Mosby's Canadian Nursing Drug Reference,
2nd Edition
Authors :
Linda Skidmore-Roth & Faith Richardson
NCLEX-Style MCQs based strictly on
Mosby’s Canadian Nursing Drug Reference,
2nd Edition for the specified
Gastrointestinal Drugs.
1.
A nurse is administering omeprazole for GERD. What is the
primary mechanism of action?
A. Neutralizes gastric acid
B. Blocks histamine receptors in the stomach
,C. Inhibits the proton pump in gastric parietal cells
D. Coats the gastric mucosa
Answer: C
Rationale:
Omeprazole is a proton pump inhibitor (PPI) that suppresses
gastric acid secretion by inhibiting the H⁺/K⁺ ATPase pump in
parietal cells.
• A: Antacids
• B: H2 blockers (famotidine)
• D: Sucralfate
Citation: Mosby’s Canadian Nursing Drug Reference (2nd ed.),
Omeprazole
2.
Which instruction should the nurse give a patient taking
omeprazole?
A. Take with antacids
B. Take before meals
C. Crush the tablet before taking
D. Take at bedtime only
Answer: B
,Rationale:
Omeprazole should be taken before meals, typically in the
morning, for optimal acid suppression.
• C: Enteric-coated—do not crush
• A: May interfere with absorption timing
Citation: Mosby’s, Omeprazole
3.
A patient on long-term omeprazole therapy is at risk for which
complication?
A. Hypercalcemia
B. Vitamin B12 deficiency
C. Increased platelet count
D. Hypoglycemia
Answer: B
Rationale:
Long-term PPI use can lead to vitamin B12 deficiency due to
decreased gastric acidity.
Citation: Mosby’s, Omeprazole
4.
The nurse is monitoring a patient taking famotidine. Which
outcome indicates effectiveness?
, A. Decreased nausea
B. Reduced gastric acidity
C. Increased bowel motility
D. Improved appetite
Answer: B
Rationale:
Famotidine is an H2 receptor antagonist that reduces gastric
acid secretion.
Citation: Mosby’s, Famotidine
5.
Which adverse effect should the nurse monitor in a patient
receiving famotidine?
A. Hypertension
B. Confusion (especially in older adults)
C. Severe hypoglycemia
D. Bradycardia
Answer: B
Rationale:
Famotidine may cause confusion, particularly in elderly
patients.
Citation: Mosby’s, Famotidine
2nd Edition
Authors :
Linda Skidmore-Roth & Faith Richardson
NCLEX-Style MCQs based strictly on
Mosby’s Canadian Nursing Drug Reference,
2nd Edition for the specified
Gastrointestinal Drugs.
1.
A nurse is administering omeprazole for GERD. What is the
primary mechanism of action?
A. Neutralizes gastric acid
B. Blocks histamine receptors in the stomach
,C. Inhibits the proton pump in gastric parietal cells
D. Coats the gastric mucosa
Answer: C
Rationale:
Omeprazole is a proton pump inhibitor (PPI) that suppresses
gastric acid secretion by inhibiting the H⁺/K⁺ ATPase pump in
parietal cells.
• A: Antacids
• B: H2 blockers (famotidine)
• D: Sucralfate
Citation: Mosby’s Canadian Nursing Drug Reference (2nd ed.),
Omeprazole
2.
Which instruction should the nurse give a patient taking
omeprazole?
A. Take with antacids
B. Take before meals
C. Crush the tablet before taking
D. Take at bedtime only
Answer: B
,Rationale:
Omeprazole should be taken before meals, typically in the
morning, for optimal acid suppression.
• C: Enteric-coated—do not crush
• A: May interfere with absorption timing
Citation: Mosby’s, Omeprazole
3.
A patient on long-term omeprazole therapy is at risk for which
complication?
A. Hypercalcemia
B. Vitamin B12 deficiency
C. Increased platelet count
D. Hypoglycemia
Answer: B
Rationale:
Long-term PPI use can lead to vitamin B12 deficiency due to
decreased gastric acidity.
Citation: Mosby’s, Omeprazole
4.
The nurse is monitoring a patient taking famotidine. Which
outcome indicates effectiveness?
, A. Decreased nausea
B. Reduced gastric acidity
C. Increased bowel motility
D. Improved appetite
Answer: B
Rationale:
Famotidine is an H2 receptor antagonist that reduces gastric
acid secretion.
Citation: Mosby’s, Famotidine
5.
Which adverse effect should the nurse monitor in a patient
receiving famotidine?
A. Hypertension
B. Confusion (especially in older adults)
C. Severe hypoglycemia
D. Bradycardia
Answer: B
Rationale:
Famotidine may cause confusion, particularly in elderly
patients.
Citation: Mosby’s, Famotidine
