AEBP Quiz 4 questions with verified
answers rated A+
Hypothetical investigators report development of a new clinical prediction rule to determine the
need for nerve conduction velocity testing in cases of acute sensory loss. They indicate the
clinicians evaluating subjects were unaware of their actual status with respect to integrity of the
affected nerves.
Why does this design feature enhance the quality of the study?
Presence of co-morbidities was unlikely to undermine the rule's accuracy
Clinician bias due to prior knowledge was unlikely to undermine the rule's accuracy
Nerve conduction velocity performance was unlikely to undermine the rule's accuracy
Subject knowledge of their status was unlikely to undermine the rule's accuaracy - correct
answer ✔✔Clinician bias due to prior knowledge was unlikely to undermine the rule's accuracy
The investigators in the nerve conduction velocity study provided the following 2 x 2 table
relating the outcome of the rule with presence or absence of nerve injury.
Calculate the negative likelihood ratio from this table.
0.39
3.77
0.82
0.68 - correct answer ✔✔0.39
Interpret the negative likelihood ratio obtained for the clinical prediction rule (CPR) in the
previous question.
The likelihood that a nerve injury is present in a subject who was cleared by the CPR is increased
by a moderate amount
, The likelihood that a nerve injury is present in a subject who was cleared by the CPR is
decreased by a moderate small amount
The likelihood that a nerve injury is present in a subject who was cleared by the CPR is increased
by a small but potentially important amount.
The likelihood that a nerve injury is present in a subject who was cleared by the CPR is
decreased by a small but potentially important amount - correct answer ✔✔The likelihood that
a nerve injury is present in a subject who was cleared by the CPR is decreased by a small but
potentially important amount
Which of the following statements most accurately characterizes the need to operationally
define predictive factors during development of a new clinical prediction rule?
The need to identify which subjects actually have predictive factors
The need to identify factors that are clinically meaningful
The need to associate predictive factors with the outcome of interest
The need to select enough factors for predictive accuracy - correct answer ✔✔The need to
identify which subjects actually have predictive factors
A hypothetical study describes the derivation of a new clinical prediction rule to determine
which individuals with multiple sclerosis will respond best to physical therapy.
Which of the following statements most accurately characterizes this situation?
Derivation of the rule is necessary after it has been validated
Derivation of the rule does not guarantee its validity in practice
Validation of the rule is unnecessary if a large enough sample size is used
Validation of the rule is only needed if it is applied to a new population - correct answer
✔✔Derivation of the rule does not guarantee its validity in practice
Which of the following statistical methods is commonly used in the process of creating a new
clinical prediction rule?
Calculation of effect size to determine the magnitude of predictive factors
answers rated A+
Hypothetical investigators report development of a new clinical prediction rule to determine the
need for nerve conduction velocity testing in cases of acute sensory loss. They indicate the
clinicians evaluating subjects were unaware of their actual status with respect to integrity of the
affected nerves.
Why does this design feature enhance the quality of the study?
Presence of co-morbidities was unlikely to undermine the rule's accuracy
Clinician bias due to prior knowledge was unlikely to undermine the rule's accuracy
Nerve conduction velocity performance was unlikely to undermine the rule's accuracy
Subject knowledge of their status was unlikely to undermine the rule's accuaracy - correct
answer ✔✔Clinician bias due to prior knowledge was unlikely to undermine the rule's accuracy
The investigators in the nerve conduction velocity study provided the following 2 x 2 table
relating the outcome of the rule with presence or absence of nerve injury.
Calculate the negative likelihood ratio from this table.
0.39
3.77
0.82
0.68 - correct answer ✔✔0.39
Interpret the negative likelihood ratio obtained for the clinical prediction rule (CPR) in the
previous question.
The likelihood that a nerve injury is present in a subject who was cleared by the CPR is increased
by a moderate amount
, The likelihood that a nerve injury is present in a subject who was cleared by the CPR is
decreased by a moderate small amount
The likelihood that a nerve injury is present in a subject who was cleared by the CPR is increased
by a small but potentially important amount.
The likelihood that a nerve injury is present in a subject who was cleared by the CPR is
decreased by a small but potentially important amount - correct answer ✔✔The likelihood that
a nerve injury is present in a subject who was cleared by the CPR is decreased by a small but
potentially important amount
Which of the following statements most accurately characterizes the need to operationally
define predictive factors during development of a new clinical prediction rule?
The need to identify which subjects actually have predictive factors
The need to identify factors that are clinically meaningful
The need to associate predictive factors with the outcome of interest
The need to select enough factors for predictive accuracy - correct answer ✔✔The need to
identify which subjects actually have predictive factors
A hypothetical study describes the derivation of a new clinical prediction rule to determine
which individuals with multiple sclerosis will respond best to physical therapy.
Which of the following statements most accurately characterizes this situation?
Derivation of the rule is necessary after it has been validated
Derivation of the rule does not guarantee its validity in practice
Validation of the rule is unnecessary if a large enough sample size is used
Validation of the rule is only needed if it is applied to a new population - correct answer
✔✔Derivation of the rule does not guarantee its validity in practice
Which of the following statistical methods is commonly used in the process of creating a new
clinical prediction rule?
Calculation of effect size to determine the magnitude of predictive factors
