Test Bank - Cellular and Molecular Immunology, 10th Edition (Abbas, 2022), Chapter 1-21 | All Chapters

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Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10thEdition
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Chapter2:CellsandTissuesoftheImmuneSystemMatching
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Questions1-5
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Matcheachofthedescriptionsin questions1-5withtheappropriatename(A-M) of an anatomicf eature of
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l ymphoidt issues.
b V b V b




A. Periarteriolarl ymphoidsheath V b V




B. Thymicmedulla
C. Thymiccortex
D. Parafollicularcortexofl ymphnode V V V b V




E. Hematopoieticbonemarrow V V




F. Afferentlymphatic
G. Efferentlymphatic
H. Marginalzone
I. Redpulpofspleen
J. Whitepulpofspleen
K. Epidermis
L. Dermis
M. Peyer’spatch

1. LocationofmostTlymphocytesi nthespleen
V V b




ANS:A.Theperiarteriolarlymphoidsheathsurroundsthecentralarteriesinthespleenand istheT cell zone V Vb Vb




i nt hisorgan.
b V b V b V




2. Vesselsthatdrain lymphawayfroma lymphnode v b v V




ANS:G.Efferentl ymphaticvesselsdrainlymphawayfroml V V b V V V V V V




ymphnodes;afferentvesselsdrain l ymphi ntol ymphnodes.
b V V V V b V b V b V b V




3. Siteofl eastmatureTcellprecursorsi nt hethymus
V b V b V b




ANS: C.Bonemarrow–derivedTcell precursors first entert he thymiccortex and migrate
V
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b b V bV b V
b b




i ntothe medulla ast heybecomemoremature.
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4. LocationofLangerhanscells V V




ANS:K.Langerhanscellsaredendriticcellsi nt heepidermisoft heskint hatdevelopf romf
V V V V V V b V b V V V b V V b V V b V




etalmacrophages.
b V




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5. Lymphoidaggregateofthemucosalimmunesystem b V v V b




ANS: M. Peyer’s patches are B cell–rich lymphoid aggregates located in the submucosa of the
bV bV bV bV bV bV bV bV bV bV bVb bV bV bV




smallintestine.
bV




MultipleChoice V




6. Whichofthef ollowingi st hegenerative( primary)l ymphoidorganforTlymphocytes? V b V b V b V V b V b V b




A. Bonemarrow
B. Spleen
C. Lymphnode
D. Thymus
E. Tonsil


ANS: D. Generative (primary) lymphoid organs are the organs where lymphocytes first express
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antigen receptors and attain functional maturity. Although T cell precursors arise in the bone marrow,
bV V b V b V b V V V V V b V V b V V V V




these precursors migratet o the thymus, where maturation takes place. In contrast, B cells mature in the
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bone marrow. Spleen, lymph node, and tonsil are secondary lymphoid organs populated by mature B
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andTcells.
bV V




7. Whichoft hef ollowingstatementsaboutt issue-residentmacrophagesi scorrect?
V V b V b V V V b V V b V




A. Theyareallderivedf rombloodmonocytesthatentert issuesduringinfections V V b V V V b V




B. Manyofthesecellsf irstpopulatetissuesduringfetaldevelopment V V V b V V V




C. Theydifferentiatefromdifferentkindsofepithelialcellsi n eacht issue V b b V V b V b V V b




D. Theyconstantlyr ecirculatebetweendifferentt issues V V b V V V b




E. Theyareprofessionalantigen-presenting cellsthatactivatenaiveTcells thatmigrateinto V b b b




tissues
V




ANS: B. Many tissue-resident macrophages are derived from fetal yolk sac and fetal liver precursors and
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establish residence in the different tissues during fetal development. Other tissue- r esident
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macrophages are derived from bone marrow–derived blood monocytes that enter tissues under
bV bV b bV bV bV bV bV bV bV bV bV bV




normal conditions or during infections. Epithelial cells do not differentiate into macrophages. Once in
bV V b V V V V V V V V V V V V




the tissue, tissue-resident macrophages cells do not leave to recirculate. Naive T cells do not usually enter
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non-lymphoid tissues, and tissue-resident macrophages have no r ole i n presenting antigen t o
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b bV b V b




naiveTcells.
bV V V




8. Which typeofleukocytei st he mostabundanti nt hebloodof ahealthyadult? V V b V b V V b V b b v V




A. Monocytes
B. Blymphocytes
C. Tlymphocytes
D. Polymorphonuclearleukocytes V




E. Basophils




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ANS: D. Polymorphonuclear leukocytes (or neutrophils) are t he most abundant blood leukocyte (~
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b bV b V b V
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4,000/mm),3 aboutt wicet he number of B and Tl ymphocytescombined.
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9. Whichofthef ollowingi safeatureoff ibroblasticr eticularcells( FRCs)?
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A. Theylinethelumensoflymphaticsenteringl ymphnodes V V V b




B. Theyarederivedf romhematopoieticprecursors V b V V




C. Theyplayacriticalr olei nestablishingwherelymphocytesarelocatedi nl ymphnodes V V V b V b V V V V b V b V




D. Theysecretecytokinest hatstimulateTcellproliferation V b V V




E. Theyarephagocyticcellsofi nnateimmunitythatkillmicrobes V V V b V




ANS: C. FRCs are mesenchymal-derived (not haematopoietically-derived) cells with properties of
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muscle and fibroblast (myofibroblasts) that drive formation of secondary lymphoid organs during
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embryonic development and contributet
bV o the anatomic segregation and movement ofl
V V V V b V V V V V V V




ymphocytesand dendritic cells in secondary lymphoid organs. They are not phagocytic, have no direct
b V bV bV bV bV bV bV bV bV bV bV bV bV bV




antimicrobial
bV effectorfunctions,donotsecrete IL-2orotherTcellgrowth factors, and donotlinel bV V V V V V V V V V V V V V V V V




umens ofl ymphatics.
b V V b




10. Which type of cell is most important in capturing protein antigens of
Vb bV b bV b bV b bV b bV b bV b bV b bV b bV b bV b bV




microbes thatenterthroughepithelialbarriersandpresentingt hemt onaiveTcellsi nsecondaryl
b bV V V V V V V b V b V V b V V




ymphoid organs?
b bV




A. Classicaldendriticcells V V




B. Plasmacytoid dendriticcells V V




C. Plasmacells
D. Macrophages
E. Folliculardendriticcells V




ANS: A. Classical (or conventional) dendritic cells (DCs) are the main cell type that brings microbial
bV bV bV V bV bV bV bV V bV bV bV bV bV bV




antigens from infected tissues into draining lymph nodes and presents peptides derived f rom these
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antigens to naive T cells that circulate though the lymph nodes. Plasmacytoid DCs secrete type 1
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interferons in response to
bV viral infection. Plasma cells are antibody-secreting cells derived from B cells
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and do not present antigen to T cells. Macrophages can present antigen to effector T cells, but they are
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not efficient activators of
bV V naive T cells. Follicular dendritic cells displayantigenst V o B cells onl V V b V V V V V V V V b V V V V




ymphoid f ollicles.
b b V b




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