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Bruce D. Clayton Chapter 1-48
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TABLE OF CONTENTS. jj jj
Unit 1: Applying Pharmacology to Nursing Practice
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Chapter 1: Drug Definitions, Standards, and Information
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Sources Chapter 2: Basic Principles of Drug Action and Drug
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Interactions Chapter 3: Drug Action Across the Life Span
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Chapter 4: The Nursing Process and Pharmacology
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Chapter 5: Patient Education to Promote Health
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Unit 2: Illustrated Atlas of Medication Administration
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Chapter 6: Principles of Medication Administration and Medication Safety
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Chapter 7: Percutaneous Administration
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Chapter 8: Enteral Administration
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Chapter 9: Parenteral Administration: Safe Preparation of Parenteral Medications
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Chapter 10: Parenteral Administration: Intradermal, Subcutaneous, and Intramuscular
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Routes
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Chapter 11: Parenteral Administration: Intravenous Route
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Unit 3: Drugs Affecting the Autonomic and Central Nervous Systems
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Chapter 12: Drugs Affecting the Autonomic Nervous System
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Chapter 13: Drugs Used for Sleep
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Chapter 14: Drugs Used for Neurodegenerative Disorders (NEW!)
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Chapter 15: Drugs Used for Anxiety Disorders
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Chapter 16: Drugs Used for Depressive and Bipolar Disorders
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Chapter 17: Drugs Used for Psychoses
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Chapter 18: Drugs Used for Seizure Disorders
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Chapter 19: Drugs Used for Pain Management
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Unit 4: Drugs Affecting the Cardiovascular
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System
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Chapter 20: Introduction to Cardiovascular Disease and Metabolic Syndrome
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Chapter 21: Drugs Used to Treat Dyslipidemias
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Chapter 22: Drugs Used to Treat Hypertension
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Chapter 23: Drugs Used to Treat Dysrhythmias
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Chapter 24: Drugs Used to Treat Angina Pectoris
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Chapter 25: Drugs Used to Treat Peripheral Vascular Disease
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Chapter 26: Drugs Used to Treat Thromboembolic
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Disorders Chapter 27: Drugs Used to Treat Heart Failure
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Chapter 28: Drugs Used for Diuresis
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Unit 5: Drugs Affecting the Respiratory System
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Chapter 29: Drugs Used to Treat Upper Respiratory
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Disease Chapter 30: Drugs Used to Treat Lower
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Respiratory Disease Unit 6: Drugs Affecting the Digestive
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System
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Chapter 31: Drugs Used to Treat Oral Disorders
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Chapter 32: Drugs Used to Treat Gastroesophageal Reflux and Peptic Ulcer Disease
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Chapter 33: Drugs Used to Treat Nausea and Vomiting
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Chapter 34: Drugs Used to Treat Constipation and Diarrhea
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Unit 7: Drugs That Affect the Endocrine System
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Chapter 35: Drugs Used to Treat Diabetes Mellitus
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Chapter 36: Drugs Used to Treat Thyroid Disease
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Chapter 37: Corticosteroids
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Chapter 38: Gonadal Hormones
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Unit 8: Drugs Affecting the Reproductive System
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Chapter 39: Drugs Used in Obstetrics
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Chapter 40: Drugs Used in Men‘s and Women‘s Health
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Unit 9: Drugs Affecting Other Body Systems
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Chapter 41: Drugs Used to Treat Disorders of the Urinary System
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Chapter 42: Drugs Used to Treat Glaucoma and Other Eye Disorders
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Chapter 43: Drugs Used to Treat Cancer
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Chapter 44: Drugs Used to Treat the Musculoskeletal System
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Chapter 45: Drugs Used to Treat Infection Unit 10: Drugs Affecting the General Health of the
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Body Chapter 46: Nutrition
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Chapter 47: Herbal and Dietary Supplemental Therapy
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Chapter 48: Substance Abuse
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,Chapter 01: Drug Definitions, Standards, and Information Sources
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Willihnganz: Clayton’s Basic Pharmacology for Nurses, 18th Edition
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MULTIPLE CHOICE jj
1. What is the name under which a drug is listed by the US Food and Drug
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jj Administration (FDA)? jj
a. Brand
b. Nonproprietary
c. Official
d. Trademark
ANS: C jj
The official name is the name under which a drug is listed by the FDA.
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The brand name, or trademark, is the name given to a drug by its
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manufacturer. The nonproprietary, or generic, name is provided by the
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United States Adopted Names Council.
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DIF: Cognitive Level: Knowledge REF: p. 2 OBJ: 1 jj jj j j jj j
NAT:NCLEXClient NeedsCategory: Safe, Effective Care Environment
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TOP:NursingProcess Step: Assessment
jj CON: Patient Education jj jj j j jj
2. Which source contains information specific to nutritional supplements?
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a. USP Dictionary of USAN & International Drug Names
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b. Natural Medicines Comprehensive Database jj jj jj
c. United States Pharmacopoeia/National Formulary (USP NF)
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d. Drug Interaction Facts jj jj
ANS: C jj
United States Pharmacopoeia/National Formulary contains information specific to nutritional
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supplements. USP Dictionary of USAN & International Drug Names is a compilation of drug
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names, pronunciation guide, and possible future FDA approved drugs; it does not include
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nutritional supplements. Natural Medicines Comprehensive Database contains evidence-based
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information on herbal medicines and herbal combination products; it does not include
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information specific to nutritional supplements. Drug Interaction Facts contains comprehensive
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information on drug interaction facts; it does not include nutritional supplements.
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DIF: Cognitive Level: Knowledge REF: p. 2 | p. 3 OBJ: 3 jj jj j j jj jj jj jj jj
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Assessment
jj CON: Nutrition | Patient jj jj j j jj j
Education
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3. What is the most comprehensive reference available to research a drug interaction?
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a. Drug Facts and Comparisons jj jj jj
b. Drug Interaction Facts jj jj
c. Handbook on Injectable Drugs jj jj jj
d. Martindale—The Complete Drug Reference jj jj jj
, ANS: B jj
First published in 1983, Drug Interaction Facts is the most comprehensive book available on
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drug interactions. In addition to monographs listing various aspects of drug interactions, this
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information is reviewed and updated by an internationally renowned group of physicians and
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pharmacists with clinical and scientific expertise.
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DIF: Cognitive Level: Comprehension REF: p. 4 OBJ: 3 jj jj j j jj j
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Assessment CON: Safety | Patient Education | Clinical Judgment jj jj j j jj jj jj jj jj jj
4. The physician has written an order for a drug with which the nurse is unfamiliar. Which section
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of the Physicians’ Desk Reference (PDR) is most helpful to get information about this drug?
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a. Manufacturer‘s section jj
b. Brand and Generic name section jj jj jj jj
c. Product category section jj jj
d. Product information section jj jj
ANS: B jj
A physician‘s order would include the brand and/or generic name of the drug. The alphabetic
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index in the PDR would make this section the most user-friendly. Based on a physician‘s order,
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manufacturer‘s information and classification information would not be known. The
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Manufacturer‘s section is a roster of manufacturers. The product category section lists products
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subdivided by therapeutic classes, such as analgesics, laxatives, oxytocics, and antibiotics. The
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product information section contains reprints of the package inserts for the major products of
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manufacturers.
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DIF: Cognitive Level: Comprehension REF: p. 4 OBJ: 3 jj jj j j jj j
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Planning CON: Safety | Patient Education | Clinical Judgment jj jj j j jj jj jj jj jj jj
5. Which online drug reference makes available to healthcare providers and the public a standard,
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comprehensive, up-to-date look up and downloadable resource about medicines?
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a. American Drug Index jj jj
b. American Hospital Formulary jj jj
c. DailyMed
d. Physicians’ Desk Reference (PDR) jj jj jj
ANS: C jj
DailyMed makes available to healthcare providers and the public a standard, comprehensive, up-
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to-date look up and downloadable resource about medicines. The American Drug Index is not
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appropriate for patient use. The American Hospital Formulary is not appropriate for patient
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use. The PDR is not appropriate for patient use.
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DIF: Cognitive Level: Knowledge REF: p. 3 | p. 5 jj jj j j jj jj jj jj OBJ: 4 j
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Implementation
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CON: Safety | Patient Education | Clinical Judgment
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6. Which legislation authorizes the FDA to determine the safety of a drug before its marketing?
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, a. Federal Food, Drug, and Cosmetic Act (1938)jj jj jj jj jj jj
b. Durham Humphrey Amendment (1952) jj jj jj
c. Controlled Substances Act (1970) jj jj jj
d. Kefauver Harris Drug Amendment (1962) jj jj jj jj
ANS: A jj
The Federal Food, Drug, and Cosmetic Act of 1938 authorized the FDA to determine the safety
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of all drugs before marketing. Later amendments and acts helped tighten FDA control and ensure
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drug safety. The Durham Humphrey Amendment defines the kinds of drugs that cannot be used
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safely without medical supervision and restricts their sale to prescription by a licensed
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practitioner. The Controlled Substances Act addresses only controlled substances and their
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categorization. The Kefauver Harris Drug Amendment ensures drug efficacy and greater drug
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safety. Drug manufacturers are required to prove to the FDA the effectiveness of their products
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before marketing them.
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DIF: Cognitive Level: Knowledge REF: p. 5 jj jj j j jj OBJ: 6 j
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Assessment
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CON: Safety | Patient Education | Evidence | Health Care Law
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7. Meperidine (Demerol) is a narcotic with a high potential for physical and psychological
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dependency. Under which classification does this drug fall?
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a. I
b. II
c. III
d. IV
ANS: B jj
Meperidine (Demerol) is a Schedule II drug; it has a high potential for abuse and may lead to
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severe psychological and physical dependence. Schedule I drugs have high potential for abuse
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and no recognized medical use. Schedule III drugs have some potential for abuse. Use may lead
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to low to moderate physical dependence or high psychological dependence. Schedule IV drugs
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have low potential for abuse. Use may lead to limited physical or psychological dependence.
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DIF: Cognitive Level: Comprehension REF: p. 5 OBJ: 2 jj jj j j jj jj
NAT:NCLEXClient NeedsCategory: Safe, Effective Care Environment
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TOP:NursingProcess Step: Assessment
jj CON: Patient Education | Addiction | jj jj j j jj jj jj jj
Pain
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8. What would the FDA do to expedite drug development and approval for an outbreak of
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smallpox, for which there is no known treatment?
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a. List smallpox as a health orphan disease.
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b. Omit the preclinical research phase.
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c. Extend the clinical research phase. jj jj jj jj
d. Fast track the investigational drug.
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ANS: D jj