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NURS6630 ///NURS 6630 PSYCHOPHARMACOLOGY
MIDTERM EXAM 2 VERSIONS ACTUAL MIDTERM
EXAM SUMMER QRT| MOST RECENT WALDEN
UNIVERSITY|AGRADED
This extrapyramidal symptom is characterized by muscle rigidity (usually
in the facial muscles, giving the face a wooden mask-like appearance),
bradykinesia, and tremors. It can occur within a few days to a month of
Typical Antipsychotic use: -ANS-Pseudoparkinsonism
This extrapyramidal symptom is characterized by constant, involuntary,
rhythmic movements. usually of the perioral muscles, causing a person
to involuntarily smack or purse their lips. It can occur within a few
months to years of Typical Antipsychotic use: -ANS-Tardive Dyskinesia
Unlike more acute extrapyramidal symptoms, this one can be
irreversible and so the antipscyhotic should be discontinued at the first
sign: -ANS-Tardive Dyskinesia
The most dangerous and severe extrapyramidal symptom that typically
occurs within days or weeks of starting a Typical Antipsychotic: -ANS-
Neuroleptic Malignant Syndrome
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Seven symptoms associated with Neuroleptic Malignant Syndrome: -
ANS-confusion, coma, agitation, muscle rigidity, seizures, hyperthermia,
and hyporeflexia
This syndrome consists of confusion, coma, agitation, muscle rigidity,
seizures, hyperthermia, and HYPOreflexia: -ANS-Neuroleptic Malignant
Syndrome (caused by antipsychotics)
The two distinctions between Neuroleptic Malignant Syndrome and
Serotonin Syndrome: -ANS-HYPOreflexia and NORMAL pupils vs
HYPERreflexia and DILATED pupils
Advanced Neuroleptic Malignant Syndrome can cause: -ANS-
Rhabdomyolysis
Treatment of Neuroleptic Malignant Syndrome consists of: -ANS-
Dantrolene (muscle relaxant) and Dopamine agonists (bromocriptine)
Less severe neurotransmitter side effects of Typical Antipsychotics
include: -ANS-ORTHOSTATIC HYPOTENSION (Alpha-1 receptor
inhibition), ANTICHOLINERGIC SIDE EFFECTS (muscarinic receptor
inhibition), and SEDATION (H1 receptor inhibition).
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Which Typical Antipsychotics have a stronger sedating effect but less
extrapyramidal side effects? Low potency or High potency Typical
Antipsychotics: -ANS-Low potency
Metabolic side effects of Typical Antipsychotics include: -ANS-Weight
gain, dyslipidemia, and hyperglycemia
Cardiac side effects of Typical Antipsychotics include: -ANS-Prolongation
of the QT interval (normal = 0.4-0.44 seconds)
Typical Antipsychotic, chlorpromazine specific side effects: -ANS-Corneal
deposits
Typical Antipsychotic, thioridazine specific side effects: -ANS-Retinal
deposits
Block Dopamine D2 receptors in the Mesolimbic pathway to alleviate
positive symptoms of psychosis (hallucinations, delusions, disorganized
thoughts) and block Serotonin 5-HT2A receptors in the Mesocortical
pathway that usually prevent Dopamine release from dopaminergic
neurons, thus increasing mesolimbic dopamine levels and improving
negative symptoms of psychosis (lack of motivation, social withdrawal,
and flat affect): -ANS-Atypical Antipsychotics
NURS6630 ///NURS 6630 PSYCHOPHARMACOLOGY
MIDTERM EXAM 2 VERSIONS ACTUAL MIDTERM
EXAM SUMMER QRT| MOST RECENT WALDEN
UNIVERSITY|AGRADED
This extrapyramidal symptom is characterized by muscle rigidity (usually
in the facial muscles, giving the face a wooden mask-like appearance),
bradykinesia, and tremors. It can occur within a few days to a month of
Typical Antipsychotic use: -ANS-Pseudoparkinsonism
This extrapyramidal symptom is characterized by constant, involuntary,
rhythmic movements. usually of the perioral muscles, causing a person
to involuntarily smack or purse their lips. It can occur within a few
months to years of Typical Antipsychotic use: -ANS-Tardive Dyskinesia
Unlike more acute extrapyramidal symptoms, this one can be
irreversible and so the antipscyhotic should be discontinued at the first
sign: -ANS-Tardive Dyskinesia
The most dangerous and severe extrapyramidal symptom that typically
occurs within days or weeks of starting a Typical Antipsychotic: -ANS-
Neuroleptic Malignant Syndrome
,2|Page
Seven symptoms associated with Neuroleptic Malignant Syndrome: -
ANS-confusion, coma, agitation, muscle rigidity, seizures, hyperthermia,
and hyporeflexia
This syndrome consists of confusion, coma, agitation, muscle rigidity,
seizures, hyperthermia, and HYPOreflexia: -ANS-Neuroleptic Malignant
Syndrome (caused by antipsychotics)
The two distinctions between Neuroleptic Malignant Syndrome and
Serotonin Syndrome: -ANS-HYPOreflexia and NORMAL pupils vs
HYPERreflexia and DILATED pupils
Advanced Neuroleptic Malignant Syndrome can cause: -ANS-
Rhabdomyolysis
Treatment of Neuroleptic Malignant Syndrome consists of: -ANS-
Dantrolene (muscle relaxant) and Dopamine agonists (bromocriptine)
Less severe neurotransmitter side effects of Typical Antipsychotics
include: -ANS-ORTHOSTATIC HYPOTENSION (Alpha-1 receptor
inhibition), ANTICHOLINERGIC SIDE EFFECTS (muscarinic receptor
inhibition), and SEDATION (H1 receptor inhibition).
, 3|Page
Which Typical Antipsychotics have a stronger sedating effect but less
extrapyramidal side effects? Low potency or High potency Typical
Antipsychotics: -ANS-Low potency
Metabolic side effects of Typical Antipsychotics include: -ANS-Weight
gain, dyslipidemia, and hyperglycemia
Cardiac side effects of Typical Antipsychotics include: -ANS-Prolongation
of the QT interval (normal = 0.4-0.44 seconds)
Typical Antipsychotic, chlorpromazine specific side effects: -ANS-Corneal
deposits
Typical Antipsychotic, thioridazine specific side effects: -ANS-Retinal
deposits
Block Dopamine D2 receptors in the Mesolimbic pathway to alleviate
positive symptoms of psychosis (hallucinations, delusions, disorganized
thoughts) and block Serotonin 5-HT2A receptors in the Mesocortical
pathway that usually prevent Dopamine release from dopaminergic
neurons, thus increasing mesolimbic dopamine levels and improving
negative symptoms of psychosis (lack of motivation, social withdrawal,
and flat affect): -ANS-Atypical Antipsychotics
