,Test Bank
bb b b Rubin's b b Pathology: Clinicopathologic Foundations b b b b b b of b b Medicine b b 7th b b
Edition
b b
Table of Contents:
b b b b
Chapter 1: Cell Adaptation, Injury and Death
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Chapter 2: Inflammation
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Chapter 3: Repair, Regeneration and Fibrosis
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Chapter 4: Immunopathology
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Chapter 5: Neoplasia
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Chapter 6: Developmental and Genetic Diseases
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Chapter 7: Hemodynamic Disorders
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Chapter 8: Environmental and Nutritional Pathology
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Chapter 9: Infectious and Parasitic Diseases
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Section II: Pathogenesis of Systemic Conditions Expandable section
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Chapter 10: Agingb b b b
Chapter 11: Systemic Autoimmune Diseases
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Chapter 12: Sepsis
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Chapter 13: Obesity and Diabetes Mellitus
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Chapter 14: The Pathology of Pregnancy
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Chapter 15: The Amyloidoses
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Section III: Diseases of Individual Organ SystemsExpandable section
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Chapter 16: Blood Vessels
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Chapter 17: The Heart
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Chapter 18: The Respiratory System
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Chapter 19: The Gastrointestinal Tract
bb b b b b b b
Chapter 20: The Liver and Biliary System
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Chapter 21: The Pancreas
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Chapter 22: The Kidney
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Chapter 23: The Lower Urinary Tract and Male Reproductive System
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Chapter 24: The Female Reproductive System and Peritoneum
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Chapter 25: The Breast
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Chapter 26: Hematopathology
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Chapter 27: The Endocrine System
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Chapter 28: The Skin
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Chapter 29: The Head and Neck
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Chapter 30: Bones, Joints and Soft Tissue
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Chapter 31: Skeletal Muscle and Peripheral Nervous System
bb b b b b b b b b b b b b
Chapter 32: The Central Nervous System
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Chapter 33: The Eye
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Chapter 34: Forensic Pathology
bb b b b b
,Rubin's Pathology: Clinicopathologic Foundations of Medicine
bb bb bb bb bb
Chapter 1: Cell Adaptation, Injury and Death
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Ischemia and other toxic injuries increase the accumulation of intracellular
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1. bbcalcium as a result of: bb bb bb b b
A) release of stored calcium from the mitochondria.
b b bb bb b b bb b b
B) improved intracellular volume regulation. bb bb bb
C) decreased influx across the cell membrane. b b b b bb bb bb
D) attraction of calcium to fatty infiltrates.
b b b b b b bb bb
The patient is found to have liver disease, resulting in the removal of a
b b b b b b b b b b b b b b b b b b b b b b b b b b
2. lobe of his liver. Adaptation to the reduced size of the liver leads to
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_ of the remaining liver cells.
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A) metaplasia
B) organ atrophy bb
C) compensatory hyperplasia bb
D) physiologic hypertrophy bb
A person eating peanuts starts choking and collapses. His airway
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obstruction is partially cleared, but he remains hypoxic until he
b b b b bb b b b b b b b b b b b b b b
3. reaches the hospital. The prolonged cell hypoxia caused a cerebral
b b b b b b b b bb b b b b b b b b b b
infarction and resulting
b b b b _ in the b b bb bb
brain.
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A) caspase activation bb
B) coagulation necrosis bb
C) rapid phagocytosis bb
D) protein p53 deficiency bb b b
Bacteria and viruses cause cell damage by
b b , which is unique
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4. from the intracellular damage caused by other injurious agents.
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A) disrupting the sodium/potassium ATPase pumpbb b b b b bb
B) interrupting oxidative metabolism processes b b bb bb
C) replicating and producing continued bb bb bb b b injury
D) decreasing protein synthesis and function bb bb b b bb
The patient has a prolonged interruption in arterial blood flow to his left kidney,
bb b b bb bb b b b b bb bb b b bb bb b b bb
5. bbcausing hypoxic cell injury and the release of free radicals. Free radicals
bb b b b b b b b b b b b b b b b b b b b b
damage cells by:
b b b b b b
A) destroying phospholipids in the cell membrane. bb b b bb bb bb
, B) altering the immune response of the cell.
bb b b bb b b bb bb
C) disrupting calcium storage in the cell.
bb bb b b bb bb
D) inactivation of enzymes and mitochondria. b b bb b b bb
6. Injured cells have impaired flow of substances through the cell membrane as a
bb b b b b b b b b bb b b bb bb bb b b bb
result of:
bb b b
A) increased fat load. bb bb
B) altered permeability.
bb
C) altered glucose utilization.
bb bb
D) increased surface receptors.
bb bb
7. Reversible adaptive intracellular responses are initiated by:
bb b b bb b b bb b b
A) stimulus overload. b b
B) genetic mutations.
bb
C) chemical messengers. bb
D) mitochondrial DNA. bb
8. Injured cells become very swollen as a result
bb b b b b bb b b b b bb b b of:
A) increased cell protein synthesis.
b b bb bb
B) altered cell volume regulation.
bb b b bb
C) passive entry of potassium
b b bb bb b b into the cell. bb bb
D) bleb formation in the plasma membrane.
b b b b b b bb bb
A diabetic patient has impaired sensation, circulation, and oxygenation of his
bb bb bb bb bb bb bb bb bb bb
feet. He steps on a piece of glass, the wound does not heal, and the
bb bb bb b b b b b b b b b b b b b b b b b b b b b b b b
9. area tissue becomes necrotic. The necrotic cell death is characterized by:
b b b b b b bb b b b b b b b b b b b b b b
A) rapid apoptosis.
bb
B) cellular rupture. bb
C) shrinkage and collapse. bb bb
D) chronic inflammation.
bb
A 99-year-old woman has experienced the decline of cell function associated with
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10. age. A group of theories of cellular aging focus on programmed:
bb bb bb b b b b b b b b b b b b b b b b
A) changes with genetic influences.
b b bb bb
B) elimination of cell receptor sites. b b bb bb bb
C) insufficient telomerase enzyme. bb bb
D) DNA mutation or faulty repair.
bb b b b b bb
bb b b Rubin's b b Pathology: Clinicopathologic Foundations b b b b b b of b b Medicine b b 7th b b
Edition
b b
Table of Contents:
b b b b
Chapter 1: Cell Adaptation, Injury and Death
bb b b b b b b bb b b
Chapter 2: Inflammation
b b b b
Chapter 3: Repair, Regeneration and Fibrosis
bb b b b b b b b b
Chapter 4: Immunopathology
b b b b
Chapter 5: Neoplasia
b b b b
Chapter 6: Developmental and Genetic Diseases
bb b b b b b b b b
Chapter 7: Hemodynamic Disorders
b b b b b b
Chapter 8: Environmental and Nutritional Pathology
bb b b b b b b b b
Chapter 9: Infectious and Parasitic Diseases
bb b b b b b b b b
Section II: Pathogenesis of Systemic Conditions Expandable section
b b b b b b b b b b b b b b
Chapter 10: Agingb b b b
Chapter 11: Systemic Autoimmune Diseases
bb b b b b b b
Chapter 12: Sepsis
b b b b
Chapter 13: Obesity and Diabetes Mellitus
b b b b bb b b b b
Chapter 14: The Pathology of Pregnancy
b b b b b b bb b b
Chapter 15: The Amyloidoses
b b b b b b
Section III: Diseases of Individual Organ SystemsExpandable section
bb b b b b b b b b b b b b
Chapter 16: Blood Vessels
b b b b b b
Chapter 17: The Heart
bb b b b b
Chapter 18: The Respiratory System
bb b b b b bb
Chapter 19: The Gastrointestinal Tract
bb b b b b b b
Chapter 20: The Liver and Biliary System
b b b b b b b b b b bb
Chapter 21: The Pancreas
b b b b b b
Chapter 22: The Kidney
b b b b b b
Chapter 23: The Lower Urinary Tract and Male Reproductive System
bb b b b b b b bb b b b b b b b b
Chapter 24: The Female Reproductive System and Peritoneum
bb b b b b b b b b b b b b
Chapter 25: The Breast
b b b b b b
Chapter 26: Hematopathology
b b b b
Chapter 27: The Endocrine System
b b b b b b b b
Chapter 28: The Skin
bb b b b b
Chapter 29: The Head and Neck
b b b b b b b b b b
Chapter 30: Bones, Joints and Soft Tissue
bb b b b b b b b b b b
Chapter 31: Skeletal Muscle and Peripheral Nervous System
bb b b b b b b b b b b b b
Chapter 32: The Central Nervous System
bb b b bb b b b b
Chapter 33: The Eye
b b b b b b
Chapter 34: Forensic Pathology
bb b b b b
,Rubin's Pathology: Clinicopathologic Foundations of Medicine
bb bb bb bb bb
Chapter 1: Cell Adaptation, Injury and Death
bb b b b b b b b b b b b b
Ischemia and other toxic injuries increase the accumulation of intracellular
bb bb bb bb b b bb bb bb bb
1. bbcalcium as a result of: bb bb bb b b
A) release of stored calcium from the mitochondria.
b b bb bb b b bb b b
B) improved intracellular volume regulation. bb bb bb
C) decreased influx across the cell membrane. b b b b bb bb bb
D) attraction of calcium to fatty infiltrates.
b b b b b b bb bb
The patient is found to have liver disease, resulting in the removal of a
b b b b b b b b b b b b b b b b b b b b b b b b b b
2. lobe of his liver. Adaptation to the reduced size of the liver leads to
b b b b b b bb b b b b b b b b b b b b b b b b b b b b
_ of the remaining liver cells.
b b b b bb bb bb bb
A) metaplasia
B) organ atrophy bb
C) compensatory hyperplasia bb
D) physiologic hypertrophy bb
A person eating peanuts starts choking and collapses. His airway
b b b b b b b b b b b b b b b b b b
obstruction is partially cleared, but he remains hypoxic until he
b b b b bb b b b b b b b b b b b b b b
3. reaches the hospital. The prolonged cell hypoxia caused a cerebral
b b b b b b b b bb b b b b b b b b b b
infarction and resulting
b b b b _ in the b b bb bb
brain.
bb
A) caspase activation bb
B) coagulation necrosis bb
C) rapid phagocytosis bb
D) protein p53 deficiency bb b b
Bacteria and viruses cause cell damage by
b b , which is unique
b b b b b b b b b b bb bb bb
4. from the intracellular damage caused by other injurious agents.
bb bb bb b b b b b b b b b b b b
A) disrupting the sodium/potassium ATPase pumpbb b b b b bb
B) interrupting oxidative metabolism processes b b bb bb
C) replicating and producing continued bb bb bb b b injury
D) decreasing protein synthesis and function bb bb b b bb
The patient has a prolonged interruption in arterial blood flow to his left kidney,
bb b b bb bb b b b b bb bb b b bb bb b b bb
5. bbcausing hypoxic cell injury and the release of free radicals. Free radicals
bb b b b b b b b b b b b b b b b b b b b b
damage cells by:
b b b b b b
A) destroying phospholipids in the cell membrane. bb b b bb bb bb
, B) altering the immune response of the cell.
bb b b bb b b bb bb
C) disrupting calcium storage in the cell.
bb bb b b bb bb
D) inactivation of enzymes and mitochondria. b b bb b b bb
6. Injured cells have impaired flow of substances through the cell membrane as a
bb b b b b b b b b bb b b bb bb bb b b bb
result of:
bb b b
A) increased fat load. bb bb
B) altered permeability.
bb
C) altered glucose utilization.
bb bb
D) increased surface receptors.
bb bb
7. Reversible adaptive intracellular responses are initiated by:
bb b b bb b b bb b b
A) stimulus overload. b b
B) genetic mutations.
bb
C) chemical messengers. bb
D) mitochondrial DNA. bb
8. Injured cells become very swollen as a result
bb b b b b bb b b b b bb b b of:
A) increased cell protein synthesis.
b b bb bb
B) altered cell volume regulation.
bb b b bb
C) passive entry of potassium
b b bb bb b b into the cell. bb bb
D) bleb formation in the plasma membrane.
b b b b b b bb bb
A diabetic patient has impaired sensation, circulation, and oxygenation of his
bb bb bb bb bb bb bb bb bb bb
feet. He steps on a piece of glass, the wound does not heal, and the
bb bb bb b b b b b b b b b b b b b b b b b b b b b b b b
9. area tissue becomes necrotic. The necrotic cell death is characterized by:
b b b b b b bb b b b b b b b b b b b b b b
A) rapid apoptosis.
bb
B) cellular rupture. bb
C) shrinkage and collapse. bb bb
D) chronic inflammation.
bb
A 99-year-old woman has experienced the decline of cell function associated with
bb bb bb bb bb bb bb bb bb bb bb
10. age. A group of theories of cellular aging focus on programmed:
bb bb bb b b b b b b b b b b b b b b b b
A) changes with genetic influences.
b b bb bb
B) elimination of cell receptor sites. b b bb bb bb
C) insufficient telomerase enzyme. bb bb
D) DNA mutation or faulty repair.
bb b b b b bb
