APhA NAPLEX EXAM Questions AND Correct Answers
A solution containing 55% ethyl alcohol is required. Solution of 15%
and 80% ethyl alcohol are available. What volume of the 15% solution
is required to make 100mL?
A. 64.8mL
B. 41.7mL
C. 61.5mL
D. 38.5mL - ✔✔D. Using alligation: 25parts/65parts=x/100mL
80____________ = 55-15 = 40 parts of 80%
55
15_____________ = 80-55 = 25 parts of 15%
TOTAL = 65 parts
(note: larger number on top!)
According to the Noyes-Whitney equation, the drug concentration
immediately at the solid surface within the diffusion layer (stagnant
layer) is recognized as the
A. drug solubility
B. dissolution rate
C. thickness layer
,D. diffusion coefficient - ✔✔A. According to the Noyes-Whitney
equation, the drug concentration in the stagnant layer is equal to the
drug solubility
Adding PEG groups to large molecules will enhance their
A. absorption through the intestine
B. solubility
C. oxidation
D. degradation - ✔✔B. PEG groups increase the solubility of the
molecule
Agents that may be used in the enteric coating of tablets include
A. hydroxypropyl methycellulose
B. carboxymethylcellulose
C. cellulose acetate phtalate
D. none of the above - ✔✔C. An enteric-coated tablet has a coating
that remains intact in the stomach but dissolves in the intestine when
the pH exceeds 6. Enteric-coating materials include cellulose acetate
phthalate, polyvinyl acetate phthalate, and hydroxypropyl
methylcellulose phthalate
An example of a diagnostic skeletal agent is
,A. Tc-99m bicisate
B. Tc-99m MDP
C. Sr-82 chloride
D. Florbetapir F-18 - ✔✔B. Tc-99m bicisate and florbetapir F-18 are for
CNS imaging. Sr 82 chloride is a palliative therapeutic agent
An example of a radiolabeled peptide that is used in localized primary
and metastatic neuroendocrine tumors is
A. In-111 pentetreotide
B. I-123 iobenguane
C. In-111 capromab pendetide
D. I-123 ioflupane - ✔✔A. I-123 benguane is used in the detection of
pheochromocytomas and neuroblastomas, but is not a peptide, In-111
capromab is a monoclonal antibody used in pts with prostate cancer.
I-123 ioflupane is used in the eval of pts with parkinsonian syndromes
As an o/w type of ointment base, hydrophilic ointment, USP, possess
which property?
A. emollient
B. greasy
C. occlusive
, D. water washable - ✔✔D. Hydrophilic ointment is water washable
and does not posses the other properties listed of being an emollient
that softens the skin, of being greasy because the external phase is
water, and of being occlusive because it prevents water from
evaporating from the skin
Calcium and phosphate can interact to form a precipitate in
parenteral nutrition solutions. Of the follow situations, which would
not enhance calcium and phosphate precipitate formation?
A. high concentration of calcium and phosphate
B. increase in solution pH
C. decrease in temperature
D. use of the chloride salt of calcium
E. a slow infusion rate - ✔✔C. an increase in temperature could
enhance precipitate formation
Certain factors may increase the risk of microbial contamination of a
CSP. Which of the following would not be a risk factor?
A. very complex compounding steps
B. lengthy exposure of a critical site during compounding
C. use of appropriate aseptic technique
D. batch compounding without preservatives for multiple patients
A solution containing 55% ethyl alcohol is required. Solution of 15%
and 80% ethyl alcohol are available. What volume of the 15% solution
is required to make 100mL?
A. 64.8mL
B. 41.7mL
C. 61.5mL
D. 38.5mL - ✔✔D. Using alligation: 25parts/65parts=x/100mL
80____________ = 55-15 = 40 parts of 80%
55
15_____________ = 80-55 = 25 parts of 15%
TOTAL = 65 parts
(note: larger number on top!)
According to the Noyes-Whitney equation, the drug concentration
immediately at the solid surface within the diffusion layer (stagnant
layer) is recognized as the
A. drug solubility
B. dissolution rate
C. thickness layer
,D. diffusion coefficient - ✔✔A. According to the Noyes-Whitney
equation, the drug concentration in the stagnant layer is equal to the
drug solubility
Adding PEG groups to large molecules will enhance their
A. absorption through the intestine
B. solubility
C. oxidation
D. degradation - ✔✔B. PEG groups increase the solubility of the
molecule
Agents that may be used in the enteric coating of tablets include
A. hydroxypropyl methycellulose
B. carboxymethylcellulose
C. cellulose acetate phtalate
D. none of the above - ✔✔C. An enteric-coated tablet has a coating
that remains intact in the stomach but dissolves in the intestine when
the pH exceeds 6. Enteric-coating materials include cellulose acetate
phthalate, polyvinyl acetate phthalate, and hydroxypropyl
methylcellulose phthalate
An example of a diagnostic skeletal agent is
,A. Tc-99m bicisate
B. Tc-99m MDP
C. Sr-82 chloride
D. Florbetapir F-18 - ✔✔B. Tc-99m bicisate and florbetapir F-18 are for
CNS imaging. Sr 82 chloride is a palliative therapeutic agent
An example of a radiolabeled peptide that is used in localized primary
and metastatic neuroendocrine tumors is
A. In-111 pentetreotide
B. I-123 iobenguane
C. In-111 capromab pendetide
D. I-123 ioflupane - ✔✔A. I-123 benguane is used in the detection of
pheochromocytomas and neuroblastomas, but is not a peptide, In-111
capromab is a monoclonal antibody used in pts with prostate cancer.
I-123 ioflupane is used in the eval of pts with parkinsonian syndromes
As an o/w type of ointment base, hydrophilic ointment, USP, possess
which property?
A. emollient
B. greasy
C. occlusive
, D. water washable - ✔✔D. Hydrophilic ointment is water washable
and does not posses the other properties listed of being an emollient
that softens the skin, of being greasy because the external phase is
water, and of being occlusive because it prevents water from
evaporating from the skin
Calcium and phosphate can interact to form a precipitate in
parenteral nutrition solutions. Of the follow situations, which would
not enhance calcium and phosphate precipitate formation?
A. high concentration of calcium and phosphate
B. increase in solution pH
C. decrease in temperature
D. use of the chloride salt of calcium
E. a slow infusion rate - ✔✔C. an increase in temperature could
enhance precipitate formation
Certain factors may increase the risk of microbial contamination of a
CSP. Which of the following would not be a risk factor?
A. very complex compounding steps
B. lengthy exposure of a critical site during compounding
C. use of appropriate aseptic technique
D. batch compounding without preservatives for multiple patients
