TESTBANK
CellularandMolecularImmunology
h
AbulAbbas,AndrewLichtman,andShiv Pillai
h
10thEdition
,TableofContents
Chapter01PropertiesandOverviewofImmuneResponses 1
Chapter02CellsandTissuesoftheImmuneSystem 3
Chapter03 LeukocyteCirculation andMigration IntoTissues
hh hh hh 6
Chapter04Innate Immunity
hh 10
Chapter05AntibodiesandAntigens 17
Chapter06AntigenPresentationtoTLymphocytesandtheFunctionsof Major
h h h h h
HistocompatibilityComplex Molecules hh 20
Chapter07 ImmuneReceptors and SignalTransduction b 27
Chapter08LymphocyteDevelopmentandAntigenReceptorGeneRearrangement
h h h h h h 30
Chapter09ActivationofT Lymphocytes hh 34
Chapter10 Differentiation andFunctionsofCD4+EffectorTCells
hh hh 38
Chapter11 Differentiation andFunctionsofCD8+EffectorTCells
hh hh 42
Chapter12 BCell Activation and AntibodyProduction
hh hh hh hh 46
Chapter13EffectorMechanismsofHumoral Immunity hh 52
Chapter14Specialized Immunityat EpithelialBarriersandin ImmunePrivileged Tissues
hh hh hh hh 56
Chapter15 Immunologic Toleranceand Autoimmunity
b 62
Chapter16 Immunityto Microbes
hh hh 67
Chapter17Transplantation Immunology hh 72
Chapter18 Tumor Immunology
hh hh 77
Chapter19 HypersensitivityDisorders
hh 81
Chapter20 Allergy
hh 86
Chapter21Primaryand Acquired Immunodeficiencies
hh h h 89
,Chapter01:PropertiesandOverviewofImmuneResponses b b
Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10thEdition
hh b
MULTIPLECHOICE
1. Theprincipalfunctionoftheimmunesystem is: b
a. Defenseagainstcancer
b. Repairofinjured tissues b
c. Defenseagainstmicrobialinfections b
d. Preventionofinflammatorydiseases
e. Protectionagainstenvironmentaltoxins
ANS: C h h h h
Theimmunesystemhasevolvedinthesettingofselectivepressuresimposedbymicrobial h
infections. Although immune responses to cancer may occur, the concept that
h h hh hh hh hh hh hh hh hh hh hh
“immunosurveillance” against cancer is a principal function of the immune system is
hh hh hh hh hh hh hh hh hh hh hh hh
controversial. Repair of injured tissues may be a secondary consequence of the immune
hh hh hh hh hh hh hh hh hh hh hh hh hh
responses and inflammation. Although theimmunesystem has regulatoryfeatures that are
hh hh hh hh hh hh hh hh hh
needed to prevent excessive inflammation, prevention of inflammatory diseases is nota
hh hh hh hh hh hh hh hh hh hh hh
primaryfunction.The immune system can protect againstmicrobialtoxins,butitgenerally does
hh b b h b hh hh
not offer protection against toxinsof nonbiologic origin.
hh hh hh hh hh hh hh
2. Whichofthefollowinginfectiousdiseaseswaspreventedbythefirstsuccessful
vaccination?
h h
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C h h h h
In1798,EdwardJennerreportedthefirstintentionalsuccessfulvaccination,whichwasagainst
h h h h h h h h h h h
smallpoxinaboy,usingmaterialfromthecowpoxpustulesofamilkmaid. In 1980, smallpox
hh hh hh hh
was reported tobe eradicated worldwide by avaccination program. Effective vaccines against
h h h h h h h h h h h hh h h
tetanus toxin, rubella virus, and poliovirusweredeveloped in the 20thcentury and
hh hh hh hh hh hh hh hh hh hh
arewidely used. There is no effective vaccine against Mycobacteriumtuberculosis.
hh hh hh hh hh hh hh hh hh
3. Whichofthefollowingisauniquepropertyoftheadaptiveimmunesystem? b
a. Highlydiverserepertoireofspecificities forantigens b
b. Self-nonselfdiscrimination
c. Recognitionof microbialstructuresbybothcell-associatedand solublereceptors
b b
d. Protectionagainstviralinfections b
e. Responsesthathavethesamekineticsandmagnitudeonrepeatedexposuretothe h h
samemicrobe h h h
ANS: h h h h A
, Highly diverse repertoires of specificities forantigens arefound only inT and Blymphocytes,
h h hh h h h hh hh h h h
which arethe central cellular components of the adaptive immune system. Boththeinnateand
hh hh hh hh hh hh hh hh hh hh hh
theadaptive immunesystems usecell-associatedandsolublereceptors to recognize microbes,
hh b b hh hh hh
display some degree of self-nonself discrimination, and protect againstviruses. On repeated
hh hh hh hh hh hh hh hh hh hh hh
exposuretothesamemicrobe, theadaptiveimmuneresponse becomes more rapid and of
hh hh hh hh hh hh hh
greater magnitude; this isthe manifestation of memory.
hh hh hh hh hh hh hh
4. Antibodiesand Tlymphocytesaretherespectivemediators ofwhichtwotypesof
b b h h
h immunity?
h
a. Innateandadaptive
b. Passiveandactive
c. Specificand nonspecific b
d. Humoralandcell-mediated
e. Adultandneonatal
ANS: D h h h h
Both Band Tlymphocytes areprincipal components of adaptive immunity. Blymphocytes
hh hh hh hh hh hh hh hh
produce antibodies, which arethe recognition and effector molecules of humoral immune
hh hh hh hh hh hh hh hh hh hh hh
responsesto extracellularpathogens. T cellsrecognizeand promote eradication ofintracellular
hh h h h h h h h h h h h
pathogensincell-mediatedimmunity. Passiveandactiveimmunityboth can be mediated by
hh hh hh h hh hh
either B or Tlymphocytes. Specificimmunity is another term for adaptive immunity. Both Band T
hh h hh h hh hh h hh hh h h hh h hh
lymphocytesparticipate in adult adaptive immunity but are still developing in the neonatal
hh hh hh hh hh hh hh hh hh hh hh hh
period.
hh
5. Thetwomajorfunctional classesofeffectorTlymphocytesare: b
a. HelperTlymphocytesand cytotoxicTlymphocytes b
b. NaturalkillercellsandcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryTcellsandeffectorTcells
d. Helpercellsandantigen-presentingcells
e. CytotoxicTlymphocytes and target cells b b b
ANS: A h h h h
Tcellscanbeclassifiedintoeffectorsubsetsthatperformdifferenteffectorfunctions.Most
h h
effectorTcellsareeither helperTlymphocytes,whichenhancetheresponses ofotherimmune
hh h h h h h h h h h h h h h
cells, including phagocytes and Bcells, toinfections, or cytotoxic Tlymphocytes, which
hh hh hh hh hh hh hh hh hh hh
directly kill infected cells. Natural killer cells arenot T lymphocytes.
hh hh hh hh hh hh hh hh hh hh
Antigen-presentingcellsusuallyarenotTcells.MemoryTcellsarenot effectorTcells. b b
6. Whichofthefollowingcelltypesisrequiredforalladaptivehumoralimmuneresponses? b
a. Naturalkillercells
b. Dendritic cells hh
c. CytolyticTlymphocytes
d. Blymphocytes
e. HelperTlymphocytes
ANS: D h h h h
Humoralimmuneresponses areantibody-mediated immuneresponses,andallantibodiesare b b h
madeby Blymphocytes and no other cell type.
hh hh hh hh hh hh hh
CellularandMolecularImmunology
h
AbulAbbas,AndrewLichtman,andShiv Pillai
h
10thEdition
,TableofContents
Chapter01PropertiesandOverviewofImmuneResponses 1
Chapter02CellsandTissuesoftheImmuneSystem 3
Chapter03 LeukocyteCirculation andMigration IntoTissues
hh hh hh 6
Chapter04Innate Immunity
hh 10
Chapter05AntibodiesandAntigens 17
Chapter06AntigenPresentationtoTLymphocytesandtheFunctionsof Major
h h h h h
HistocompatibilityComplex Molecules hh 20
Chapter07 ImmuneReceptors and SignalTransduction b 27
Chapter08LymphocyteDevelopmentandAntigenReceptorGeneRearrangement
h h h h h h 30
Chapter09ActivationofT Lymphocytes hh 34
Chapter10 Differentiation andFunctionsofCD4+EffectorTCells
hh hh 38
Chapter11 Differentiation andFunctionsofCD8+EffectorTCells
hh hh 42
Chapter12 BCell Activation and AntibodyProduction
hh hh hh hh 46
Chapter13EffectorMechanismsofHumoral Immunity hh 52
Chapter14Specialized Immunityat EpithelialBarriersandin ImmunePrivileged Tissues
hh hh hh hh 56
Chapter15 Immunologic Toleranceand Autoimmunity
b 62
Chapter16 Immunityto Microbes
hh hh 67
Chapter17Transplantation Immunology hh 72
Chapter18 Tumor Immunology
hh hh 77
Chapter19 HypersensitivityDisorders
hh 81
Chapter20 Allergy
hh 86
Chapter21Primaryand Acquired Immunodeficiencies
hh h h 89
,Chapter01:PropertiesandOverviewofImmuneResponses b b
Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10thEdition
hh b
MULTIPLECHOICE
1. Theprincipalfunctionoftheimmunesystem is: b
a. Defenseagainstcancer
b. Repairofinjured tissues b
c. Defenseagainstmicrobialinfections b
d. Preventionofinflammatorydiseases
e. Protectionagainstenvironmentaltoxins
ANS: C h h h h
Theimmunesystemhasevolvedinthesettingofselectivepressuresimposedbymicrobial h
infections. Although immune responses to cancer may occur, the concept that
h h hh hh hh hh hh hh hh hh hh hh
“immunosurveillance” against cancer is a principal function of the immune system is
hh hh hh hh hh hh hh hh hh hh hh hh
controversial. Repair of injured tissues may be a secondary consequence of the immune
hh hh hh hh hh hh hh hh hh hh hh hh hh
responses and inflammation. Although theimmunesystem has regulatoryfeatures that are
hh hh hh hh hh hh hh hh hh
needed to prevent excessive inflammation, prevention of inflammatory diseases is nota
hh hh hh hh hh hh hh hh hh hh hh
primaryfunction.The immune system can protect againstmicrobialtoxins,butitgenerally does
hh b b h b hh hh
not offer protection against toxinsof nonbiologic origin.
hh hh hh hh hh hh hh
2. Whichofthefollowinginfectiousdiseaseswaspreventedbythefirstsuccessful
vaccination?
h h
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C h h h h
In1798,EdwardJennerreportedthefirstintentionalsuccessfulvaccination,whichwasagainst
h h h h h h h h h h h
smallpoxinaboy,usingmaterialfromthecowpoxpustulesofamilkmaid. In 1980, smallpox
hh hh hh hh
was reported tobe eradicated worldwide by avaccination program. Effective vaccines against
h h h h h h h h h h h hh h h
tetanus toxin, rubella virus, and poliovirusweredeveloped in the 20thcentury and
hh hh hh hh hh hh hh hh hh hh
arewidely used. There is no effective vaccine against Mycobacteriumtuberculosis.
hh hh hh hh hh hh hh hh hh
3. Whichofthefollowingisauniquepropertyoftheadaptiveimmunesystem? b
a. Highlydiverserepertoireofspecificities forantigens b
b. Self-nonselfdiscrimination
c. Recognitionof microbialstructuresbybothcell-associatedand solublereceptors
b b
d. Protectionagainstviralinfections b
e. Responsesthathavethesamekineticsandmagnitudeonrepeatedexposuretothe h h
samemicrobe h h h
ANS: h h h h A
, Highly diverse repertoires of specificities forantigens arefound only inT and Blymphocytes,
h h hh h h h hh hh h h h
which arethe central cellular components of the adaptive immune system. Boththeinnateand
hh hh hh hh hh hh hh hh hh hh hh
theadaptive immunesystems usecell-associatedandsolublereceptors to recognize microbes,
hh b b hh hh hh
display some degree of self-nonself discrimination, and protect againstviruses. On repeated
hh hh hh hh hh hh hh hh hh hh hh
exposuretothesamemicrobe, theadaptiveimmuneresponse becomes more rapid and of
hh hh hh hh hh hh hh
greater magnitude; this isthe manifestation of memory.
hh hh hh hh hh hh hh
4. Antibodiesand Tlymphocytesaretherespectivemediators ofwhichtwotypesof
b b h h
h immunity?
h
a. Innateandadaptive
b. Passiveandactive
c. Specificand nonspecific b
d. Humoralandcell-mediated
e. Adultandneonatal
ANS: D h h h h
Both Band Tlymphocytes areprincipal components of adaptive immunity. Blymphocytes
hh hh hh hh hh hh hh hh
produce antibodies, which arethe recognition and effector molecules of humoral immune
hh hh hh hh hh hh hh hh hh hh hh
responsesto extracellularpathogens. T cellsrecognizeand promote eradication ofintracellular
hh h h h h h h h h h h h
pathogensincell-mediatedimmunity. Passiveandactiveimmunityboth can be mediated by
hh hh hh h hh hh
either B or Tlymphocytes. Specificimmunity is another term for adaptive immunity. Both Band T
hh h hh h hh hh h hh hh h h hh h hh
lymphocytesparticipate in adult adaptive immunity but are still developing in the neonatal
hh hh hh hh hh hh hh hh hh hh hh hh
period.
hh
5. Thetwomajorfunctional classesofeffectorTlymphocytesare: b
a. HelperTlymphocytesand cytotoxicTlymphocytes b
b. NaturalkillercellsandcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryTcellsandeffectorTcells
d. Helpercellsandantigen-presentingcells
e. CytotoxicTlymphocytes and target cells b b b
ANS: A h h h h
Tcellscanbeclassifiedintoeffectorsubsetsthatperformdifferenteffectorfunctions.Most
h h
effectorTcellsareeither helperTlymphocytes,whichenhancetheresponses ofotherimmune
hh h h h h h h h h h h h h h
cells, including phagocytes and Bcells, toinfections, or cytotoxic Tlymphocytes, which
hh hh hh hh hh hh hh hh hh hh
directly kill infected cells. Natural killer cells arenot T lymphocytes.
hh hh hh hh hh hh hh hh hh hh
Antigen-presentingcellsusuallyarenotTcells.MemoryTcellsarenot effectorTcells. b b
6. Whichofthefollowingcelltypesisrequiredforalladaptivehumoralimmuneresponses? b
a. Naturalkillercells
b. Dendritic cells hh
c. CytolyticTlymphocytes
d. Blymphocytes
e. HelperTlymphocytes
ANS: D h h h h
Humoralimmuneresponses areantibody-mediated immuneresponses,andallantibodiesare b b h
madeby Blymphocytes and no other cell type.
hh hh hh hh hh hh hh
