EKU NSC 830 ADV PHARM QUESTIONS & ANSWERS
Distribution - Answer -Drug movement from the blood to tissues and cells
What is Distribution Affected by? - Answer -Protein binding, blood flow to the tissues,
ability of the drug to exit the vascular space, and the ability of the drug to enter the cell
What do most drugs bind with - Answer -plasma protein - albumin
What does plasma protein albumin do after binding w drugs - Answer -acts as a carrier
Bound drug molecules are considered - Answer -inactive
Unbound/Free drug molecules are considered - Answer -active
What portion of the drug acts on body cells - Answer -the free or unbound portion
If a drug molecules is bound to plasma protein, why is it considered inactive? - Answer
-It is too big to cross over into the tissues from the plasma
In order for drugs to cross the Blood Brain Barrier they must be: - Answer -Un-ionized,
small molecules, and lipid soluable
in order for drugs to pass the placental barrier they must be: - Answer -Lipid soluable,
smaller molecule drugs, and there must be passive diffusion
Metabolism - Answer -the process of chemically changing a drug to a different
compound called a metabolite
What are active drugs changed into in order to be excreted? - Answer -one or more
inactive metabolites
A function of Metabolism: - Answer -Changing from an active metabolite to an inactive
metabolite OR changing from an inactive metabolite to an active metabolite.
If a drug is administered as an inactive pro-drug what must happen for the drug to have
an effect? - Answer -The drug must be metabolized to an active metabolite from the
inactive pro-drug state to have an effect
What must happen to drugs in order to be excreted by the kidneys? - Answer -they
must be converted from lipid soluble to water soluble metabolites
What is the main site of drug metabolism? - Answer -The liver
Distribution - Answer -Drug movement from the blood to tissues and cells
What is Distribution Affected by? - Answer -Protein binding, blood flow to the tissues,
ability of the drug to exit the vascular space, and the ability of the drug to enter the cell
What do most drugs bind with - Answer -plasma protein - albumin
What does plasma protein albumin do after binding w drugs - Answer -acts as a carrier
Bound drug molecules are considered - Answer -inactive
Unbound/Free drug molecules are considered - Answer -active
What portion of the drug acts on body cells - Answer -the free or unbound portion
If a drug molecules is bound to plasma protein, why is it considered inactive? - Answer
-It is too big to cross over into the tissues from the plasma
In order for drugs to cross the Blood Brain Barrier they must be: - Answer -Un-ionized,
small molecules, and lipid soluable
in order for drugs to pass the placental barrier they must be: - Answer -Lipid soluable,
smaller molecule drugs, and there must be passive diffusion
Metabolism - Answer -the process of chemically changing a drug to a different
compound called a metabolite
What are active drugs changed into in order to be excreted? - Answer -one or more
inactive metabolites
A function of Metabolism: - Answer -Changing from an active metabolite to an inactive
metabolite OR changing from an inactive metabolite to an active metabolite.
If a drug is administered as an inactive pro-drug what must happen for the drug to have
an effect? - Answer -The drug must be metabolized to an active metabolite from the
inactive pro-drug state to have an effect
What must happen to drugs in order to be excreted by the kidneys? - Answer -they
must be converted from lipid soluble to water soluble metabolites
What is the main site of drug metabolism? - Answer -The liver
