TEST BANK nc
Cellular and Molecular Immunology
nc nc nc
Abul Abbas, Andrew Lichtman, and Shiv Pillai
nc nc nc nc nc nc
10th Edition
nc
,Table of Contents
nc nc
Chapter 01 Properties and Overview of Immune Responses
nc nc nc nc nc nc nc 1
Chapter 02 Cells and Tissues of the Immune System
nc nc nc nc nc nc nc nc 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
nc nc nc nc nc nc nc 6
Chapter 04 Innate Immunity
nc nc nc 10
Chapter 05 Antibodies and Antigens
nc nc nc nc 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
nc nc nc nc nc nc nc nc nc nc nc
Histocompatibility Complex Molecules
nc nc 20
Chapter 07 Immune Receptors and Signal Transduction
nc nc nc nc nc nc 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
nc nc nc nc nc nc nc nc 30
Chapter 09 Activation of T Lymphocytes
nc nc nc nc nc 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
nc nc nc nc nc nc nc nc nc 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
nc nc nc nc nc nc nc nc nc 42
Chapter 12 B Cell Activation and Antibody Production
nc nc nc nc nc nc nc 46
Chapter 13 Effector Mechanisms of Humoral Immunity
nc nc nc nc nc nc 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
nc nc nc nc nc nc nc nc nc nc nc 56
Chapter 15 Immunologic Tolerance and Autoimmunity
nc nc nc nc nc 62
Chapter 16 Immunity to Microbes
nc nc nc nc 67
Chapter 17 Transplantation Immunology
nc nc nc 72
Chapter 18 Tumor Immunology
nc nc nc 77
Chapter 19 Hypersensitivity Disorders
nc nc nc 81
Chapter 20 Allergy
nc nc 86
Chapter 21 Primary and Acquired Immunodeficiencies
nc nc nc nc nc 89
,Chapter 01: Properties and Overview of Immune Responses
nc nc nc nc nc nc nc
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
nc nc nc nc nc nc nc nc nc
MULTIPLE CHOICE nc
1. The principal function of the immune system is:
nc nc nc nc nc nc nc
a. Defense against cancer nc nc
b. Repair of injured tissues nc nc nc
c. Defense against microbial infections nc nc nc
d. Prevention of inflammatory diseases nc nc nc
e. Protection against environmental toxins nc nc nc
ANS: C n c
The immune system has evolved in the setting of selective pressures imposed by microbia
nc nc nc nc nc nc nc nc nc nc nc nc nc
l infections. Although immune responses to cancer may occur, the concept that ―immuno
nc nc nc nc nc nc nc nc nc nc nc nc
surveillance‖ against cancer is a principal function of the immune system is controversial
nc nc nc nc nc nc nc nc nc nc nc nc
. Repair of injured tissues may be a secondary consequence of the immune responses and
nc nc nc nc nc nc nc nc nc nc nc nc nc nc
inflammation. Although the immune system has regulatory features that are needed to pr
nc nc nc nc nc nc nc nc nc nc nc nc nc
event excessive inflammation, prevention of inflammatory diseases is not a primary funct
nc nc nc nc nc nc nc nc nc nc nc
ion. The immune system can protect against microbial toxins, but it generally does not off
nc nc nc nc nc nc nc nc nc nc nc nc nc nc
er protection against toxins of nonbiologic origin.
nc nc nc nc nc nc
2. Which of the following infectious diseases was prevented by the first successfu
nc nc nc nc nc nc nc nc nc nc nc
l vaccination?
nc
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C n c
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
nc nc nc nc nc nc nc nc nc nc nc nc
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
nc nc nc nc nc nc nc nc nc nc nc nc nc nc nc
smallpox was reported to be eradicated worldwide by a vaccination program. Effective v
nc nc nc nc nc nc nc nc nc nc nc nc nc
accines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th ce
nc nc nc nc nc nc nc nc nc nc nc nc nc
ntury and are widely used. There is no effective vaccine against Mycobacterium tubercul
nc nc nc nc nc nc nc nc nc nc nc nc
osis.
3. Which of the following is a unique property of the adaptive immune system?
nc nc nc nc nc nc nc nc nc nc nc nc
a. Highly diverse repertoire of specificities for antigens
nc nc nc nc nc nc
b. Self-nonself discrimination nc
c. Recognition of microbial structures by both cell-associated and soluble receptors
nc nc nc nc nc nc nc nc nc
d. Protection against viral infections nc nc nc
e. Responses that have the same kinetics and magnitude on repeated exposure to th
nc nc nc nc nc nc nc nc nc nc nc nc
e same microbe nc nc
ANS: n c A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
nc nc nc nc nc nc nc nc nc nc nc nc nc nc
cytes, which are the central cellular components of the adaptive immune system. Both th
nc nc nc nc nc nc nc nc nc nc nc nc nc
e innate and the adaptive immune systems use cell-
nc nc nc nc nc nc nc nc
associated and soluble receptors to recognize microbes, display some degree of self-
nc nc nc nc nc nc nc nc nc nc nc
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
nc nc nc nc nc nc nc nc nc nc nc nc
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
nc nc nc nc nc nc nc nc nc nc nc nc nc
s the manifestation of memory.
nc nc nc nc
4. Antibodies and T lymphocytes are the respective mediators of which two types o
nc nc nc nc nc nc nc nc nc nc nc nc
f immunity?
nc
a. Innate and adaptive nc nc
b. Passive and active nc nc
c. Specific and nonspecific nc nc
d. Humoral and cell-mediated nc nc
e. Adult and neonatal nc nc
ANS: D n c
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
nc nc nc nc nc nc nc nc nc nc nc nc
s produce antibodies, which are the recognition and effector molecules of humoral immun
nc nc nc nc nc nc nc nc nc nc nc nc
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
nc nc nc nc nc nc nc nc nc nc nc nc
ellular pathogens in cell-
nc nc nc
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
nc nc nc nc nc nc nc nc nc nc nc nc nc nc nc
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
nc nc nc nc nc nc nc nc nc nc nc nc nc
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
nc nc nc nc nc nc nc nc nc nc nc nc nc
d.
5. The two major functional classes of effector T lymphocytes are:
nc nc nc nc nc nc nc nc nc
a. Helper T lymphocytes and cytotoxic T lymphocytes
nc nc nc nc nc nc
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
nc nc nc nc
c. Memory T cells and effector T cells nc nc nc nc nc nc
d. Helper cells and antigen-presenting cells nc nc nc nc
e. Cytotoxic T lymphocytes and target cells nc nc nc nc nc
ANS: A n c
T cells can be classified into effector subsets that perform different effector functions. Mos
nc nc nc nc nc nc nc nc nc nc nc nc nc
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
nc nc nc nc nc nc nc nc nc nc nc nc nc nc nc
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
nc nc nc nc nc nc nc nc nc nc nc nc
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
nc nc nc nc nc nc nc nc nc nc nc nc
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. nc nc nc nc nc nc nc nc nc nc nc nc nc nc
6. Which of the following cell types is required for all adaptive humoral immune responses?
nc nc nc nc nc nc nc nc nc nc nc nc nc
a. Natural killer cells nc nc
b. Dendritic cells nc
c. Cytolytic T lymphocytes nc nc
d. B lymphocytes nc
e. Helper T lymphocytes nc nc
ANS: D n c
Humoral immune responses are antibody- nc nc nc nc
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
nc nc nc nc nc nc nc nc nc nc nc nc nc
er cell type.
nc nc
Cellular and Molecular Immunology
nc nc nc
Abul Abbas, Andrew Lichtman, and Shiv Pillai
nc nc nc nc nc nc
10th Edition
nc
,Table of Contents
nc nc
Chapter 01 Properties and Overview of Immune Responses
nc nc nc nc nc nc nc 1
Chapter 02 Cells and Tissues of the Immune System
nc nc nc nc nc nc nc nc 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
nc nc nc nc nc nc nc 6
Chapter 04 Innate Immunity
nc nc nc 10
Chapter 05 Antibodies and Antigens
nc nc nc nc 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
nc nc nc nc nc nc nc nc nc nc nc
Histocompatibility Complex Molecules
nc nc 20
Chapter 07 Immune Receptors and Signal Transduction
nc nc nc nc nc nc 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
nc nc nc nc nc nc nc nc 30
Chapter 09 Activation of T Lymphocytes
nc nc nc nc nc 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
nc nc nc nc nc nc nc nc nc 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
nc nc nc nc nc nc nc nc nc 42
Chapter 12 B Cell Activation and Antibody Production
nc nc nc nc nc nc nc 46
Chapter 13 Effector Mechanisms of Humoral Immunity
nc nc nc nc nc nc 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
nc nc nc nc nc nc nc nc nc nc nc 56
Chapter 15 Immunologic Tolerance and Autoimmunity
nc nc nc nc nc 62
Chapter 16 Immunity to Microbes
nc nc nc nc 67
Chapter 17 Transplantation Immunology
nc nc nc 72
Chapter 18 Tumor Immunology
nc nc nc 77
Chapter 19 Hypersensitivity Disorders
nc nc nc 81
Chapter 20 Allergy
nc nc 86
Chapter 21 Primary and Acquired Immunodeficiencies
nc nc nc nc nc 89
,Chapter 01: Properties and Overview of Immune Responses
nc nc nc nc nc nc nc
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
nc nc nc nc nc nc nc nc nc
MULTIPLE CHOICE nc
1. The principal function of the immune system is:
nc nc nc nc nc nc nc
a. Defense against cancer nc nc
b. Repair of injured tissues nc nc nc
c. Defense against microbial infections nc nc nc
d. Prevention of inflammatory diseases nc nc nc
e. Protection against environmental toxins nc nc nc
ANS: C n c
The immune system has evolved in the setting of selective pressures imposed by microbia
nc nc nc nc nc nc nc nc nc nc nc nc nc
l infections. Although immune responses to cancer may occur, the concept that ―immuno
nc nc nc nc nc nc nc nc nc nc nc nc
surveillance‖ against cancer is a principal function of the immune system is controversial
nc nc nc nc nc nc nc nc nc nc nc nc
. Repair of injured tissues may be a secondary consequence of the immune responses and
nc nc nc nc nc nc nc nc nc nc nc nc nc nc
inflammation. Although the immune system has regulatory features that are needed to pr
nc nc nc nc nc nc nc nc nc nc nc nc nc
event excessive inflammation, prevention of inflammatory diseases is not a primary funct
nc nc nc nc nc nc nc nc nc nc nc
ion. The immune system can protect against microbial toxins, but it generally does not off
nc nc nc nc nc nc nc nc nc nc nc nc nc nc
er protection against toxins of nonbiologic origin.
nc nc nc nc nc nc
2. Which of the following infectious diseases was prevented by the first successfu
nc nc nc nc nc nc nc nc nc nc nc
l vaccination?
nc
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C n c
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
nc nc nc nc nc nc nc nc nc nc nc nc
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
nc nc nc nc nc nc nc nc nc nc nc nc nc nc nc
smallpox was reported to be eradicated worldwide by a vaccination program. Effective v
nc nc nc nc nc nc nc nc nc nc nc nc nc
accines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th ce
nc nc nc nc nc nc nc nc nc nc nc nc nc
ntury and are widely used. There is no effective vaccine against Mycobacterium tubercul
nc nc nc nc nc nc nc nc nc nc nc nc
osis.
3. Which of the following is a unique property of the adaptive immune system?
nc nc nc nc nc nc nc nc nc nc nc nc
a. Highly diverse repertoire of specificities for antigens
nc nc nc nc nc nc
b. Self-nonself discrimination nc
c. Recognition of microbial structures by both cell-associated and soluble receptors
nc nc nc nc nc nc nc nc nc
d. Protection against viral infections nc nc nc
e. Responses that have the same kinetics and magnitude on repeated exposure to th
nc nc nc nc nc nc nc nc nc nc nc nc
e same microbe nc nc
ANS: n c A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
nc nc nc nc nc nc nc nc nc nc nc nc nc nc
cytes, which are the central cellular components of the adaptive immune system. Both th
nc nc nc nc nc nc nc nc nc nc nc nc nc
e innate and the adaptive immune systems use cell-
nc nc nc nc nc nc nc nc
associated and soluble receptors to recognize microbes, display some degree of self-
nc nc nc nc nc nc nc nc nc nc nc
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
nc nc nc nc nc nc nc nc nc nc nc nc
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
nc nc nc nc nc nc nc nc nc nc nc nc nc
s the manifestation of memory.
nc nc nc nc
4. Antibodies and T lymphocytes are the respective mediators of which two types o
nc nc nc nc nc nc nc nc nc nc nc nc
f immunity?
nc
a. Innate and adaptive nc nc
b. Passive and active nc nc
c. Specific and nonspecific nc nc
d. Humoral and cell-mediated nc nc
e. Adult and neonatal nc nc
ANS: D n c
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
nc nc nc nc nc nc nc nc nc nc nc nc
s produce antibodies, which are the recognition and effector molecules of humoral immun
nc nc nc nc nc nc nc nc nc nc nc nc
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
nc nc nc nc nc nc nc nc nc nc nc nc
ellular pathogens in cell-
nc nc nc
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
nc nc nc nc nc nc nc nc nc nc nc nc nc nc nc
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
nc nc nc nc nc nc nc nc nc nc nc nc nc
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
nc nc nc nc nc nc nc nc nc nc nc nc nc
d.
5. The two major functional classes of effector T lymphocytes are:
nc nc nc nc nc nc nc nc nc
a. Helper T lymphocytes and cytotoxic T lymphocytes
nc nc nc nc nc nc
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
nc nc nc nc
c. Memory T cells and effector T cells nc nc nc nc nc nc
d. Helper cells and antigen-presenting cells nc nc nc nc
e. Cytotoxic T lymphocytes and target cells nc nc nc nc nc
ANS: A n c
T cells can be classified into effector subsets that perform different effector functions. Mos
nc nc nc nc nc nc nc nc nc nc nc nc nc
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
nc nc nc nc nc nc nc nc nc nc nc nc nc nc nc
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
nc nc nc nc nc nc nc nc nc nc nc nc
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
nc nc nc nc nc nc nc nc nc nc nc nc
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. nc nc nc nc nc nc nc nc nc nc nc nc nc nc
6. Which of the following cell types is required for all adaptive humoral immune responses?
nc nc nc nc nc nc nc nc nc nc nc nc nc
a. Natural killer cells nc nc
b. Dendritic cells nc
c. Cytolytic T lymphocytes nc nc
d. B lymphocytes nc
e. Helper T lymphocytes nc nc
ANS: D n c
Humoral immune responses are antibody- nc nc nc nc
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
nc nc nc nc nc nc nc nc nc nc nc nc nc
er cell type.
nc nc
