Genetic Exam 2 - Chapter 11
genetic Heterogeneity
Mutations in two different genes can produce the same disease
Genetic Complementation
Two different mutant phenotypes produce offspring with the wild-type phenotype
Brainpower
Read More
Osteogenesis Imperfecta is an example of what genetic principle?
- Genetic Heterogeneity
Cystic Fibrosis
- What are the five classes?
- Class I - No functional CFTR made
- Class II - CFTR protein misfolded and cannot make it to cell surface
- Class III - CFTR protein makes it to surface but CANNOT function properly
- Class IV - opening in CFTR ion channel is faulty
- Class V - everything works but not enough made
Modifier Gene
- Gene that alters the phenotype of a different gene
Digenic Inheritance
a characteristic controlled by two genes
- Determined by the additive effect of two genes
Retinis Pigmentose is an example of what type of inheritance?
- Digenic
- Have to be homozygous at either allele
, Polygenic Inheritance
combined effect of two or more genes on a single character
- Contribution of many genes at different loci, with each gene contributing to the trait
monogenic traits
Trait in which there are only two possible phenotypes
Controlled by only one gene
Polygenic Traits
Number of phenotypes are numerous
Controlled by a number of genes
Discontinuous/Discrete Traits
traits that are clearly different from each other
- ex. Hair Line is either Widow's peak or flat
Continuous/Quantitative Traits
- continuous distribution of phenotypes
- Has quantitative value
- Height, IQ, etc
Experiment of Johannsen
- Showed proof of quantitative traits
- Showed normal distribution of a group of peas
- Took homozygous peas (same traits) at different heights and grew them out separately
- Found that even at starting different heights, the produced peas all produced plants of
different heights
The more genes you have contributing to a trait, the more ________ and _________ the
distribution of traits gets
- more genes, the more BROAD and SMOOTH the distribution of traits
genetic Heterogeneity
Mutations in two different genes can produce the same disease
Genetic Complementation
Two different mutant phenotypes produce offspring with the wild-type phenotype
Brainpower
Read More
Osteogenesis Imperfecta is an example of what genetic principle?
- Genetic Heterogeneity
Cystic Fibrosis
- What are the five classes?
- Class I - No functional CFTR made
- Class II - CFTR protein misfolded and cannot make it to cell surface
- Class III - CFTR protein makes it to surface but CANNOT function properly
- Class IV - opening in CFTR ion channel is faulty
- Class V - everything works but not enough made
Modifier Gene
- Gene that alters the phenotype of a different gene
Digenic Inheritance
a characteristic controlled by two genes
- Determined by the additive effect of two genes
Retinis Pigmentose is an example of what type of inheritance?
- Digenic
- Have to be homozygous at either allele
, Polygenic Inheritance
combined effect of two or more genes on a single character
- Contribution of many genes at different loci, with each gene contributing to the trait
monogenic traits
Trait in which there are only two possible phenotypes
Controlled by only one gene
Polygenic Traits
Number of phenotypes are numerous
Controlled by a number of genes
Discontinuous/Discrete Traits
traits that are clearly different from each other
- ex. Hair Line is either Widow's peak or flat
Continuous/Quantitative Traits
- continuous distribution of phenotypes
- Has quantitative value
- Height, IQ, etc
Experiment of Johannsen
- Showed proof of quantitative traits
- Showed normal distribution of a group of peas
- Took homozygous peas (same traits) at different heights and grew them out separately
- Found that even at starting different heights, the produced peas all produced plants of
different heights
The more genes you have contributing to a trait, the more ________ and _________ the
distribution of traits gets
- more genes, the more BROAD and SMOOTH the distribution of traits
