ACOG Practice Bulletin Questions and
Answers (100% Correct Answers) Already
Graded A+
True or False: Pretest and post- test counseling are
essential and must be a part of any screening program.— [
Ans: ] True
What is aneuploidy?— [ Ans: ] Having one or more extra
chromosomes
How common are chromosomal abnormalities in live
births?— [ Ans: ] 1/150 live births are affected with a
chromosome abnormality
Name three factors that increase the chance for a
chromosome abnormality— [ Ans: ] 1. Maternal Age
2. Previous pregnancy affected with a chromosome
abnormality
3. Ultrasound abnormalities
Do ACOG practice guidelines dictate an exclusive course
of treatment?— [ Ans: ] No
The information is designed to aid practitioners in making
decisions about appropriate obstetric and gynecologic
care. Variations in practice may be warranted based on the
needs of the individual patient, resources, and limitations
unique to the institution or type of practice.
,What is the most common autosomal trisomy?— [ Ans: ]
Trisomy 21 (Down syndrome)
What is the most common sex chromosome
abnormality?— [ Ans: ] 47, XXY Klinefelter syndrome
How common is Klinefelter syndrome?— [ Ans: ] 1/500
males are affected or 1/1,000 births
What is the only viable monosomy?— [ Ans: ] Turner
syndrome (45, X)
What percentage of cases of Down syndrome are caused
by non-disjunction?— [ Ans: ] 95%
What is the median survival of individuals affected with
Down syndrome in economically developed countries?— [
Ans: ] Approximately 60 years of age
What percentage of pregnancies affected with Down
syndrome end in miscarriage or stillbirth?— [ Ans: ] 43%
Does ACOG discourage women who have a negative
screening test for aneuploidy from having a procedure
such as amnio or CVS so that diagnostic testing such as
microarray or chromosome analysis can be performed— [
Ans: ] No, even if a woman has had negative aneuploidy
screening ACOG supports the option of diagnostic testing
should that patient want it
Who does ACOG recommend should be offered the option
of diagnostic testing as well as aneuploidy screening and
, when?— [ Ans: ] All women regardless of their age should
be offered screening and diagnostic testing early in
pregnancy
What percentage of pregnancies affected with Down
syndrome occur in women 35 or older at the time of
delivery?— [ Ans: ] Approximately 22% (21.6%)
What is nondisjunction?— [ Ans: ] Nondisjunction is the
failure of homologous chromosomes or sister chromatids
to separate subsequent to metaphase in meiosis or mitosis
so that one daughter cell has both and the other neither of
the chromosomes.
When a positive or abnormal screening test result occurs
the patient should be counseled regarding the adjusted
likelihood or probability of carrying a fetus with the
aneuploidy the pregnancy is at an increased chance for.—
[ Ans: ] True
When a negative screening test result is obtained (low
risk), the patient should simply be told that they are at a
low chance to have a fetus affected with a chromosome
abnormality.— [ Ans: ] False. It is recommended that
patient's with both high and low risk results be given the
probability for aneuploidy if it can be estimated.
Name one thing that should be discussed regarding the
limitations of aneuploidy screening.— [ Ans: ] The
potential for the fetus to be affected by a genetic disorder
or abnormality that is not evaluated by the screening or
diagnostic tests being offered.
Answers (100% Correct Answers) Already
Graded A+
True or False: Pretest and post- test counseling are
essential and must be a part of any screening program.— [
Ans: ] True
What is aneuploidy?— [ Ans: ] Having one or more extra
chromosomes
How common are chromosomal abnormalities in live
births?— [ Ans: ] 1/150 live births are affected with a
chromosome abnormality
Name three factors that increase the chance for a
chromosome abnormality— [ Ans: ] 1. Maternal Age
2. Previous pregnancy affected with a chromosome
abnormality
3. Ultrasound abnormalities
Do ACOG practice guidelines dictate an exclusive course
of treatment?— [ Ans: ] No
The information is designed to aid practitioners in making
decisions about appropriate obstetric and gynecologic
care. Variations in practice may be warranted based on the
needs of the individual patient, resources, and limitations
unique to the institution or type of practice.
,What is the most common autosomal trisomy?— [ Ans: ]
Trisomy 21 (Down syndrome)
What is the most common sex chromosome
abnormality?— [ Ans: ] 47, XXY Klinefelter syndrome
How common is Klinefelter syndrome?— [ Ans: ] 1/500
males are affected or 1/1,000 births
What is the only viable monosomy?— [ Ans: ] Turner
syndrome (45, X)
What percentage of cases of Down syndrome are caused
by non-disjunction?— [ Ans: ] 95%
What is the median survival of individuals affected with
Down syndrome in economically developed countries?— [
Ans: ] Approximately 60 years of age
What percentage of pregnancies affected with Down
syndrome end in miscarriage or stillbirth?— [ Ans: ] 43%
Does ACOG discourage women who have a negative
screening test for aneuploidy from having a procedure
such as amnio or CVS so that diagnostic testing such as
microarray or chromosome analysis can be performed— [
Ans: ] No, even if a woman has had negative aneuploidy
screening ACOG supports the option of diagnostic testing
should that patient want it
Who does ACOG recommend should be offered the option
of diagnostic testing as well as aneuploidy screening and
, when?— [ Ans: ] All women regardless of their age should
be offered screening and diagnostic testing early in
pregnancy
What percentage of pregnancies affected with Down
syndrome occur in women 35 or older at the time of
delivery?— [ Ans: ] Approximately 22% (21.6%)
What is nondisjunction?— [ Ans: ] Nondisjunction is the
failure of homologous chromosomes or sister chromatids
to separate subsequent to metaphase in meiosis or mitosis
so that one daughter cell has both and the other neither of
the chromosomes.
When a positive or abnormal screening test result occurs
the patient should be counseled regarding the adjusted
likelihood or probability of carrying a fetus with the
aneuploidy the pregnancy is at an increased chance for.—
[ Ans: ] True
When a negative screening test result is obtained (low
risk), the patient should simply be told that they are at a
low chance to have a fetus affected with a chromosome
abnormality.— [ Ans: ] False. It is recommended that
patient's with both high and low risk results be given the
probability for aneuploidy if it can be estimated.
Name one thing that should be discussed regarding the
limitations of aneuploidy screening.— [ Ans: ] The
potential for the fetus to be affected by a genetic disorder
or abnormality that is not evaluated by the screening or
diagnostic tests being offered.
