Pharmacotherapy Added Qualifications
Exam – Psychiatry Verified Questions,
Correct Answers, and Detailed
Explanations for Science
Students||Already Graded A+
1. Which antidepressant is most strongly associated with
anticholinergic adverse effects?
A. Sertraline
B. Venlafaxine
C. Amitriptyline
D. Bupropion
Answer: C
Tricyclic antidepressants such as amitriptyline have significant
anticholinergic, antihistaminic, and alpha-blocking effects.
2. A patient with bipolar I disorder presents with acute mania.
Which medication is first-line?
A. Fluoxetine
B. Lithium
C. Lamotrigine
D. Sertraline
Answer: B
Lithium is a first-line mood stabilizer for acute mania and
maintenance in bipolar I disorder.
3. Which antidepressant has the lowest risk of sexual dysfunction?
,A. Paroxetine
B. Fluoxetine
C. Bupropion
D. Sertraline
Answer: C
Bupropion lacks serotonergic activity and is associated with minimal
sexual side effects.
4. Clozapine therapy requires monitoring primarily due to risk of:
A. QT prolongation
B. Tardive dyskinesia
C. Agranulocytosis
D. Hyperprolactinemia
Answer: C
Clozapine carries a boxed warning for agranulocytosis, requiring
routine ANC monitoring.
5. Which antipsychotic is most associated with hyperprolactinemia?
A. Quetiapine
B. Olanzapine
C. Risperidone
D. Clozapine
Answer: C
Risperidone strongly antagonizes dopamine D₂ receptors, increasing
prolactin levels.
6. First-line pharmacotherapy for generalized anxiety disorder
(GAD) includes:
,A. Haloperidol
B. SSRIs
C. Tricyclic antidepressants
D. MAOIs
Answer: B
SSRIs and SNRIs are first-line treatments for GAD due to efficacy and
tolerability.
7. Which medication is FDA-approved for treatment-resistant
depression as an intranasal product?
A. Ketamine
B. Esketamine
C. Lamotrigine
D. Quetiapine
Answer: B
Esketamine nasal spray is FDA-approved for treatment-resistant
depression.
8. Which mood stabilizer is most appropriate for bipolar
depression?
A. Valproate
B. Carbamazepine
C. Lamotrigine
D. Haloperidol
Answer: C
Lamotrigine is effective for bipolar depression and maintenance but
not acute mania.
, 9. A patient on MAOIs consumes aged cheese and develops severe
hypertension. This is due to:
A. Serotonin syndrome
B. Neuroleptic malignant syndrome
C. Tyramine reaction
D. Anticholinergic toxicity
Answer: C
Tyramine causes excessive norepinephrine release when MAO is
inhibited.
10. Which antipsychotic has the lowest risk of metabolic syndrome?
A. Olanzapine
B. Clozapine
C. Aripiprazole
D. Quetiapine
Answer: C
Aripiprazole is relatively weight-neutral compared to other second-
generation antipsychotics.
11. Which medication is first-line for obsessive-compulsive disorder
(OCD)?
A. Bupropion
B. Fluoxetine
C. Mirtazapine
D. Buspirone
Answer: B
SSRIs at higher doses are first-line for OCD.
Exam – Psychiatry Verified Questions,
Correct Answers, and Detailed
Explanations for Science
Students||Already Graded A+
1. Which antidepressant is most strongly associated with
anticholinergic adverse effects?
A. Sertraline
B. Venlafaxine
C. Amitriptyline
D. Bupropion
Answer: C
Tricyclic antidepressants such as amitriptyline have significant
anticholinergic, antihistaminic, and alpha-blocking effects.
2. A patient with bipolar I disorder presents with acute mania.
Which medication is first-line?
A. Fluoxetine
B. Lithium
C. Lamotrigine
D. Sertraline
Answer: B
Lithium is a first-line mood stabilizer for acute mania and
maintenance in bipolar I disorder.
3. Which antidepressant has the lowest risk of sexual dysfunction?
,A. Paroxetine
B. Fluoxetine
C. Bupropion
D. Sertraline
Answer: C
Bupropion lacks serotonergic activity and is associated with minimal
sexual side effects.
4. Clozapine therapy requires monitoring primarily due to risk of:
A. QT prolongation
B. Tardive dyskinesia
C. Agranulocytosis
D. Hyperprolactinemia
Answer: C
Clozapine carries a boxed warning for agranulocytosis, requiring
routine ANC monitoring.
5. Which antipsychotic is most associated with hyperprolactinemia?
A. Quetiapine
B. Olanzapine
C. Risperidone
D. Clozapine
Answer: C
Risperidone strongly antagonizes dopamine D₂ receptors, increasing
prolactin levels.
6. First-line pharmacotherapy for generalized anxiety disorder
(GAD) includes:
,A. Haloperidol
B. SSRIs
C. Tricyclic antidepressants
D. MAOIs
Answer: B
SSRIs and SNRIs are first-line treatments for GAD due to efficacy and
tolerability.
7. Which medication is FDA-approved for treatment-resistant
depression as an intranasal product?
A. Ketamine
B. Esketamine
C. Lamotrigine
D. Quetiapine
Answer: B
Esketamine nasal spray is FDA-approved for treatment-resistant
depression.
8. Which mood stabilizer is most appropriate for bipolar
depression?
A. Valproate
B. Carbamazepine
C. Lamotrigine
D. Haloperidol
Answer: C
Lamotrigine is effective for bipolar depression and maintenance but
not acute mania.
, 9. A patient on MAOIs consumes aged cheese and develops severe
hypertension. This is due to:
A. Serotonin syndrome
B. Neuroleptic malignant syndrome
C. Tyramine reaction
D. Anticholinergic toxicity
Answer: C
Tyramine causes excessive norepinephrine release when MAO is
inhibited.
10. Which antipsychotic has the lowest risk of metabolic syndrome?
A. Olanzapine
B. Clozapine
C. Aripiprazole
D. Quetiapine
Answer: C
Aripiprazole is relatively weight-neutral compared to other second-
generation antipsychotics.
11. Which medication is first-line for obsessive-compulsive disorder
(OCD)?
A. Bupropion
B. Fluoxetine
C. Mirtazapine
D. Buspirone
Answer: B
SSRIs at higher doses are first-line for OCD.
