Is
The Manifestation Of Memory.
4. Antibodies And T Lymphocytes Are The Respective Mediators Of Which Two Types Of
Immunity?
A. Innate And Adaptive
B. Passive And Active
C. Specific And Nonspecific
D. Humoral And Cell-Mediated
E. Adult And Neonatal
ANSWER; D
Both B And T Lymphocytes Are Principal Components Of Adaptive Immunity. B Lymphocytes Produce
Antibodies, Which Are The Recognition And Effector Molecules Of Humoral Immune Responses To
Extracellular Pathogens. T Cells Recognize And Promote Eradication Of Intracellular Pathogens In Cell-
Mediated Immunity. Passive And Active Immunity Both Can Be Mediated By Either B Or T Lymphocytes.
Specific Immunity Is Another Term For Adaptive Immunity. Both B And T Lymphocytes Participate In
Adult Adaptive Immunity But Are Still Developing In The Neonatal Period.
Cellular and Molecular Immunology 11th
Edition
by Abul K. Abbas MBBS (Author), Andrew H. Lichtman MD PhD (Author), & 2 more
,TABLE OF CONTENTS
1 Overview of the Immune System
2 Cells and Tissues of the Immune System
3 Leukocyte Circulation and Migration Into Tissues
4 Innate Immunity
5 Antibodies and Antigens
6 Antigen Presentation to T Lymphocytes and the Role of Major
Histocompatibility Complex Molecules
7 Immune Receptors and Signal Transduction
8 Lymphocyte Development and Antigen Receptor Gene Rearrangement
9 Activation and Regulation of T Lymphocytes
10 Differentiation and Functions of CD4 + Effector T Cells
11 Differentiation and Functions of CD8 + Effector T Cells
12 B-Cell Activation and Antibody Production
13 Effector Mechanisms of Humoral Immunity
14 Specialized Immunity at Epithelial Barriers and in Immune-Privileged Tissues
15 Immunologic Tolerance and Autoimmunity
16 Immunity to Microbes
17 Transplantation Immunology
18 Tumor Immunology
19 Hypersensitivity Disorders
20 Allergy
21 Congenital and Acquired Immunodeficiencies
,Chapter 01: Properties And Overview Of Immune Responses
Abbas, Lichtman, And Pillai: Cellular And Molecular Immunology, 11th Edition
MULTIPLE CHOICE
1. The Principal Function Of The Immune System Is:
A. Defense Against Cancer
B. Repair Of Injured Tissues
C. Defense Against Microbial Infections
D. Prevention Of Inflammatory Diseases
E. Protection Against Environmental Toxins
ANSWER; C
The Immune System Has Evolved In The Setting Of Selective Pressures Imposed By Microbial Infections.
Although Immune Responses To Cancer May Occur, The Concept That “Immunosurveillance” Against
Cancer Is A Principal Function Of The Immune System Is Controversial. Repair Of Injured Tissues May Be
A Secondary Consequence Of The Immune Responses And Inflammation. Although The Immune System
Has Regulatory Features That Are Needed To Prevent Excessive Inflammation, Prevention Of
Inflammatory Diseases Is Not A Primary Function. The Immune System Can Protect Against Microbial
Toxins, But It Generally Does Not Offer Protection Against Toxins Of Nonbiologic Origin.
2. Which Of The Following Infectious Diseases Was Prevented By The First Successful Vaccination?
A. Polio
B. Tuberculosis
C. Smallpox
D. Tetanus
E. Rubella
ANSWER; C
In 1798, Edward Jenner Reported The First Intentional Successful Vaccination, Which Was Against
Smallpox In A Boy, Using Material From The Cowpox Pustules Of A Milkmaid. In 1980, Smallpox Was
Reported To Be Eradicated Worldwide By A Vaccination Program. Effective Vaccines Against Tetanus
, Toxin, Rubella Virus, And Poliovirus Were Developed In The 20th Century And Are Widely Used. There Is
No Effective Vaccine Against Mycobacterium Tuberculosis.
3. Which Of The Following Is A Unique Property Of The Adaptive Immune System?
A. Highly Diverse Repertoire Of Specificities For Antigens
B. Self-Nonself Discrimination
C. Recognition Of Microbial Structures By Both Cell-Associated And Soluble Receptors
D. Protection Against Viral Infections
E. Responses That Have The Same Kinetics And Magnitude On Repeated Exposure To The Same
Microbe
ANSWER; A
Highly Diverse Repertoires Of Specificities For Antigens Are Found Only In T And B Lymphocytes, Which
Are The Central Cellular Components Of The Adaptive Immune System. Both The Innate And The
Adaptive Immune Systems Use Cell-Associated And Soluble Receptors To Recognize Microbes, Display
Some Degree Of Self-Nonself Discrimination, And Protect Against Viruses. On Repeated Exposure To The
Same Microbe, The Adaptive Immune Response Becomes More Rapid And Of Greater Magnitude; This Is
The Manifestation Of Memory.
4. Antibodies And T Lymphocytes Are The Respective Mediators Of Which Two Types Of
Immunity?
A. Innate And Adaptive
B. Passive And Active
C. Specific And Nonspecific
D. Humoral And Cell-Mediated
E. Adult And Neonatal
ANSWER; D
Both B And T Lymphocytes Are Principal Components Of Adaptive Immunity. B Lymphocytes Produce
Antibodies, Which Are The Recognition And Effector Molecules Of Humoral Immune Responses To
Extracellular Pathogens. T Cells Recognize And Promote Eradication Of Intracellular Pathogens In Cell-
Mediated Immunity. Passive And Active Immunity Both Can Be Mediated By Either B Or T Lymphocytes.
Specific Immunity Is Another Term For Adaptive Immunity. Both B And T Lymphocytes Participate In
Adult Adaptive Immunity But Are Still Developing In The Neonatal Period.
