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VERSION A
Which statement relates to immune thrombocytopenic purpura (ITP)?
a.
ITP is formed in conditions of low flow and is made up of mostly red cells with larger amounts of
fibrin and few platelets.
b.
An alteration of multipotent stem cells, resulting in an excess production of platelets, causes ITP.
c.
Mononuclear phagocytes in the spleen remove antibody-coated platelets from circulation.
d.
Arterial clots are made up of mostly platelet aggregates held together by fibrin strands.
C
ITP involves the antigen usually forming immune complexes with circulating antibodies, and it
is thought that the immune complexes bind to Fc receptors on platelets, leading to their
destruction in the spleen. None of the other options are accurately related to ITP.
When the demand for mature neutrophils exceeds the supply, immature neutrophils are
released indicating:
a.
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,A shift to the right
c.
Leukocytosis
b.
A shift to the left
d.
Leukemia
B
When the demand for circulating mature neutrophils exceeds the supply, the marrow begins
to release immature neutrophils (and other leukocytes) into the blood. Premature release of
the immature white cells is responsible for the phenomenon known as a shift to the left or
leukemoid reaction. None of the remaining options would be used to identify the process
described.
Hodgkin disease is characterized by the presence of which of the following?
a.
Philadelphia chromosome
c.
Microvascular thrombi
b.
Virchow triad
d.
Reed-Sternberg (RS) cells
D
Hodgkin disease is characterized by its progression from one group of lymph nodes to
another, the development of systemic symptoms, and the presence of RS cells (see Figure 29-
8), but not the involvement of the Philadelphia chromosome. Virchow triad is a symptom
related to thrombus formation. Disseminated intravascular coagulation is associated with
microvascular thrombi.
Which classic clinical manifestations are symptoms of IM? (Select all that apply.)
a.
Lymph node enlargement
b.
Hepatitis
c.
Pharyngitis
d.
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,Edema in the area of the eyes
e.
Fever
A, C, E
At the time of diagnosis, the individual usually has the classic triad of symptoms: fever,
pharyngitis, and lymphadenopathy of the cervical lymph nodes. The triad does not include
hepatitis or orbital edema.
Early detection of acute leukemia would include which of the following symptoms? (Select all
that apply.)
a.
Dizziness
b.
Paresthesia
c.
Anorexia
d.
Bruising
e.
Bone pain
C, D, E
Signs and symptoms related to bone marrow depression include fatigue caused by anemia,
bleeding resulting from thrombocytopenia (reduced numbers of circulating platelets), and
fever caused by infection. Anorexia can occur in all varieties of acute leukemia and is
associated with weight loss. Pain in the bones and joints is thought to result from leukemia
infiltration with secondary stretching of the periosteum. The other options are not generally
associated with acute leukemia.
What are the most significant risk factors for the development of thrombus formation as
referred to by the Virchow triad? (Select all that apply.)
a.
Endothelial injury to blood vessels
b.
Turbulent arterial blood flow
c.
Rapid coagulation of the blood
d.
Stagnant venous blood flow
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, e.
History of obesity
A, B, C, D
The risk for developing spontaneous thrombi is related to several factors, referred to as the
Virchow triad: (1) injury to the blood vessel endothelium, (2) abnormalities of blood flow, and
(3) hypercoagulability of the blood. Obesity is not associated with the triad.
Which statements are true regarding leukemias? (Select all that apply.)
a.
A single progenitor cell undergoes a malignant change.
b.
Leukemia is a result of uncontrolled cellular proliferation.
c.
Bone marrow becomes overcrowded.
d.
Leukocytes are under produced.
e.
Hematopoietic cell production is decreased.
A, B, C, E
In the leukemias, a single progenitor cell undergoes malignant transformation. The common
feature of all forms of leukemia is an uncontrolled proliferation of malignant leukocytes,
causing an overcrowding of bone marrow and decreased production and function of normal
hematopoietic cells.
The two major forms of leukemia, acute and chronic, are classified by which criteria? (Select all
that apply.)
a.
Predominant cell type
b.
Rate of progression
c.
Age of individual when cells differentiation occurs
d.
Stage of cell development when malignancy first occurs
e.
Serum level of leukocytes
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