systemic lupus erythematosus
* chronic , multi system inflammatory disease
* associated with abnormalities of immune
system
* results from interactions
among genetic , hormonal , environmental , and immunological
* SLE affects 1 per 1000
people in Canada
* nine times more
likely in women than men
has effects joints renal system
* on : skin , , serous membranes , , hematological system ,
neurological system
etiology and pathophysiology >
etiology is unknown
most probable causes : autoimmune reactions directed against constituents of cell nucleus .
DNA
antibody B- T-cell
response related to and hyperactivity
clinical manifestations & complications
*
ranges from a relatively mild disorder to
rapidly progressive ,
affecting many body systems
* Most
commonly affects the skin and muscles , lining of lungs ,
heart ,
nervous tissue , and kidneys
derm : alopecia , butterfly rash , discoid erythema , palmar erythema ,
mucosal ulcers
CNS : stroke , seizures , peripheral neuropathy ,
psychosis ,
organic brain syndrome
CPS : endocarditis ,
myocarditis , pericarditis , pleural effusion .
pneumonitis , Raynaud 's phenomenon
hema : anemia , leucopenia ,
lymphadenopathy ,
splenomegaly , thrombocytopenia
GI : abdominal pain , diarrhea ,
dysphagia , nausea &
vomiting
GU :
glomerulonephritis ,
hematuria , protein urea , menstral
irregularities
MSK : arthritis , myostitis , synovitis
diagnostic studies →
there is no specific test →
diagnosed primarily on criteria relating to client
history physical , examination . and laboratory findings
criteria for diagnosis of SLE : antinuclear antibodies
arthritis →
non erosive ,
involvement of two or more joints characterized by tenderness ,
swelling ,
and effusion
discoid rash
hematological hemolytic leucopenia lymphopenia thrombocytopen
disorder →
anemia .
,
, or
immunological disorder → positive result of LE preparation ; anti -
DNA
antibody or
antibody to Sm false positive result of
nuclear antigen ; or
-
serological tests for syphilis
Malar rash
neurological disorders :
seizures or
psychosis
oral ulcers
photosensitivity
renal disorder :
persistent proteinuria or cellular casts in urine
serositis →
pleuritis or pericarditis
* chronic , multi system inflammatory disease
* associated with abnormalities of immune
system
* results from interactions
among genetic , hormonal , environmental , and immunological
* SLE affects 1 per 1000
people in Canada
* nine times more
likely in women than men
has effects joints renal system
* on : skin , , serous membranes , , hematological system ,
neurological system
etiology and pathophysiology >
etiology is unknown
most probable causes : autoimmune reactions directed against constituents of cell nucleus .
DNA
antibody B- T-cell
response related to and hyperactivity
clinical manifestations & complications
*
ranges from a relatively mild disorder to
rapidly progressive ,
affecting many body systems
* Most
commonly affects the skin and muscles , lining of lungs ,
heart ,
nervous tissue , and kidneys
derm : alopecia , butterfly rash , discoid erythema , palmar erythema ,
mucosal ulcers
CNS : stroke , seizures , peripheral neuropathy ,
psychosis ,
organic brain syndrome
CPS : endocarditis ,
myocarditis , pericarditis , pleural effusion .
pneumonitis , Raynaud 's phenomenon
hema : anemia , leucopenia ,
lymphadenopathy ,
splenomegaly , thrombocytopenia
GI : abdominal pain , diarrhea ,
dysphagia , nausea &
vomiting
GU :
glomerulonephritis ,
hematuria , protein urea , menstral
irregularities
MSK : arthritis , myostitis , synovitis
diagnostic studies →
there is no specific test →
diagnosed primarily on criteria relating to client
history physical , examination . and laboratory findings
criteria for diagnosis of SLE : antinuclear antibodies
arthritis →
non erosive ,
involvement of two or more joints characterized by tenderness ,
swelling ,
and effusion
discoid rash
hematological hemolytic leucopenia lymphopenia thrombocytopen
disorder →
anemia .
,
, or
immunological disorder → positive result of LE preparation ; anti -
DNA
antibody or
antibody to Sm false positive result of
nuclear antigen ; or
-
serological tests for syphilis
Malar rash
neurological disorders :
seizures or
psychosis
oral ulcers
photosensitivity
renal disorder :
persistent proteinuria or cellular casts in urine
serositis →
pleuritis or pericarditis
