MMSC 433 Exam 3 Questions and Answers Latest Update 2025-2026
Why is Rouleaux formation associated with Multiple Myeloma and Waldenstrom's
macroglobulinemia?
A. abnormal proteins secreted from megakaryocytes coat red blood cells causing them to
appear stacked on the peripheral blood smear
B. abnormal proteins produced from T lymphocytes coat red blood cells causing them to
appear stacked on the peripheral blood smear
C. abnormal proteins produced from segmented neutrophils coat red blood cells causing them
to appear stacked on the peripheral blood smear
D. abnormal proteins produced from myeloma cells coat red blood cells causing them to
appear stacked on the peripheral blood smear - Answers abnormal proteins produced from
myeloma cells coat red blood cells causing them to appear stacked on the peripheral blood
smear
A "dry tap" bone marrow aspiration may be seen with what chronic myeloid proliferative disease?
A. Essential Thrombocythemia
B. Polycythemia Vera
C. Primary Myelofibrosis
D. Chronic Myeloid Leukemia - Answers Primary Myelofibrosis
What clinical feature is more often associated with essential thrombocythemia than with the
other chronic myeloproliferative disorders?
A. bleeding and thrombosis
B. infections
C. splenomegaly
D. fatigue - Answers bleeding and thrombosis
How is Waldenstrom's macroglobulinemia described?
,A. Abnormal IgA immunoglobulin produced from pathological plasma cells
B. Abnormal IgD immunoglobulin produced from pathological plasma cells
C. Abnormal IgG immunoglobulin produced from pathological plasma cells
D. abnormal IgM Immunoglobulin produced from pathological plasma cells - Answers abnormal
IgM Immunoglobulin produced from pathological plasma cells
The presence of this cell is definitive for Hodgkins Lymphoma:
A. Flame cell
B. Reed-Sternberg cell
C. dendritic cell
D. Plasma cell - Answers Reed-Sternberg cell
Which of the following is a B cell marker?
A. CD4
B. CD20
C. CD8
D. CD2 - Answers CD20
What is the most common chromosomal abnormality in Polycythemia Vera (PV)?
A. BCR-ABL
B. PML-RARA
C. TET2
D. JAK2V617F - Answers JAK2V617F
This finding can be present in both Multiple Myeloma and Waldenstrom's macroglobulinemia
A. High MCV
, B. Bence- Jones proteinuria
C. decreased serum iron
D. Glycosuria - Answers Bence- Jones proteinuria
Which of the following is an expected finding in polycythemia vera?
A. normal white cell count
B. anemia
C. increased RBC mass
D. low leukocyte alkaline phosphatase - Answers increased RBC mass
Which of the following is seen in Burkitt's Lymphoma?
A. granules stain reddish-orange
B. lymphocyte cells have hairy cytoplasmic projections
C. lymphocytic cells have vacuoles in basophilic cytoplasm
D. lymphocytic cells have Auer rods - Answers lymphocytic cells have vacuoles in basophilic
cytoplasm
A patient has a normal white cell count, a moderately high platelet count, and mild anemia. The
differential shows immature granulocytes, nucleated red cells, and teardrop-shaped red cells.
Which of the following is most likely?
A. chronic myelogenous leukemia
B. primary myelofibrosis
C. polycythemia vera
D. essential thrombocythemia - Answers primary myelofibrosis
Burkitt's Lymphoma has been linked to what virus?
A. Epstein-Barr
Why is Rouleaux formation associated with Multiple Myeloma and Waldenstrom's
macroglobulinemia?
A. abnormal proteins secreted from megakaryocytes coat red blood cells causing them to
appear stacked on the peripheral blood smear
B. abnormal proteins produced from T lymphocytes coat red blood cells causing them to
appear stacked on the peripheral blood smear
C. abnormal proteins produced from segmented neutrophils coat red blood cells causing them
to appear stacked on the peripheral blood smear
D. abnormal proteins produced from myeloma cells coat red blood cells causing them to
appear stacked on the peripheral blood smear - Answers abnormal proteins produced from
myeloma cells coat red blood cells causing them to appear stacked on the peripheral blood
smear
A "dry tap" bone marrow aspiration may be seen with what chronic myeloid proliferative disease?
A. Essential Thrombocythemia
B. Polycythemia Vera
C. Primary Myelofibrosis
D. Chronic Myeloid Leukemia - Answers Primary Myelofibrosis
What clinical feature is more often associated with essential thrombocythemia than with the
other chronic myeloproliferative disorders?
A. bleeding and thrombosis
B. infections
C. splenomegaly
D. fatigue - Answers bleeding and thrombosis
How is Waldenstrom's macroglobulinemia described?
,A. Abnormal IgA immunoglobulin produced from pathological plasma cells
B. Abnormal IgD immunoglobulin produced from pathological plasma cells
C. Abnormal IgG immunoglobulin produced from pathological plasma cells
D. abnormal IgM Immunoglobulin produced from pathological plasma cells - Answers abnormal
IgM Immunoglobulin produced from pathological plasma cells
The presence of this cell is definitive for Hodgkins Lymphoma:
A. Flame cell
B. Reed-Sternberg cell
C. dendritic cell
D. Plasma cell - Answers Reed-Sternberg cell
Which of the following is a B cell marker?
A. CD4
B. CD20
C. CD8
D. CD2 - Answers CD20
What is the most common chromosomal abnormality in Polycythemia Vera (PV)?
A. BCR-ABL
B. PML-RARA
C. TET2
D. JAK2V617F - Answers JAK2V617F
This finding can be present in both Multiple Myeloma and Waldenstrom's macroglobulinemia
A. High MCV
, B. Bence- Jones proteinuria
C. decreased serum iron
D. Glycosuria - Answers Bence- Jones proteinuria
Which of the following is an expected finding in polycythemia vera?
A. normal white cell count
B. anemia
C. increased RBC mass
D. low leukocyte alkaline phosphatase - Answers increased RBC mass
Which of the following is seen in Burkitt's Lymphoma?
A. granules stain reddish-orange
B. lymphocyte cells have hairy cytoplasmic projections
C. lymphocytic cells have vacuoles in basophilic cytoplasm
D. lymphocytic cells have Auer rods - Answers lymphocytic cells have vacuoles in basophilic
cytoplasm
A patient has a normal white cell count, a moderately high platelet count, and mild anemia. The
differential shows immature granulocytes, nucleated red cells, and teardrop-shaped red cells.
Which of the following is most likely?
A. chronic myelogenous leukemia
B. primary myelofibrosis
C. polycythemia vera
D. essential thrombocythemia - Answers primary myelofibrosis
Burkitt's Lymphoma has been linked to what virus?
A. Epstein-Barr
