1 | Page
RXRS 407 Week 10 Questions and Correct
Answers
blueprint for drug product design Ans: - physiological
considerations: pH, food, disease state
- physiochemical property considerations: thermodynamics and
kinetics
- pharmacological TAP considerations: safety and efficacy
- patient demographic: pediatric, alzheimer, geriatric
pharmacological TAP considerations Ans: - identify and
understand the pk and of needs for efficacy and safety
- target modulation, desired effects, time course, threshold,
selectivity, location
- Ceff: what is desired for efficacy
isoform Ans: same protein expressed in different locations
target modulation general terms Ans: agonist, antagonist,
allosteric, enzyme targets, receptor based targets
target modulation desired effects Ans: - understand if its
activation or inhibition
© 2025 All rights reserved
, 2 | Page
- desired effect? cascade of steps?
target modulation: time course Ans: - AUC?
- Cplasma
- Cfree: protein binding to achieve desired efficacy
- duration above Ceff
target modulation: threshold Ans: - could target modulation be
influenced by Cmax
- above IC50 or IC90?
- selectivity of molecule for target?
target modulation: selectivity Ans: - relationship of Ceff and
safety, potential mechanism related toxicities
target modulation: location Ans: - site of pharmacological action,
primary location of target: organ, tissue, cell surface
ketamine pk Ans: - antagonist, surge in glutamate release, exact
mechanism of antidepressant action is under debate
depression study Ans: - FST and TST manipulated mice
- physical stresses 1-6 weeks
© 2025 All rights reserved
RXRS 407 Week 10 Questions and Correct
Answers
blueprint for drug product design Ans: - physiological
considerations: pH, food, disease state
- physiochemical property considerations: thermodynamics and
kinetics
- pharmacological TAP considerations: safety and efficacy
- patient demographic: pediatric, alzheimer, geriatric
pharmacological TAP considerations Ans: - identify and
understand the pk and of needs for efficacy and safety
- target modulation, desired effects, time course, threshold,
selectivity, location
- Ceff: what is desired for efficacy
isoform Ans: same protein expressed in different locations
target modulation general terms Ans: agonist, antagonist,
allosteric, enzyme targets, receptor based targets
target modulation desired effects Ans: - understand if its
activation or inhibition
© 2025 All rights reserved
, 2 | Page
- desired effect? cascade of steps?
target modulation: time course Ans: - AUC?
- Cplasma
- Cfree: protein binding to achieve desired efficacy
- duration above Ceff
target modulation: threshold Ans: - could target modulation be
influenced by Cmax
- above IC50 or IC90?
- selectivity of molecule for target?
target modulation: selectivity Ans: - relationship of Ceff and
safety, potential mechanism related toxicities
target modulation: location Ans: - site of pharmacological action,
primary location of target: organ, tissue, cell surface
ketamine pk Ans: - antagonist, surge in glutamate release, exact
mechanism of antidepressant action is under debate
depression study Ans: - FST and TST manipulated mice
- physical stresses 1-6 weeks
© 2025 All rights reserved
