Chemotherapy Agents Practice Questions with Complete Solutions

Which of the following is a dihydrofolate reductase (DHFR) inhibitor? *A.* Pemetrexed *B.* Doxorubicin *C.* Docetaxel *D.* 5-Fluorouracil *E.* Ixabepilone Correct Answer *A.* Pemetrexed Which of the following is a cell-cycle specific agent that works in the M phase? *A.* Bevacizumab *B.* Paclitaxel *C.* Oxaliplatin *D.* Methotrexate *E.*Capecitabine Correct Answer *B.* Paclitaxel Which of the following is an alkylating agent? *A.* Ixabepilone *B.* 6-Thioguanine *C.* Bortezomib *D.* Doxorubicin *E.* Cyclophosphamide Correct Answer *E.* Cyclophosphamide Which of the following cell-cycle specific drugs does not have a dose limiting toxicity of myelosuppression? *A.* Capecitabine *B.* Cytarabine *C.* Methotrexate *D.* Vinblastine *E.* Bolus 5-fluorouracil Correct Answer *A.* Capecitabine Which of the following is not a noteworthy toxicity of cytarabine? *A.* Flu-like symptoms *B.* Myelosuppression *C.* Nephrotoxicity *D.* Ocular toxicities *E.* Cerebellar toxicities Correct Answer *C.* Nephrotoxicity