BLOOD PHYSIOLOGY
By:-
Dr. Ali Zain
MBBS, RMP
FCPS PGR
PHYSIOLOGY DEP.
, The Rawalpindi Medical University
LEARNING OBJECTIVES
At the end of the discussion, students will be able:
• To discuss briefly composition of blood.
• To understand the concept of structure of RBCs.
• To differentiate the structure of haemoglobin types.
• To discuss all phases of Erythropoiesis and role of different
factors affecting it.
• To have complete concept of IRON METABOLISM.
, The Rawalpindi Medical University
Introduction:-
BLOOD
BLOOD CELLS 45% BLOOD PLASMA 55%.
(RBCs, WBCs, Platelets) (water, proteins, nitrates, gases, ions, wastes)
FUNCTIONS OF BLOOD Coagulation factors
Nutritive function Antibodies
Albumin
Respiratory function
Fibrinogen
Excretory function PLASMA – FIBRINOGEN = SERUM
Transport
Water balance
Acid base balance
Storage
Immunity
Regulation of body temperature
, The Rawalpindi Medical University
RED BLOOD CELLs:-
Biconcove (membrane> material)
CO2 Transport Oxygen Transport Acid base buffer
Carbonic anhydrase (haemoglobin)
enzyme
100ml blood à 45ml RBCs
100ml RBCs. à 34g
hemoglobin
100ml blood. à 15g
hemoglobin
1gm Hb. à 1.34ml
oxygen
100ml Blood à 20ml
oxygen