QUESTIONS AND SOLUTIONS ALREADY
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⩥ Early menopause. Answer: LMP before age 45.
⩥ Late menopause. Answer: LMP after age 54.
⩥ Primary ovarian insufficiency. Answer: Menopause that occurs before
age 40.
⩥ Early menopause transition (stage -2). Answer: Persistent difference
of 7 days or more in the length of consecutive cycles.
⩥ Late menopause transition (stage -1). Answer: 60 or more consecutive
days of amenorrhea.
⩥ Luteal out of phase event (LOOP). Answer: Explains why some
perimenopausal women have elevated estrogen levels sometimes.
⩥ Obese women and estradiol levels during menopause. Answer: Obese
women are more likely to have anovulatory cycles with high estradiol
levels.
,⩥ Chinese and Japanese women. Answer: These ethnic groups have
lower estradiol levels than white, black, and Hispanic women.
⩥ Stage +2. Answer: Late menopause stage: 5-8 years after FMP.
Somatic aging predominates.
⩥ Stages +1a, +1b, +1c. Answer: Early post menopause: 2 years after
FMP. FSH rises, estradiol decreases.
⩥ Elevated FSH, LH. Answer: Endocrine labs after menopause.
⩥ AMH, inhibin B. Answer: These hormones work during reproductive
years to not deplete follicle pool too quickly.
⩥ Phases during menopause transition and PMS symptoms. Answer:
Menstrual cycle variable, persistent >7 day difference between
difference in length of consecutive cycles.
⩥ How to respond if a patient requests FSH lab?. Answer: Many pitfalls,
variable depending on the day of the cycle you draw the lab.
⩥ The potentially superior marker of menopause, a lab.. Answer: AMH.
,⩥ DHEA (dehydroepiandrosterone). Answer: Adrenal androgens:
precursor hormones produced by the adrenal gland that are
enzymatically converted to active androgens or estrogens in peripheral
tissues.
⩥ Location of estrogen receptors. Answer: Vagina, vulva, urethra,
trigone of the bladder.
⩥ Effects of estrogen on tissue. Answer: Maintain blood flow, the
collagen, and HA within the epithelial surfaces.
⩥ Vaginal changes with menopause. Answer: Thinning, loss of elasticity,
loss or absence of rugae.
⩥ Vagina and urethra in menopause. Answer: Vagina narrows, urethra
moves closer to the introitus.
⩥ Stress urinary incontinence. Answer: Vaginal estrogen and urinary
incontinence: what type does it help with?
⩥ Treatment for FPHL. Answer: Minoxidil, spironolactone, finasteride,
estrogen therapy.
, ⩥ Late reproductive years -3b and -3a. Answer: -3b: menstrual cycles
normal, FSH normal, AMH low, AFC low, inhibin low. -3a: subtle
menstrual changes, variable FSH, AMH low, AFC low, inhibin low.
⩥ When it is appropriate to check an FSH during the cycle if you check
it?. Answer: Cycle day #3. Elevated estradiol can suppress FSH giving a
falsely normal FSH level.
⩥ AFC. Answer: Antral follicle count. Number of follicles that are
detectable with ultrasound.
⩥ Late menopause transition (-1) FSH level on random draw. Answer:
25 or higher.
⩥ Black women have higher or lower FSH levels?. Answer: Higher.
⩥ Chinese and Japanese women have higher or lower estradiol levels
compared to white, black and Hispanic women?. Answer: Lower.
⩥ Menopause transition-changes in SHBG and testosterone?. Answer:
SHBG decreases. Testosterone/SHBG ratio increases by 80%.
⩥ Testosterone/SHBG ratio is called what?. Answer: The free androgen
index.