PH & PKa
of dissociation
Key forey Rin AtBX+d the
equilibrom constant,
key
degree
the
givesEquilibrium
, ,
.
keg [productseq]
=
=
[Cg[Deg] in Defines THE compostion As WHEN CONCENTRATIONS Are
[REACTANSegJ
[teg] [Beg]
-To
longer changing
Kn-water ionreatron Constant
kn =
[H20] (key =
[N]CH JSOH] +
= [H J [OH-]
+
Note : As
Equilibrium , The concentration of IzO is
[O] 55 .
5M
↑ 25°, Kwis 1 0
. x 10-14 M3
-
Ka-The Acid dissociation of Weak Acids How Acid Holds Weaker Acids Hold
Tightly procou
Constant .
Measures an on To Ms .
ka [H ] [A-]
+
keg and are less dissociate Ka-
Ther
protons Likely Thus
They have a
=
=
Onto to . ,
small
[HA] Acids : Ifor reference hats a work foid and
WEAK SMALL Ka debase
longingCOMPLETE
res
Aoids: Ka Acids
Strong Bog
vost : Almost
strang
WILL
>
PKa-THE inverse of The Ka describe of Acids
- Fontte/Dissociate
THE DO not Hold
Aqueous
in
Their
solutions
PROTO
log STRENGTH
, used To THE 5 ,
On To
PKa
-log(ka) Log WEAK Acids:Small Ka,
BigPKa
Pla
Try strongly
INSTEAD,
They Tend to Don
=
or .
Ka
Bug
Acros : SMALL
Strong
,
PH -Expresses The Concentration of t
solution . Ph and PKa Are RELATED via The Henderson-Hasselbach :
aqueous
Ions in an
Equ
PH +
+
-Log[H ]
=
LogCity
or
PKatLog The
hererson-Hasselbach
PH =
for PHAPK
PH is A Lo ArMAMic SCALE Each
Equation
g
, a
Higher
increase 10-fold They The inverse Tha THE CHT]
log
is a increase in :
makes r So is, The Lower The
PHA
HigHCH
Vice VERSA +
.
] -
>
Low PH
-
Low [H -
+
Phys ICAL PH :
High
PH
rozog
>
&
234567891011 12 13 14
Acidic Basic/ALKALINE
-
6-
5
↓
HAs A PH of 2 THE
Example : LEMON
joice <6 5 NEUTRAL 7 54
↳
. . .
6 5-7 5
.
.
CONCENTRATion of [Htj is 1
.
0x103 M
Buffers find CHt] and [AS
BufferingRange-the
& TiTratton curve Below Can Be used to THE Ph WHERE are
This is THE PKa HOWEVER PKaEI This is due BuffERS Acid BASE RESIST
Equal Changes
A WEAK tiTS
Conjugate
.
. THERES An Allowance : .
TO
,
Buffers Are Essential from
Brozog
TOCH] & [A-]
Biolog Damag
in THE PROTECT ICAL Molecules
Range
WITHIN A CERTAIN .
.
7
Due Pt
L Histidine And Buffers
changes
Extreme in Appare oud As
They
To
g
.
CAN Exist As PROTONATEd or DEPROTONATED Al Physio iCAL PH
9
Bonging
Acidosis Blood Acidic Blood plasma Buffered
: is 700
>
-
-
is
By
ALKALOSIS : Blood S Too Basic THE BICARBONATE SYSTEM
# HCO3HeCOzT HOt C
*
PROTON
Production of HyCO3
PROTON
CAN BE Acceptor DONOR
of
By
RegulatingExchange COzig) (Bresting
MANPUAED
Acidosis - increase of CO2 , Body [CO2]
Lowering
Exalation in THE .
ALKALOSIs- Slow [202]
Breathing
Rate TO increase
I
of dissociation
Key forey Rin AtBX+d the
equilibrom constant,
key
degree
the
givesEquilibrium
, ,
.
keg [productseq]
=
=
[Cg[Deg] in Defines THE compostion As WHEN CONCENTRATIONS Are
[REACTANSegJ
[teg] [Beg]
-To
longer changing
Kn-water ionreatron Constant
kn =
[H20] (key =
[N]CH JSOH] +
= [H J [OH-]
+
Note : As
Equilibrium , The concentration of IzO is
[O] 55 .
5M
↑ 25°, Kwis 1 0
. x 10-14 M3
-
Ka-The Acid dissociation of Weak Acids How Acid Holds Weaker Acids Hold
Tightly procou
Constant .
Measures an on To Ms .
ka [H ] [A-]
+
keg and are less dissociate Ka-
Ther
protons Likely Thus
They have a
=
=
Onto to . ,
small
[HA] Acids : Ifor reference hats a work foid and
WEAK SMALL Ka debase
longingCOMPLETE
res
Aoids: Ka Acids
Strong Bog
vost : Almost
strang
WILL
>
PKa-THE inverse of The Ka describe of Acids
- Fontte/Dissociate
THE DO not Hold
Aqueous
in
Their
solutions
PROTO
log STRENGTH
, used To THE 5 ,
On To
PKa
-log(ka) Log WEAK Acids:Small Ka,
BigPKa
Pla
Try strongly
INSTEAD,
They Tend to Don
=
or .
Ka
Bug
Acros : SMALL
Strong
,
PH -Expresses The Concentration of t
solution . Ph and PKa Are RELATED via The Henderson-Hasselbach :
aqueous
Ions in an
Equ
PH +
+
-Log[H ]
=
LogCity
or
PKatLog The
hererson-Hasselbach
PH =
for PHAPK
PH is A Lo ArMAMic SCALE Each
Equation
g
, a
Higher
increase 10-fold They The inverse Tha THE CHT]
log
is a increase in :
makes r So is, The Lower The
PHA
HigHCH
Vice VERSA +
.
] -
>
Low PH
-
Low [H -
+
Phys ICAL PH :
High
PH
rozog
>
&
234567891011 12 13 14
Acidic Basic/ALKALINE
-
6-
5
↓
HAs A PH of 2 THE
Example : LEMON
joice <6 5 NEUTRAL 7 54
↳
. . .
6 5-7 5
.
.
CONCENTRATion of [Htj is 1
.
0x103 M
Buffers find CHt] and [AS
BufferingRange-the
& TiTratton curve Below Can Be used to THE Ph WHERE are
This is THE PKa HOWEVER PKaEI This is due BuffERS Acid BASE RESIST
Equal Changes
A WEAK tiTS
Conjugate
.
. THERES An Allowance : .
TO
,
Buffers Are Essential from
Brozog
TOCH] & [A-]
Biolog Damag
in THE PROTECT ICAL Molecules
Range
WITHIN A CERTAIN .
.
7
Due Pt
L Histidine And Buffers
changes
Extreme in Appare oud As
They
To
g
.
CAN Exist As PROTONATEd or DEPROTONATED Al Physio iCAL PH
9
Bonging
Acidosis Blood Acidic Blood plasma Buffered
: is 700
>
-
-
is
By
ALKALOSIS : Blood S Too Basic THE BICARBONATE SYSTEM
# HCO3HeCOzT HOt C
*
PROTON
Production of HyCO3
PROTON
CAN BE Acceptor DONOR
of
By
RegulatingExchange COzig) (Bresting
MANPUAED
Acidosis - increase of CO2 , Body [CO2]
Lowering
Exalation in THE .
ALKALOSIs- Slow [202]
Breathing
Rate TO increase
I
