NR565 Advanced Pharmacology Fundamentals
Questions with Correct Solutions A+ Grade |
2026/2027 Comprehensive Study Guide
Terms in this set (287)
Pharmacokinetics The process by which drugs are absorbed,
distributed within the body, metabolized, and
excreted.
Pharmacodynamics The study of what the drug does to the body
Factors Affecting Drug Absorption Rate of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning
,Factors Affecting Drug Distribution Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
Xenobiotics substances that are foreign to the body, usually
synthetic chemical compounds; medications are
a common example
Cytochrome P450 (CYP450) xenobiotic-metabolizing enzymes necessary for
the production of cholesterol and steroids and
the detoxification of chemicals and drug
metabolism.
Function of Cytochrome P450 responsible for phase 1 metabolism in which
(CYP450) drugs are oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Drugs via Oxidation; Reduction; Hydrolysis
P450
Three possible outcomes of phase 1 -Drug becomes completely inactive
drug metabolism.
-Drug becomes partially inactive but one or
more metabolites remain active
-Original drug is not pharmacologically active
but one metabolite remains active
CYP450 Inducers Medications that can increase the rate of another
drug's metabolism by elevating CYP450 enzyme
activity via increasing enzyme synthesis.
decreasing the concentration of the "parent
drug"
, CYP450 Inducer Medications CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
CYP450 Inhibitors Medications that inhibit the metabolic activity of
one or more of the CYP450 enzymes. Higher risk
for toxicity; prolongs the pharmacological effect
of the "parent drug".
CYP450 Inhibitor Medications VISACKGQ
Valproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine
Questions with Correct Solutions A+ Grade |
2026/2027 Comprehensive Study Guide
Terms in this set (287)
Pharmacokinetics The process by which drugs are absorbed,
distributed within the body, metabolized, and
excreted.
Pharmacodynamics The study of what the drug does to the body
Factors Affecting Drug Absorption Rate of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning
,Factors Affecting Drug Distribution Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
Xenobiotics substances that are foreign to the body, usually
synthetic chemical compounds; medications are
a common example
Cytochrome P450 (CYP450) xenobiotic-metabolizing enzymes necessary for
the production of cholesterol and steroids and
the detoxification of chemicals and drug
metabolism.
Function of Cytochrome P450 responsible for phase 1 metabolism in which
(CYP450) drugs are oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Drugs via Oxidation; Reduction; Hydrolysis
P450
Three possible outcomes of phase 1 -Drug becomes completely inactive
drug metabolism.
-Drug becomes partially inactive but one or
more metabolites remain active
-Original drug is not pharmacologically active
but one metabolite remains active
CYP450 Inducers Medications that can increase the rate of another
drug's metabolism by elevating CYP450 enzyme
activity via increasing enzyme synthesis.
decreasing the concentration of the "parent
drug"
, CYP450 Inducer Medications CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
CYP450 Inhibitors Medications that inhibit the metabolic activity of
one or more of the CYP450 enzymes. Higher risk
for toxicity; prolongs the pharmacological effect
of the "parent drug".
CYP450 Inhibitor Medications VISACKGQ
Valproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine
