CEN TOXICOLOGY 2025/2026 EXAM
QUESTIONS AND ANSWERS | 100%
PASS
Anticholinergics [not producing fluids/blood to heart, lungs and brain] syndrome
(antihistamines, bronchodilators, cyclic antidepressants, SLEEP AIDS) -
🧠ANSWER ✔✔Hot as a hare (hyperthermia)
Red as a beet (flushed)
Dry as a bone [ANHYDROSIS (dry skin, urinary retention)
Blind as a bat (mydriasis)
Mad as a hatter (hallucinations, delirium, myoclonic jerking)
The antidote for anticholinergic toxicity is physostigmine salicylate. Physostigmine
is the only reversible acetylcholinesterase inhibitor capable of directly
antagonizing the CNS manifestations of anticholinergic toxicity; it is an uncharged
tertiary amine that efficiently crosses the blood-brain barrier
,What does muscular rigidity cause - 🧠ANSWER ✔✔rhabdomylosis syndrome due
to a direct or indirect muscle injury. It results from the death of muscle fibers and
release of their contents into the bloodstream (myoglobin). This can lead to renal
(kidney) failure.
sympathomimetic [fight or flight/shunt blood going to heart/brain/lungs] -
🧠ANSWER ✔✔MIMIC SYMPATHETIC
a drug that stimulates the sympathetic branch of the autonomic nervous system
Epinephrine, adrenaline
Organophosphate poisoning
Cholinergics {see, spit, pee, shit] used in pesticides b/c - 🧠ANSWER ✔✔BUGS
DROWN with Cholinergic [producing fluids: saliva, urine, digestive enzymes]
Organophosphates are used as insecticides, medications, and nerve agents.
Symptoms include increased saliva and tear production, diarrhea, vomiting, small
pupils, sweating, muscle tremors, and confusion.
Cholinergics {see, spit, pee, shit] pathway - 🧠ANSWER ✔✔muscuric and
nicotinic receptors that use acetylcholine neurotransmitters
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
2
STATEMENT. ALL RIGHTS RESERVED
, cholinergic cells that use which neurotransmitter - 🧠ANSWER ✔✔Referring to
cells that use acetylcholine as their synaptic transmitter.
SLUDGE-bbb - 🧠ANSWER ✔✔Muscarinic Cholinergic syndrome
Salvation
lacrimination
urination
defecation
gastric emesis
bronchoria
bronchospasm
bradycardia
miosis
increased bowel sounds
Cholinergic Drug toxicity
antidote - 🧠ANSWER ✔✔2-PAM
Atropine
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
3
STATEMENT. ALL RIGHTS RESERVED
QUESTIONS AND ANSWERS | 100%
PASS
Anticholinergics [not producing fluids/blood to heart, lungs and brain] syndrome
(antihistamines, bronchodilators, cyclic antidepressants, SLEEP AIDS) -
🧠ANSWER ✔✔Hot as a hare (hyperthermia)
Red as a beet (flushed)
Dry as a bone [ANHYDROSIS (dry skin, urinary retention)
Blind as a bat (mydriasis)
Mad as a hatter (hallucinations, delirium, myoclonic jerking)
The antidote for anticholinergic toxicity is physostigmine salicylate. Physostigmine
is the only reversible acetylcholinesterase inhibitor capable of directly
antagonizing the CNS manifestations of anticholinergic toxicity; it is an uncharged
tertiary amine that efficiently crosses the blood-brain barrier
,What does muscular rigidity cause - 🧠ANSWER ✔✔rhabdomylosis syndrome due
to a direct or indirect muscle injury. It results from the death of muscle fibers and
release of their contents into the bloodstream (myoglobin). This can lead to renal
(kidney) failure.
sympathomimetic [fight or flight/shunt blood going to heart/brain/lungs] -
🧠ANSWER ✔✔MIMIC SYMPATHETIC
a drug that stimulates the sympathetic branch of the autonomic nervous system
Epinephrine, adrenaline
Organophosphate poisoning
Cholinergics {see, spit, pee, shit] used in pesticides b/c - 🧠ANSWER ✔✔BUGS
DROWN with Cholinergic [producing fluids: saliva, urine, digestive enzymes]
Organophosphates are used as insecticides, medications, and nerve agents.
Symptoms include increased saliva and tear production, diarrhea, vomiting, small
pupils, sweating, muscle tremors, and confusion.
Cholinergics {see, spit, pee, shit] pathway - 🧠ANSWER ✔✔muscuric and
nicotinic receptors that use acetylcholine neurotransmitters
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
2
STATEMENT. ALL RIGHTS RESERVED
, cholinergic cells that use which neurotransmitter - 🧠ANSWER ✔✔Referring to
cells that use acetylcholine as their synaptic transmitter.
SLUDGE-bbb - 🧠ANSWER ✔✔Muscarinic Cholinergic syndrome
Salvation
lacrimination
urination
defecation
gastric emesis
bronchoria
bronchospasm
bradycardia
miosis
increased bowel sounds
Cholinergic Drug toxicity
antidote - 🧠ANSWER ✔✔2-PAM
Atropine
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
3
STATEMENT. ALL RIGHTS RESERVED
