Verified Solutions) 2025/2026 Update b b b b
What are the 5 WHO prescribing guidelines? - CORRECT ANSWER -1. define the pt's problem
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2. Specify therapeutic objectives b b
3. choose which drug or treatment is needed
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4. Write the Rx and start txb b b b b
5. Educate and counsel the pt b b b b
6. monitor effect of treatment b b b
WHO rx guideline 1 - CORRECT ANSWER -Define the pt's problem . This forms the basis for
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choosing and rx-ing the correct treatment.
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Consultation should include: complaints, symptoms, diagnosis and relevant characteristics like co-
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morbidities, co-medication, pregnancy, drug allergies
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WHO rx guideline 2 - CORRECT ANSWER -Specify the therapeutic objective. What needs to be
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treated?
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WHO rx guideline 3 - CORRECT ANSWER -3a. select the p-drug (prescribers personal drug of first choice
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for the indication.)
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3b.Is the p-drug appropriate? checking for contraindications, interactions, pregnancy, allergies, etc.
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WHO rx guideline 4 - CORRECT ANSWER -Write rx and start the treatment.
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WHO rx guideline 5 - CORRECT ANSWER -Educate and counsel the pt. Intructions and warnings about
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the tx.
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,WHO rx 6 - CORRECT ANSWER -Monitor the treatment.
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Coreg (Carvedilol) - CORRECT ANSWER -*beta blocker used to treat mild to severe CHF, left ventricular
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dysfunction following MI, HTN.
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*works by causing vasodilation to the peripheral vasculature to decrease the workload on the
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heart.
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*Non selective beta blocker and Alpha-1 blocker
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*3rd generation beta blocker
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*particularly useful in African Americans b b b b
*Dose: 0.625 mg-25mg PO BID with food b b b b b b
*administering with food helps prevent postural hypotension b b b b b b
*Education: don't skip doses, take with food b b b b b b
hypersensitivty reactions: mnemonic ACID - CORRECT ANSWER -1. A-allergic b b b b b b b b
2.C-cytotoxic
3.I- Immune complex deposition
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4. D-delayed
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Type I hypersensitivity - CORRECT ANSWER -A-allergic
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*IgE mediated- quick onset after exposure
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*production of IgE after antigen exposure. b b b b b
*urticaria, wheezing, rhinitis, anaphylaxis b b b
Type II hypersensitivity - CORRECT ANSWER -C-cytotoxic
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*cytotoxic/antibody mediated b
* drug binds to RBCs and is recognized by antibody-usually IgG
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*complement and cytotoxic T cells are activated b b b b b b
, *Rare response b
Type III hypersensitivity - CORRECT ANSWER -I-immune complex/IgG/IgM mediated
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*antibodies are formed against soluble antigens.ANtigen-antibody complexes are deposited in tissues
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such as joints and lungs.
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*cause serum sickness. Ex: ceclor (antibiotic)
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Type IV hypersensitivity - CORRECT ANSWER -D-delayed- delayed or cell mediated
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*cytotoxic T cells are activated b b b b
*poison ivy,latex, etc b b b
*causes contact dermatitis b b
*cytokine storm if there is repeated exposure b b b b b b
Grapefruit juice - CORRECT ANSWER -*increases drug toxicity
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*don't drink with SSRIs, calcium channel blockers, statins, benzos
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*increases absorption and decreases the metabolism b b b b b
Atropine-class/mechanism of action - CORRECT ANSWER -*anticholinergic b b b b b b
*inhibits action of acetylcholine and blocks the PNS.
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*Increases HR by increasing conduction int eh SA and AV node
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atropine- indications - CORRECT ANSWER -*symptomatic bradycardia (sinus, junctional, AV
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blocks, causing significant hypotension, ventricular ectopy, angina, etc.)
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*organphosphate poisoning b
* RSI in peds
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*beta blocker and calcium channel blocker overdose
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