9/26/25, 3:51 PM NBME - NEW TESTS <span style="color:#000;font-weight:bold;">1300+</span> (2025-2026 A+ Graded) Exam-Style Questions | V…
NBME - NEW TEST QUESTIONS AND
ANSWERS LATEST
Question 1
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected
beneficial effect of the drug is due to which of the following?
Correct Answer
Decreased Osteoclast Activity
Question 2
Cohot Study of elderly women – relative risk ratio for hip fractures among those
who exercise regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the
following is the conclusion about the effect of exercise on the risk of hip fracture?
Correct Answer
Statistically Significant Overall Increase Risk
Question 3
52 year old man goes to ER with chest pain radiating to his jaw while shoveling
snow. Pulse is 80/min and blood pressure is 130/70. The most immediate treatment
mechanism of action?
Correct Answer
Increased nitric oxide concentration
Page 1 of 416
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,9/26/25, 3:51 PM NBME - NEW TESTS <span style="color:#000;font-weight:bold;">1300+</span> (2025-2026 A+ Graded) Exam-Style Questions | V…
Question 4
24 year old woman – spilled hot grease on her left leg while working at a fast-food
restaurant. Exam of leg shows 7cm pink, soft, granular, edematous wound. The
formation of this tissue was most likely caused by increased activity of which?
Correct Answer
a. Vascular Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels – early wound repair
Question 5
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull
fracture – increased serum osm and decreased urin osm. Following desmopressin
urine osm increases. Desmopressin’s effect is due to the activation of which of the
following?
Correct Answer
a. Adenylyl Cyclase
Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
Question 6
A 10 month old boy – 4 day history of fever and cough. He attends day care center.
Chest exam shows intercostal retractions along with bilateral, diffuse wheezes and
expiratory rhonchi. The infectious agent most likely has which of the following
properties?
Correct Answer
Mediation of Cell Entry via a fusion protein
Page 2 of 416
2/416
,9/26/25, 3:51 PM NBME - NEW TESTS <span style="color:#000;font-weight:bold;">1300+</span> (2025-2026 A+ Graded) Exam-Style Questions | V…
Question 7
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light
headedness but no difficulty swallowing- Bilateral wheezing - Which is most
appropriate pharmacotherapy for this patient?
Correct Answer
B2- Agonist
Question 8
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1
week of fatigue. He recentaly had sex with one partner. Physical exam show cervical
lymphadenopathy and pharyngeal erythema with a creamy exudate. DX?
Correct Answer
Infectious Mononucleosis
Question 9
57 year old man – radiation therapy for squamous cell carcinoma of the lung.
Despite therapy, tumor increases in size and he dies 6 months later. The progressive
tumor growth is due to a defect in cell cycle arrest in which of the following phases
of cell cycle?
Correct Answer
G1
Question 10
28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 –
imaging shows bilateral hydroureter and hydronephrosis. Biopsy shows marked
fibrosis and scattered granulomas. DX?
Correct Answer
Schistosomiasis
Page 3 of 416
3/416
, 9/26/25, 3:51 PM NBME - NEW TESTS <span style="color:#000;font-weight:bold;">1300+</span> (2025-2026 A+ Graded) Exam-Style Questions | V…
Question 11
A couple with a family history of a-thalassemia. Woman has one gene deletion and
man has two gene deletion. If the two gene is trans – what percentage of offspring
will have a two gene deletion?
Correct Answer
50%
Question 12
previously healthy 40 year brought to emergency department by her husband – 2 day
history of fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses
over the lower extremities – 3+ polychromasia and 3+ schistocytes and Low
platelets Dx?
Correct Answer
Thrombotic Thrombocytopenia Purpura
Question 13
16 year old boy – is admitted to the ER because of a knife wound to the left side of
his chest. An X-ray of the chest shows an air-fluid level in the left side of the chest,
partial collapse of the left lung, and the elevation of the stomach bubble. The
mediastinum is midline. DX?
Correct Answer
Hemopneumpothorax under tension
Page 4 of 416
4/416
NBME - NEW TEST QUESTIONS AND
ANSWERS LATEST
Question 1
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected
beneficial effect of the drug is due to which of the following?
Correct Answer
Decreased Osteoclast Activity
Question 2
Cohot Study of elderly women – relative risk ratio for hip fractures among those
who exercise regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the
following is the conclusion about the effect of exercise on the risk of hip fracture?
Correct Answer
Statistically Significant Overall Increase Risk
Question 3
52 year old man goes to ER with chest pain radiating to his jaw while shoveling
snow. Pulse is 80/min and blood pressure is 130/70. The most immediate treatment
mechanism of action?
Correct Answer
Increased nitric oxide concentration
Page 1 of 416
1/416
,9/26/25, 3:51 PM NBME - NEW TESTS <span style="color:#000;font-weight:bold;">1300+</span> (2025-2026 A+ Graded) Exam-Style Questions | V…
Question 4
24 year old woman – spilled hot grease on her left leg while working at a fast-food
restaurant. Exam of leg shows 7cm pink, soft, granular, edematous wound. The
formation of this tissue was most likely caused by increased activity of which?
Correct Answer
a. Vascular Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels – early wound repair
Question 5
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull
fracture – increased serum osm and decreased urin osm. Following desmopressin
urine osm increases. Desmopressin’s effect is due to the activation of which of the
following?
Correct Answer
a. Adenylyl Cyclase
Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
Question 6
A 10 month old boy – 4 day history of fever and cough. He attends day care center.
Chest exam shows intercostal retractions along with bilateral, diffuse wheezes and
expiratory rhonchi. The infectious agent most likely has which of the following
properties?
Correct Answer
Mediation of Cell Entry via a fusion protein
Page 2 of 416
2/416
,9/26/25, 3:51 PM NBME - NEW TESTS <span style="color:#000;font-weight:bold;">1300+</span> (2025-2026 A+ Graded) Exam-Style Questions | V…
Question 7
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light
headedness but no difficulty swallowing- Bilateral wheezing - Which is most
appropriate pharmacotherapy for this patient?
Correct Answer
B2- Agonist
Question 8
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1
week of fatigue. He recentaly had sex with one partner. Physical exam show cervical
lymphadenopathy and pharyngeal erythema with a creamy exudate. DX?
Correct Answer
Infectious Mononucleosis
Question 9
57 year old man – radiation therapy for squamous cell carcinoma of the lung.
Despite therapy, tumor increases in size and he dies 6 months later. The progressive
tumor growth is due to a defect in cell cycle arrest in which of the following phases
of cell cycle?
Correct Answer
G1
Question 10
28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 –
imaging shows bilateral hydroureter and hydronephrosis. Biopsy shows marked
fibrosis and scattered granulomas. DX?
Correct Answer
Schistosomiasis
Page 3 of 416
3/416
, 9/26/25, 3:51 PM NBME - NEW TESTS <span style="color:#000;font-weight:bold;">1300+</span> (2025-2026 A+ Graded) Exam-Style Questions | V…
Question 11
A couple with a family history of a-thalassemia. Woman has one gene deletion and
man has two gene deletion. If the two gene is trans – what percentage of offspring
will have a two gene deletion?
Correct Answer
50%
Question 12
previously healthy 40 year brought to emergency department by her husband – 2 day
history of fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses
over the lower extremities – 3+ polychromasia and 3+ schistocytes and Low
platelets Dx?
Correct Answer
Thrombotic Thrombocytopenia Purpura
Question 13
16 year old boy – is admitted to the ER because of a knife wound to the left side of
his chest. An X-ray of the chest shows an air-fluid level in the left side of the chest,
partial collapse of the left lung, and the elevation of the stomach bubble. The
mediastinum is midline. DX?
Correct Answer
Hemopneumpothorax under tension
Page 4 of 416
4/416
