Nur 641 E Final Exam Study Guide
Grand Canyon University
Comprehensive Questions (Frequently
Tested) with Verified Answers Graded
A+
absorption, distribution, metabolism, excretion - Answer: Pharmacokinetics involves
absorption from the administration site either directly or indirectly in the blood plasma -
Answer: Pharmacokinetic absorption
reversibly or irreversibly move from the bloodstream into the interstitial and intracellular fluid -
Answer: Parmacokinetic distribution
biotransformed via hepatic metabolism or by other tissue - Answer: Pharmacokinetics
metabolism
1. highest bioavailability
2. places entire does into venin thus bypassing absorption
3. avoids hepatic first pass metabolism in the liver - Answer: Intravenous medications
usually reached within 4-5 half lives of the drug - Answer: steady state medication
,1.the time required for the elimination process to reduce 2.the concentration of the drug to one
half what it was at initial administration
3.determines drug frequency
4. predicts length of toxic effects
5. constant first order pharmacokinetics of a drug - Answer: drug half life
drug is metabolized at a constant rate per unit - Answer: zero order (nonlinear)
metabolizes 50% drugs
inhibit: grapefruit juice
- increase drug -> adverse effects
may have enhanced activity with any other CYP3A4 - Answer: CYP3A4
1. discovery or laboratory for development
2. Phase 1 begins with animal testing
3. phase 2 human subjects
4. compare drug to placebo or other drug that is effective
5.FDA then reviews result and determines approval
6. Post market study to determine other side effects that were not seen while lab testing -
Answer: Six steps in drug development process
1.Institute of Safe mediation Practice
2. Institute of Medicine
3. Joint commission
4.National Coordinating Council form mediation error reporting and prevention
5. Food and Drug Administration (safe use initiative) - Answer: organizations for medication
safety
, 1.Also known as a side effect, an undesirable reaction that accompanies the principal response
for which the drug was taken include allergic reactions and adverse drug effects
2. Either pharmacological or idiosyncratic
3. 85-90% of ADRs are pharmacological
4. Reporting is not mandated by FDA thus are not commonly reported
5. usually preventable occur in hospital and nursing homes due to med errors
6. Polypharmacy, multiple doctors and multiple pharmacies increase risk - Answer: Adverse
Drug Reaction (ADR)
1. end in pril: lisinopril, captopril, enalapril, ramipril, benazepril and fosinopril
2. suppress release of angiotensin converting enzyme
3. side effects include cough and angioedema, with angioedema the medication should be
discontinued - Answer: Angiotensin-converting enzyme (ACE) inhibitors
1. -sartan: candesartan, eprosartan, ibesartan, Isosartan, telmisartan, valsartan
2.block angiotensin 11 receptors - Answer: Angiotensin II Receptor Blockers (ARBs)
Essential HTN accounts for 90% of cases and is also called primary, secondary may be caused by
CKD - Answer: Essential vs Secondary HTN
use: angina pectoris
action: dilate veins and arteries and thereby reducing ischemia and relieving pain by decreasing
myocardial O2 consumption
Side effects: throbbing HA, flushing, hypotension tachycardia
available: IV, SL, topical ointment and transdermal patch
contraindicated with PDE-5 (sildanfil and vardenafil) - Answer: Nitroglycerin (Nitrate)
Grand Canyon University
Comprehensive Questions (Frequently
Tested) with Verified Answers Graded
A+
absorption, distribution, metabolism, excretion - Answer: Pharmacokinetics involves
absorption from the administration site either directly or indirectly in the blood plasma -
Answer: Pharmacokinetic absorption
reversibly or irreversibly move from the bloodstream into the interstitial and intracellular fluid -
Answer: Parmacokinetic distribution
biotransformed via hepatic metabolism or by other tissue - Answer: Pharmacokinetics
metabolism
1. highest bioavailability
2. places entire does into venin thus bypassing absorption
3. avoids hepatic first pass metabolism in the liver - Answer: Intravenous medications
usually reached within 4-5 half lives of the drug - Answer: steady state medication
,1.the time required for the elimination process to reduce 2.the concentration of the drug to one
half what it was at initial administration
3.determines drug frequency
4. predicts length of toxic effects
5. constant first order pharmacokinetics of a drug - Answer: drug half life
drug is metabolized at a constant rate per unit - Answer: zero order (nonlinear)
metabolizes 50% drugs
inhibit: grapefruit juice
- increase drug -> adverse effects
may have enhanced activity with any other CYP3A4 - Answer: CYP3A4
1. discovery or laboratory for development
2. Phase 1 begins with animal testing
3. phase 2 human subjects
4. compare drug to placebo or other drug that is effective
5.FDA then reviews result and determines approval
6. Post market study to determine other side effects that were not seen while lab testing -
Answer: Six steps in drug development process
1.Institute of Safe mediation Practice
2. Institute of Medicine
3. Joint commission
4.National Coordinating Council form mediation error reporting and prevention
5. Food and Drug Administration (safe use initiative) - Answer: organizations for medication
safety
, 1.Also known as a side effect, an undesirable reaction that accompanies the principal response
for which the drug was taken include allergic reactions and adverse drug effects
2. Either pharmacological or idiosyncratic
3. 85-90% of ADRs are pharmacological
4. Reporting is not mandated by FDA thus are not commonly reported
5. usually preventable occur in hospital and nursing homes due to med errors
6. Polypharmacy, multiple doctors and multiple pharmacies increase risk - Answer: Adverse
Drug Reaction (ADR)
1. end in pril: lisinopril, captopril, enalapril, ramipril, benazepril and fosinopril
2. suppress release of angiotensin converting enzyme
3. side effects include cough and angioedema, with angioedema the medication should be
discontinued - Answer: Angiotensin-converting enzyme (ACE) inhibitors
1. -sartan: candesartan, eprosartan, ibesartan, Isosartan, telmisartan, valsartan
2.block angiotensin 11 receptors - Answer: Angiotensin II Receptor Blockers (ARBs)
Essential HTN accounts for 90% of cases and is also called primary, secondary may be caused by
CKD - Answer: Essential vs Secondary HTN
use: angina pectoris
action: dilate veins and arteries and thereby reducing ischemia and relieving pain by decreasing
myocardial O2 consumption
Side effects: throbbing HA, flushing, hypotension tachycardia
available: IV, SL, topical ointment and transdermal patch
contraindicated with PDE-5 (sildanfil and vardenafil) - Answer: Nitroglycerin (Nitrate)
