USA NU578 Exam 3 – Questions With Objective
Solutions
What is the moa for diuretics? Accurate Answer:- Affects Maintenance
of ecf volume and composition
What is the Path that urine takes through the nephron Accurate Answer:-
Glomerulus▶️Prox convol tube▶️Loop of Henle: Descrnding limb▶️Ascending
limb▶️DCT▶️Collecting duct
What is the site of action for osmotic diuretics like
Mannitol? Accurate Answer:- Proximal convoluted tubule
What is the Site of action for Thiazide diuretics like
HCTZ? Accurate Answer:- Early distal convoluted tubule
What is the (site of action for Potassium sparing diuretics like
Spironolactone? Accurate Answer:- Late distal convoluted tubule and
collecting duct (distal nephron)
What is the sote of action for Loop diuretics like
Furosemide? Accurate Answer:- Loop of Henle
Loop diuretics cause drug toxicity due to increased Na+ excretion.
Accurate Answer:- Lithium excretion is decreased with hyponatremia and
causes lithium toxicity.
Nephron order of diuretic action Accurate Answer:- Osmotics▶️Loops
▶️Thiazides▶️K+ sparing
PCT (proximal convoluted tubule) Accurate Answer:- High resorptive
capacity. About 65% of filtered Na+ and Cl resorbed here. Urine is isotonic
Freely permeable to water Accurate Answer:- Descending limb loop of
Henle
Na/K exchange: Na+ reabsorbed, K+ excreted stimulated by Accurate
Answer:- Distal nephron: late DCT/CD
, Causes transient deafness Accurate Answer:- Furosemide
Only diuretic class that is ototoxic Accurate Answer:- Loop diuretics
(pg451)
Digoxin is potentiated with hypokalemia and ventricular dysrhythmias are
greatly increased. These diuretics promote K+ loss. Accurate Answer:-
Loop diuretics
Thiazide diuretics
Preferred drugs for mobilizing edema associated with mild to moderate 💕
failure Accurate Answer:- Thiazides
Diuretic Must be given parenterally. Only osmotic avail in US Accurate
Answer:- Mannitol
Diuretic Works on distal nephron to block Na+ and K+ Exchange Accurate
Answer:- Midamor
Hypokalemia is a special problem for patients taking ________ Accurate
Answer:- Digoxin
p.456
Aldactone Accurate Answer:- Blocks aldosterone in distal nephron
therefore there is LESS potassium excreted and more sodium
First line drugs for hypertension Accurate Answer:- Thiazides
Reduction of blood volume and reduction of arterial resistance (MOA)
Accurate Answer:- Thiazide diuretics
Principle adverse effect is hypokalemia Accurate Answer:- Thiazides
Produce much greater diuresis than thiazides Accurate Answer:- Loop
diuretics
Diuretics not used routinely for HTN Accurate Answer:- Loop diuretics
Solutions
What is the moa for diuretics? Accurate Answer:- Affects Maintenance
of ecf volume and composition
What is the Path that urine takes through the nephron Accurate Answer:-
Glomerulus▶️Prox convol tube▶️Loop of Henle: Descrnding limb▶️Ascending
limb▶️DCT▶️Collecting duct
What is the site of action for osmotic diuretics like
Mannitol? Accurate Answer:- Proximal convoluted tubule
What is the Site of action for Thiazide diuretics like
HCTZ? Accurate Answer:- Early distal convoluted tubule
What is the (site of action for Potassium sparing diuretics like
Spironolactone? Accurate Answer:- Late distal convoluted tubule and
collecting duct (distal nephron)
What is the sote of action for Loop diuretics like
Furosemide? Accurate Answer:- Loop of Henle
Loop diuretics cause drug toxicity due to increased Na+ excretion.
Accurate Answer:- Lithium excretion is decreased with hyponatremia and
causes lithium toxicity.
Nephron order of diuretic action Accurate Answer:- Osmotics▶️Loops
▶️Thiazides▶️K+ sparing
PCT (proximal convoluted tubule) Accurate Answer:- High resorptive
capacity. About 65% of filtered Na+ and Cl resorbed here. Urine is isotonic
Freely permeable to water Accurate Answer:- Descending limb loop of
Henle
Na/K exchange: Na+ reabsorbed, K+ excreted stimulated by Accurate
Answer:- Distal nephron: late DCT/CD
, Causes transient deafness Accurate Answer:- Furosemide
Only diuretic class that is ototoxic Accurate Answer:- Loop diuretics
(pg451)
Digoxin is potentiated with hypokalemia and ventricular dysrhythmias are
greatly increased. These diuretics promote K+ loss. Accurate Answer:-
Loop diuretics
Thiazide diuretics
Preferred drugs for mobilizing edema associated with mild to moderate 💕
failure Accurate Answer:- Thiazides
Diuretic Must be given parenterally. Only osmotic avail in US Accurate
Answer:- Mannitol
Diuretic Works on distal nephron to block Na+ and K+ Exchange Accurate
Answer:- Midamor
Hypokalemia is a special problem for patients taking ________ Accurate
Answer:- Digoxin
p.456
Aldactone Accurate Answer:- Blocks aldosterone in distal nephron
therefore there is LESS potassium excreted and more sodium
First line drugs for hypertension Accurate Answer:- Thiazides
Reduction of blood volume and reduction of arterial resistance (MOA)
Accurate Answer:- Thiazide diuretics
Principle adverse effect is hypokalemia Accurate Answer:- Thiazides
Produce much greater diuresis than thiazides Accurate Answer:- Loop
diuretics
Diuretics not used routinely for HTN Accurate Answer:- Loop diuretics
