CPJE Clinical Info Complete Solution 100% Verified

CPJE Clinical Info Complete Solution 100% Verified Tylenol (I,D,Overdose) - ANS-Acetaminophen I: fever/pain D: 325-650mg, max < 4000mg/day from all sources *OD = liver damage, use NAC for antidote no anti platelet activity DOC for pain in pregnancy or use with warfarin Ofirmev (IV) (I,D,Overdose) - ANS-Acetaminophen I: fever/pain D: < 4000mg/day from all sources *Can treat more severe pain *OD = liver damage, use NAC for antidote no anti platelet activity NAC (I) - ANS-N-acetylcysteine I: APAP overdose Compatible with: D5W, ½ NS, and Water for Injection Stable for 24h at room temp COX-1 selective NSAIDs - ANS-indomethacin, ketorlac COX-1 selective = higher risk for GI bleeding COX-2 selective NSAIDs - ANS-Celecoxib Diclofenac Meloxicam Etodolac Nabumetone COX-2 selective = higher risk of CV events (MI, stroke) COX 1 and COX 2 non-selective NSAIDs - ANS-ibuprofen, naproxen, piroxicam, sulindac COX-1 = higher risk for GI bleeding COX-2 = higher risk of CV events (MI, stroke) Daypro (I,D, BBW) - ANS-Oxaprozin I: fever/pain/inflammation *Similar caution to piroxicam: high risk for GI tox and severe SJS Dose: 1200 mg once daily w/ max of 1800 mg if >50 kg BBW: COX non-selective: GI bleeding and CV thrombotic event risk SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic + ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib) **FDA safety alert: Caution with use in pregnancy after 20 weeks, can cause fetal renal tox / oligohydroaminos, avoid use after 30 weeks due to risk of premature closure of fetal ductus arteriosus CI: for use in patients w/ CABG surgery requires med guide to be dispensed Ascriptin, Bufferin, Ecotrin (I,D,CI,OD,BBW) - ANS-Aspirin (Bayer) I: fever/pain/inflammation D: 81-325mg qd CI: pregnancy (esp 3rd trimester), OD = tinnitis *BBW: COX-1 selectivity NSAID = GI bleed Avoid in children < 16 with any vial infection due to potential risk of Reye's syndrome irreversible antiplatelet, GI toxicity Naprosyn (I,D,BBW) - ANS-Naproxen, Aleve I: fever/pain/inflammation -OTC: 220mg qd -Rx: 250-550mg bid *Higher GI side effects *BBW: COX-1/2 selectivity NSAID = GI bleed and CV tox SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic + ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib) CI: for use in patients w/ CABG surgery requires med guide to be dispensed Motrin, Advil (I,D,BBW, SE, CI) - ANS-Ibuprofen I: fever/pain/inflammation Dose -OTC: 200-400mg q 4-6 hrs -Rx: 600-800 mg tid, max 3200mg/d child: 10mg/kg/dose with max 40mg/kg/day COX non-selective: GI bleeding and CV thrombotic event risk Continues....