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Genetic Manipulation

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Advances in gene manipulation have given rise to practical applications in myriad fields including agriculture, medicine, and research. Sentinel plants are able to fluoresce when they need water, and spinal cord injuries are able to be healed in mouse models using manipulated stem cells

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Advances in gene manipulation have given rise to practical applications in myriad fields

including agriculture, medicine, and research. Sentinel plants are able to fluoresce when they

need water, and spinal cord injuries are able to be healed in mouse models using manipulated

stem cells. All of these technologies have come to the point where they are being heavily

scrutinized by bioethicists and the general public. In some cases, such as human cloning,

legislation was swiftly enacted in order to prevent the technology from being put into practice.

In other arenas, such as genetically modifying food crops and embryonic stem cells, the debate is

currently being fought. There are well-funded lobbyists and salient points on both sides;

however the criticisms of these technologies are far overshadowed by the benefits they can

provide. Genetically modified organisms can be manipulated so that they provide all the

nutrients people in developing nations need. Stem cell technologies use IVF fetuses that will be

destroyed, and can possibly cure Parkinson’s and diabetes, saving millions from the fate of

vanishing cognition, vision loss, and amputation. As the criticisms are examined, it will become

clear that they are often grounded in appeals to emotion and other logically fallacies.

, There is much public debate about the use of genetic manipulation, but when time is

taken to research GMOs, cloning, and adaptive stem cell technologies, it is obvious that these

activities greatly benefit mankind. Some people feel that scientists are “playing God,” and other

people worry that foods and animals produced using such technologies are unsafe. Still others

grapple with the ethics of financial gain or the seeking of patents for living things. Finally, it is

of great concern that these technologies will be used to tamper with the human organism, which

is often seen by many to be distinct and superior to the other kingdoms of life. However, we will

see that these technologies allow us to develop medications, reduce the cost and number of

animals used for laboratory experiments, and feed developing nations through the development

of more nutritious strains of food crops. The safety and efficacy of these plants and animals is

such that it would be more unethical not to use them.

Jumba defines GMOs, or genetically modified organisms, as “an organism whose genetic

make-up has been deliberately altered” (2010, p. 1). It also includes various technological

approaches that can be used to realize these goals, including recombinant DNA technology,

genetic engineering, and genetic modification. A clone can be defined as a genetic replica of the

original cell, tissue line, individual, or animal (Simon et al., 2010). Finally, stem cell lines are

proliferated cells that are pluripotent in nature, and can take on specialization depending on

where they migrate to in the body (find source for final submission). These technologies in the

minds of the public have legal, ethical, and religious dimensions, and few do not have strong

feelings about their use.

GMOs
GMOs, as defined above, have many practical applications. One of these applications is

in the field of agriculture, where plants are genetically manipulated in order to withstand greater

applications of pesticides, increase their nutritional value, and even phosphoresce if they need to

, be watered (thanks to jellyfish genes) (Zimmer, 2005). These “sentinel” plants are not meant for

human consumption; rather they are planted at regular intervals around food beds in order to

alert farmers that their crops need to be watered. Because they are not being eaten, there is no

need to worry about consuming GMOs for those who worry about doing so (as the research

shows, unnecessarily). These florescent genes can also be used as biomarkers in animal

research, and has been developed to include gold, blue, citrine, cyan, and yellow in addition to

green.

Another application of GMOs is to reduce diversity in laboratory animals (Cibelli et al.,

2014). With less genetic diversity, confounding factors related to heredity are eliminated.

Interestingly, the use of clones can eliminate the study pool of animals, since heterogeneous

animals can cause a coefficient greater than .90. Cibelli et al. note that a study pool can be

reduced to N2, down from a study pool of forty, and of course animal welfare advocates will

appreciate this fact as well. The maintenance of study animals costs researches $3,000-$6,000

per animal annually, so this technology will also help to expand research by lowering overhead.

Especially in the research areas of disease prevention and cure this technology will represent a

great humanistic achievement.

GMOs are also used to engineer plants that are better able to withstand pesticide

application with the goal of increasing yield; however they can also be manipulated in order to

innately increase resistance to viruses, bacteria, and insects (Velander et al., 1997). Plants have

been manipulated to produce healthier oils, and hormones created by bacteria have been used to

increase milk production in cows (Jumba, 2010).

Medical Interventions
There are different ways that GMOs can be used to assist with providing healthcare.

Animals that produce needed proteins can be transported to areas of the globe where

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Uploaded on
March 7, 2025
Number of pages
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Written in
2024/2025
Type
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Grade
A

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