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BIO 322 Pathophysiology Midterm Exam
2025 – Comprehensive Study Guide, Practice
Questions & Answer Key
Prepare for your BIO 322 Pathophysiology Midterm Exam with this complete 2025 study
guide covering disease mechanisms, inflammation, immune response, cellular injury, and
system disorders. Includes practice questions, answers, and detailed rationales to help you
master every concept.
BIO 322 Patho Midterm Exam,
BIO 322 Pathophysiology exam,
Pathophysiology midterm study guide,
The "weakness" first appeared in Queen Victoria's family in her eighth child, Prince Leopold, Duke of
Albany. Throughout his short life, Leopold had suffered severe hemorrhages, and always was described
as "very delicate". Leading the life of a normal child was impossible for Leopold because any cut or
bump could lead to death and it was necessary to keep him always under strict surveillance. However, in
spite of all the protection, Prince Leopold died at the age of thirty one as the result of a minor fall.
Assuming that this is NOT Von Willebrand's, who is most likely to develop this similar fate?
A. All of Leopold's children
B. Leopold's daughters
C. Leopold's sons
D. Leopold's grandsons - ANSWER-A and D
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Which of the following is a common feature of all types of shock?
A. Atherosclerosis
B. Hypertension
C. Increase in cardiac output
D. Hypotension - ANSWER-D
Mason is a 44-year-old male who presents with melena and persisting epigastric pain. Clinical history
reveals that he is a smoker and a weekend binge drinker. Lab tests show slight leukocytosis, normal
Amylase and Lipase enzymes, normal bilirubin, AST and ALT. Physical exam is negative for abdominal
rebound tenderness and a breath test is positive for H. Pylori. What is the probable cause of Mason's
symptoms?
A. Pancreatitis
B. Petic Ulcer
C. Liver cirrhosis
D. Appendicitis - ANSWER-D
Which are true of a deficiency of intrinsic factor? It can cause.....
A. pernicious anemia
B. aplastic anemia
C. low mean cell volume
D. gastric atrophy
E. lower than normal MCH - ANSWER-B,C, and D
Which of the following matches the following description: Occurs in the heart, kidneys, and adrenal
glands; results from ischemia and subsequent hypoxia; results in protein denaturation
A. Liquefactive necrosis
B. Coagulative necrosis
C. Caseous necrosis
D. Fat necrosis
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E. Gangrenous necrosis - ANSWER-A
Ingrid, a 35-year-old female with severe osteoarthritis, is taking big doses of aspirin (salicylates). To
prevent mucosa gastric damage, she decided to ingest high doses of antacids. One day, she shows
weakness, cramps, and confusion. You order ABG's that show an anion gap of 17. Which of the following
do you specifically expect to find?
A. Metabolic acidosis with high anion gap
B. Compensated Respiratory acidosis
C. Metabolic alkalosis with normal anion gap
D. Metabolic alkalosis with high anion gap - ANSWER-B
A 30-year-old male woman recently gave birth to her first child via Caesarean section. She was taken to
the hospital after complaints of skin rash around the site of her Caesarean section wound and she also
complained of "something oozing from the scar." A nurse took her back, took her vital signs and found
her BP to be extremely low: 100/60. After speaking with the doctor on call, he decides to order further
testing and found her CBC to contain the following: low fibrinogen levels, low antithrombin and a low
platelet count among other things, Based on these results, an initial diagnosis od sepsis is given. The
doctor didn't feel this was enough so he performed a more thorough exam and found remnants of her
placenta that was left in her abdominal cavity from her Caesarean section. If left untreated, what might
be the next sing/symptom to develop?
A. shock from dehydration
B. massive bleeding
C. severe headache
D. Vo - ANSWER-B
Drake has been suffering from severe heartburn for years. Sometimes the over the counter medications
helps, but lately he has found that he to sleep in his chair in the living room because his chest pain is
worse at night. He is also on a heavy dose of proton pump inhibitors to try to help alleviate the
symptoms. If this continues, what physiological cell changes might Drake be concerned about?
A. Hyperplasia of stomach mucosa
B. Hypertrophic changes to epiglottis
C. Metaplasia in esophagus
D. Dysphagia to Lower Esophageal Sphicnter - ANSWER-B
BIO 322 Pathophysiology Midterm Exam
2025 – Comprehensive Study Guide, Practice
Questions & Answer Key
Prepare for your BIO 322 Pathophysiology Midterm Exam with this complete 2025 study
guide covering disease mechanisms, inflammation, immune response, cellular injury, and
system disorders. Includes practice questions, answers, and detailed rationales to help you
master every concept.
BIO 322 Patho Midterm Exam,
BIO 322 Pathophysiology exam,
Pathophysiology midterm study guide,
The "weakness" first appeared in Queen Victoria's family in her eighth child, Prince Leopold, Duke of
Albany. Throughout his short life, Leopold had suffered severe hemorrhages, and always was described
as "very delicate". Leading the life of a normal child was impossible for Leopold because any cut or
bump could lead to death and it was necessary to keep him always under strict surveillance. However, in
spite of all the protection, Prince Leopold died at the age of thirty one as the result of a minor fall.
Assuming that this is NOT Von Willebrand's, who is most likely to develop this similar fate?
A. All of Leopold's children
B. Leopold's daughters
C. Leopold's sons
D. Leopold's grandsons - ANSWER-A and D
,2|Page
Which of the following is a common feature of all types of shock?
A. Atherosclerosis
B. Hypertension
C. Increase in cardiac output
D. Hypotension - ANSWER-D
Mason is a 44-year-old male who presents with melena and persisting epigastric pain. Clinical history
reveals that he is a smoker and a weekend binge drinker. Lab tests show slight leukocytosis, normal
Amylase and Lipase enzymes, normal bilirubin, AST and ALT. Physical exam is negative for abdominal
rebound tenderness and a breath test is positive for H. Pylori. What is the probable cause of Mason's
symptoms?
A. Pancreatitis
B. Petic Ulcer
C. Liver cirrhosis
D. Appendicitis - ANSWER-D
Which are true of a deficiency of intrinsic factor? It can cause.....
A. pernicious anemia
B. aplastic anemia
C. low mean cell volume
D. gastric atrophy
E. lower than normal MCH - ANSWER-B,C, and D
Which of the following matches the following description: Occurs in the heart, kidneys, and adrenal
glands; results from ischemia and subsequent hypoxia; results in protein denaturation
A. Liquefactive necrosis
B. Coagulative necrosis
C. Caseous necrosis
D. Fat necrosis
, 3|Page
E. Gangrenous necrosis - ANSWER-A
Ingrid, a 35-year-old female with severe osteoarthritis, is taking big doses of aspirin (salicylates). To
prevent mucosa gastric damage, she decided to ingest high doses of antacids. One day, she shows
weakness, cramps, and confusion. You order ABG's that show an anion gap of 17. Which of the following
do you specifically expect to find?
A. Metabolic acidosis with high anion gap
B. Compensated Respiratory acidosis
C. Metabolic alkalosis with normal anion gap
D. Metabolic alkalosis with high anion gap - ANSWER-B
A 30-year-old male woman recently gave birth to her first child via Caesarean section. She was taken to
the hospital after complaints of skin rash around the site of her Caesarean section wound and she also
complained of "something oozing from the scar." A nurse took her back, took her vital signs and found
her BP to be extremely low: 100/60. After speaking with the doctor on call, he decides to order further
testing and found her CBC to contain the following: low fibrinogen levels, low antithrombin and a low
platelet count among other things, Based on these results, an initial diagnosis od sepsis is given. The
doctor didn't feel this was enough so he performed a more thorough exam and found remnants of her
placenta that was left in her abdominal cavity from her Caesarean section. If left untreated, what might
be the next sing/symptom to develop?
A. shock from dehydration
B. massive bleeding
C. severe headache
D. Vo - ANSWER-B
Drake has been suffering from severe heartburn for years. Sometimes the over the counter medications
helps, but lately he has found that he to sleep in his chair in the living room because his chest pain is
worse at night. He is also on a heavy dose of proton pump inhibitors to try to help alleviate the
symptoms. If this continues, what physiological cell changes might Drake be concerned about?
A. Hyperplasia of stomach mucosa
B. Hypertrophic changes to epiglottis
C. Metaplasia in esophagus
D. Dysphagia to Lower Esophageal Sphicnter - ANSWER-B
