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Samenvatting examenvragen deel 1

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Bij het vak farmacologie is het zeer belangrijk dat je goed begrijpt waar de geneesmiddelen op ingrijpen en wat hun mogelijke bijwerkingen zijn die uit het werkingsmechanisme volgen. Behaalde resultaat 18/20.

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Ex-examenvragen

Vraag 1

 Affiniteit/potentie  EC50
 Intrinsieke activiteit  effectiviteit/ het maximum effect
 Irreversibele competitieve antagonist gaat maximum onderdrukken maar zorgt niet voor een
links rechts veschuiving van de dosis antwoord curve




Vraag 2

 Bij gelijke klaring  t1/2 = 0.7 x VD/CL
 Als VD groter wordt dan wordt t1/2
 Plasma 1/2t is onafhankelijk van de dosis bij eerste orde kinetiek (bij verzadigingskinetiek is
dit niet het geval)

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