GGG's CV Pharm Questions with Detailed
Verified Answers
HMG-CoA reductase inhibitor drugs
A. Are all inactive before hydrolyzed in the intestine
B. Bind irreversibly to the reductase enzyme
C. Have a low first pass effect
D. Inhibit cholesterol degradation in the liver
E. Inhibit steroid biosynthesis in the liver Ans: E. Inhibit steroid biosynthesis in the
liver. Statins resemble HMG-CoA in molecular shape and when bound act as
competitive antagonist (bind reversible). These drugs are used to treat
hypercholesterolemia by decreasing cholesterol synthesis in the liver resulting in the
up-regulation of liver LDL receptors. Note: only lovastatin and simvastatin are inactive
until hydrolyzed in the gut.
Which of the following is correctly matched?
Anti-arrhythmic Drug Class Drug
A. Class Ib : mexiletine
B. Class Ic : Ibutilide
C. Class II : Verapamil
D. Class III : Digoxin
E. Class IV : Adenosine Ans: A. Class Ib: mexiletine
Class 1(sodium channel blockers),
,1A: Disopyramide, procainamide, quinidine (Queen Amy Proclaims Diso's pyramid).
Amy goes with amiodarone which affects many channels
1B: lidocaine and oral derivatives--mexiletine and tocainide
1C: Flecainide, propafenone, and moricizine
Class 2 beta blockers
Class 3 K+ blockers
Class 4 CCB
Patients taking pravastatin with muscle pain should be checked periodically for a
potential increase(s) in serum
A. Aminotransferase
B. Creatinine Kinase
C. Lactate dehydrogenase
D. Phosphate
E. Potassium Ans: B. Creatinine Kinase
Myalgia, myopathy, and rhabdomyolysis can occur with Statin use. The degree of
muscle tissue damage is measured by CK levels.
Which statement is true regarding sublingual nitroglycerin use?
A. Sublingual nitroglycerin can be also used to reduce elevated intracranial pressure
B. Sublingual nitroglycerin has a half-life of approximately 6-10 hours
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,C. Sublingual nitroglycerin has poor bioavailability due to first-pass hepatic metabolism
D. Sublingual nitroglycerin used continually can result in loss of effect
E. Sublingual nitroglycerin usually results in bradycardia Ans: D. Sublingual
nitroglycerin used continually can result in loss of effect
Nitroglycerin is contraindicated in patients with elevated ICP (us produces vasodilation
and increased pressure). SC NG is used for acute episodes of stable angina (duration
of action) 10-30 min. SC avoids first pass. NG induced vasodilation = reflex
tachycardia.
Which of the following drugs is used to treat subarachnoid hemorrhage?
A. Bepridil
B. Esmolol
C. Isosorbide dinitrate
D. Nimodipine
E. Nitroglycerin (sublingual) Ans: D. Nimodipine. This drug has been shown to reduce
the incidence of ischemic complications (cerebral vasospasm) following aneurysmal
subarachnoid hemorrhage. Nitrates are contraindicated.
Which of the following drugs increases lipoprotein lipase (LPL) activity?
A. Atorvastatin
B. Colesevelam
C. Ezetimibe
D. Fenofibrate
© Get it right 2025 Getaway - Stuvia US All rights reserved
, E. Ticlopidine Ans: D. Fenofibrate. Fibrates are ligands for the transcriptional factor
PPAR alpha. PPAR alpha, produces many transcriptional changes regarding metabolism
of fat including the up-regulation of LPL enzymes. LPL functions to convert TG's into
FFA that shuttles TG from VLDL to muscle.
Which drug is correctly matched to its mechanism of action?
DRUG MECHANISM OF ACTION
A. Digoxin Nicotinic receptor antagonist
B. Dobutamine Aldosterone antagonist
C. Hydralazine Angiotensin-converting enzyme inhibitor
D. Inamrinone Phosphodiesterase inhibitor
E. Spironolactone Beta one adrenergic receptor agonist Ans: D. Inamrinone:
Phosphodiesterase inhibitor
Inamrinone is now discontinued in the US but was used clinically for short term
management of heart failure to increase contractility. Inamrinone's principle
mechanism of action is to inhibit the phosphodiesterase enzyme responsible for the
breakdown of cAMP in ventricular cardiac myocytes.The increase in intracellular levels
results in a more pronounced PKA effect. In cardiac myocytes PKA phosphorylates
calcium channels resulting in more calcium influx and release from SR increasing
contraction.
Digoxin is a Na/K ATPase inhibitor, dobutamine is "da" beta agonist, hydralazine is a
vasodilator, and spironolactone is an aldosterone antagonist.
The principle use for b-type natriuretic peptide (nesiritide) is to treat
A. Heart failure
B. Mild hypertension
© Get it right 2025 Getaway - Stuvia US All rights reserved
Verified Answers
HMG-CoA reductase inhibitor drugs
A. Are all inactive before hydrolyzed in the intestine
B. Bind irreversibly to the reductase enzyme
C. Have a low first pass effect
D. Inhibit cholesterol degradation in the liver
E. Inhibit steroid biosynthesis in the liver Ans: E. Inhibit steroid biosynthesis in the
liver. Statins resemble HMG-CoA in molecular shape and when bound act as
competitive antagonist (bind reversible). These drugs are used to treat
hypercholesterolemia by decreasing cholesterol synthesis in the liver resulting in the
up-regulation of liver LDL receptors. Note: only lovastatin and simvastatin are inactive
until hydrolyzed in the gut.
Which of the following is correctly matched?
Anti-arrhythmic Drug Class Drug
A. Class Ib : mexiletine
B. Class Ic : Ibutilide
C. Class II : Verapamil
D. Class III : Digoxin
E. Class IV : Adenosine Ans: A. Class Ib: mexiletine
Class 1(sodium channel blockers),
,1A: Disopyramide, procainamide, quinidine (Queen Amy Proclaims Diso's pyramid).
Amy goes with amiodarone which affects many channels
1B: lidocaine and oral derivatives--mexiletine and tocainide
1C: Flecainide, propafenone, and moricizine
Class 2 beta blockers
Class 3 K+ blockers
Class 4 CCB
Patients taking pravastatin with muscle pain should be checked periodically for a
potential increase(s) in serum
A. Aminotransferase
B. Creatinine Kinase
C. Lactate dehydrogenase
D. Phosphate
E. Potassium Ans: B. Creatinine Kinase
Myalgia, myopathy, and rhabdomyolysis can occur with Statin use. The degree of
muscle tissue damage is measured by CK levels.
Which statement is true regarding sublingual nitroglycerin use?
A. Sublingual nitroglycerin can be also used to reduce elevated intracranial pressure
B. Sublingual nitroglycerin has a half-life of approximately 6-10 hours
© Get it right 2025 Getaway - Stuvia US All rights reserved
,C. Sublingual nitroglycerin has poor bioavailability due to first-pass hepatic metabolism
D. Sublingual nitroglycerin used continually can result in loss of effect
E. Sublingual nitroglycerin usually results in bradycardia Ans: D. Sublingual
nitroglycerin used continually can result in loss of effect
Nitroglycerin is contraindicated in patients with elevated ICP (us produces vasodilation
and increased pressure). SC NG is used for acute episodes of stable angina (duration
of action) 10-30 min. SC avoids first pass. NG induced vasodilation = reflex
tachycardia.
Which of the following drugs is used to treat subarachnoid hemorrhage?
A. Bepridil
B. Esmolol
C. Isosorbide dinitrate
D. Nimodipine
E. Nitroglycerin (sublingual) Ans: D. Nimodipine. This drug has been shown to reduce
the incidence of ischemic complications (cerebral vasospasm) following aneurysmal
subarachnoid hemorrhage. Nitrates are contraindicated.
Which of the following drugs increases lipoprotein lipase (LPL) activity?
A. Atorvastatin
B. Colesevelam
C. Ezetimibe
D. Fenofibrate
© Get it right 2025 Getaway - Stuvia US All rights reserved
, E. Ticlopidine Ans: D. Fenofibrate. Fibrates are ligands for the transcriptional factor
PPAR alpha. PPAR alpha, produces many transcriptional changes regarding metabolism
of fat including the up-regulation of LPL enzymes. LPL functions to convert TG's into
FFA that shuttles TG from VLDL to muscle.
Which drug is correctly matched to its mechanism of action?
DRUG MECHANISM OF ACTION
A. Digoxin Nicotinic receptor antagonist
B. Dobutamine Aldosterone antagonist
C. Hydralazine Angiotensin-converting enzyme inhibitor
D. Inamrinone Phosphodiesterase inhibitor
E. Spironolactone Beta one adrenergic receptor agonist Ans: D. Inamrinone:
Phosphodiesterase inhibitor
Inamrinone is now discontinued in the US but was used clinically for short term
management of heart failure to increase contractility. Inamrinone's principle
mechanism of action is to inhibit the phosphodiesterase enzyme responsible for the
breakdown of cAMP in ventricular cardiac myocytes.The increase in intracellular levels
results in a more pronounced PKA effect. In cardiac myocytes PKA phosphorylates
calcium channels resulting in more calcium influx and release from SR increasing
contraction.
Digoxin is a Na/K ATPase inhibitor, dobutamine is "da" beta agonist, hydralazine is a
vasodilator, and spironolactone is an aldosterone antagonist.
The principle use for b-type natriuretic peptide (nesiritide) is to treat
A. Heart failure
B. Mild hypertension
© Get it right 2025 Getaway - Stuvia US All rights reserved
