Samenvatting Schema structuren medicinale chemie

DEEL 1
H1: ACETYLCHOLINE & CHOLINERGE RECEPTOREN




acetylcholine muscarine nicotine


M1-receptor: agonist antagonist




xanomeline


Pirenzepine



M2-receptor: antagonisten




methoctramine

AF-DX 116


M3-receptor: antagonisten




1
darifenacine
hexahydro-sila-difenidol

,Nicotine-agonisten


Relatieve activiteit
(equipotente concentratie)

R1 R2 Config. Muscarine Nicotine receptor O b a
receptor H H
H3C C O C C N(CH3)3
H H 1 1
R2 R1
CH3 (α) H R/S 49 2

H CH3 (β) R/S 1,6 180



Varenicline: partiële agonist




Ganglionblokkers




2

,Neuromusculaire blokkers

O
O N
N O
O
succinylcholine
cisatracurium

tubocurarine pancuronium R = CH3

N vecuronium R = H
N
decamethonium


mivacurium



rocuronium gallamine




Selective relaxant binding agent




suggamadex
3

, Lokale anesthetica




cocaïne benzoyltropine
oxybuprocaïne tetracaïne proxymetacaïne




b-eucaïne orthocaïne R = NH2; R' = OH
orthocaïne new R = OH; R' = NH2
benzocaïne amylocaïne procaïne




4